he continues to pose questions and do experiments that affect our ability to understand the human genome... and he continues to change the way
we think about the genome, how to navigate it, and what those changes mean in transcriptional regulation,» said Elaine A. Ostrander, NIH Distinguished Investigator and Chief of the Cancer Genetics & Comparative Genomics Branch at the National Human Genome Research Institute and one of those nominating Kruglyak for this honor.
Not exact matches
[1:20] How the kindness of a stranger changed Tony's life [3:35] Peter Diamandis talks
about the origins of X Prize [6:30] Technology helping the agricultural industry [7:00] Sequencing
genomes [8:55] Life - work integration [11:15] Finding your highest calling in life [12:00] Reframing what is «impossible» [14:00] Strategy vs. psychology [15:00] Changing your state [16:00] The science of achievement, the art of fulfillment [19:00] Living in a beautiful state [24:00]
Thinking 10x bigger [28:00] Surrounding yourself with a «nothing is impossible» community [29:00] The news pollutes your mind [31:00] Tony's natural gifts and core beliefs [33:30] Overcoming failure and criticism [37:45] Defining your environment [40:00] Life happens for you, not to you [42:00] Rituals and practices to up your game [46:30] Tony's priming process
I just
think it's really odd... when I was in school we were talking
about all the wonders that will come from mapping the human
genome... but I don't recall the term microbiome being mentioned a single time..
«I
think what's interesting
about combining whole
genome analysis and histopathology is that we can study the tumor at multiple levels,» said co-author Rakopoulos.
Fussenegger
thinks that
genome editing will be the favoured approach for therapies, but that writing
genomes from scratch will appeal to scientists interested in fundamental questions
about how
genomes evolve, for instance.
But Knome founder George Church's
genome has
about three times as much Neandertal, which we
thought was funny.
«It took full
genome sequences and a lot of good sense
about how to cull the data, and I
think that their conclusions are really robust.»
Think of a 166 million - piece jigsaw puzzle, given that the size of the B. braunii
genome is estimated to be
about 166 million bases, he said.
She concedes that there are risks of making predictions like these, but adds: «I believe that people should have access to information
about themselves, and I
think it's laudable that 23andMe has helped pave the way for people to better understand their
genomes.»
This catalog «will change the way people
think about and actually use the human
genome, says John A. Stamatoyannopoulos, an ENCODE researcher at the University of Washington, Seattle.
All together, the researchers found
about 37,000 mutations occurring in 10,000 clusters in the chimp and human
genomes that they
think were caused by these proteins, they report today in
Genome Research.
«I don't
think there is necessarily one area of the
genome that's going to tell you everything
about performance,» Doodnauth says.
So we have this huge
genome, our DNA, if you
thought of it as letters, you have
about three and one half billion letters long.
«There does seem to be an upper bound of what we can learn
about common diseases with multiple causes,» says Kraft, who
thinks the paper illustrates why «we're not going to have a huge impact» on the average person with
genome sequencing.
Much of we
thought we knew
about the
genome is proving too simplistic, show The Deeper Genome and The Developing G
genome is proving too simplistic, show The Deeper
Genome and The Developing G
Genome and The Developing
GenomeGenome.
We provide initial insights into two critical issues: what clinical value can be extracted from different commercial and academic cancer genomic platforms, and how to
think about scaling access to that value,» noted the study's Principal Investigator, Robert Darnell, MD, PhD, Robert and Harriet Heilbrunn Professor and Senior Attending Physician at The Rockefeller University and Founding Director of the New York
Genome Center.
Think about it: on a HiSeq X Ten instrument, we can sequence a complete human
genome in less than a week, at a cost that's 0.00001 % of what it took to fund the Human Genome Pr
genome in less than a week, at a cost that's 0.00001 % of what it took to fund the Human
Genome Pr
Genome Project.
I was working in a community of people who were all
thinking about looking at genetic variations, of how you might look at them and how you might understand them, and so reading lots of papers from other folks who were doing great work in that area I just looked at ways that you could basically go across the human
genome and look at every variation, everything that's variable between human populations.
Though the HGP achieved its proposed goals, some
think discussion
about the
genome's potentials in the future was too ambitious.
The number of lethal loci in the Drosophila
genome is
thought to be
about 5000 (Nusslein - Volhard, 1994; Lewin, 1994), but new data allow us to refine this figure downwards.
Along with changing how we
think about genes, the Human
Genome Project spawned lots of other projects.
The next time you carve a pumpkin, take a moment to
think about the curious evolutionary path it took to get here, and how breeders, now armed with the
genome sequence, will be better able to improve the pumpkin to help feed millions around the world.
Having your
genome sequenced is a personal choice that may change the way you
think about yourself and your family.
As cancer
genome sequencing ramps up here and pretty much everywhere around the world, I got to
thinking about strategies for identifying somatic changes, with confidence, from massively parallel sequencing data.
Putting aside any questions
about how useful this information is right now and how it is marketed, do you
think companies should be able to offer a service where consumers send in a spit or blood sample and a few hundred dollars and get their
genome sequenced in return?
I
think that few people appreciate the scale of the 1,000
Genomes Project and just how much information it's already yielding
about human genetic variation.
Unlike Kurzweil, I don't view the brain or
genomes as computer codes but I will read more
about his work and ideas as he makes me
think about some of my unconscious (pun intended) assumptions.
«But with the completion of the human
genome sequence and the availability of the kinome, one can begin to
think about how to do this in a much wider and unbiased sense.»
The information gained from
genome sequencing can not be «unlearned»: it may change the way you
think about your health and the health of your family, who you are, and how you see yourself in the world.
Kucherlapati: Without
thinking about modifying the human
genome line, would this technology have the ability to affect the health of humans by modifying the stem cells?
It might be useful to
think about the Human
Genome Project, where similar issues came up about a decade ago, and there was clear discussion about this, and in the public genome sequencing laboratories, a real commitment, dedication to getting that data out into the public as soon as pos
Genome Project, where similar issues came up
about a decade ago, and there was clear discussion
about this, and in the public
genome sequencing laboratories, a real commitment, dedication to getting that data out into the public as soon as pos
genome sequencing laboratories, a real commitment, dedication to getting that data out into the public as soon as possible.