Matteo Boretto, the first author on this study, commented that «we were very excited to see that we could not only robustly grow and amplify
endometrial tissue in a dish, but that the tiny structures were also able to reproduce normal responses of the endometrium to hormones: oestrogen makes the tissue
thicken, progesterone then induces maturation including folding (see picture), and subsequent removal of both hormones mimics the
cell shedding of the menstrual period.»
Also if there is supposed to be no period for several months doesn't that mean the
endometrial cells will remain highly vascular and
thickened like they would when a pregnancy takes place (i.e. how will this help the pain).