They talk about the most important mechanism by which Mercury causes toxicity appears to be Mitochondrial damage via the depletion of Glutathione, coupled with binding to
thiol groups, which generate free radicals.
Enzymes use beneficial metals for their activity and hold those metals in place with
thiol groups.
CDDO - Me reacted with
thiol groups as determined by detection of specific adducts by LC - MS (Tables S1 and S2 and Figure S3 in Data S2).
Not exact matches
The researchers modified the HA molecules by attaching adamantane and cyclodextrin
groups to allow the gels to flow through catheters, and they added
thiol and methacrylate
groups to enable post-injection cross-linking to stiffen the hydrogel.
The sulfhydryl (often referred to as
thiol)
group on the cysteine acts almost like a lint roller for the toxic free radicals produced during oxidative stress.