Sentences with phrase «threose nucleic»

Says Roberts: «He quickly figured out that if Illumina was successful, it would need more than the world's supply of oligonucleotides» — the short snippets of nucleic acid that are designed to pair up with specific genetic sequences, and which are critical for DNA or RNA analysis.

One way to shut down the communication link is through a snippet of RNA called «antisense» — which binds to the messenger RNA (a «sense» - making strip of nucleic acids) that is transcribed by a given stretch of DNA.

What happens when we replace the four building blocks of DNA with six — that is to say, the four nucleic acids that have stood through billions of years of evolution plus two new versions that came out of a San Diego lab last year?

This blockchain manager would «compute a cryptographic hash» of a given «nucleic acid sequence» and «use» it as PoW before transmitting the attendant «new block... to the other nodes in [the] blockchain system.»

According to one of his analogies: just as the sequence of letters on a page is extraneous to the chemistry of ink and paper, so the sequence of nucleic acids in the DNA molecule (which, when translated, determines the shape of an organism and its specific characteristics) is extraneous to the chemical forces operative in the genetic process.

Were there not a certain invariance about the way in which carbon atoms bond with others under identical conditions, or about the manner in which protein synthesis is charted and activated by nucleic acids, life would be impossible altogether.

Still is it not possible that the specific sequence of base - pairs in a DNA molecule is extraneous to the chemistry which bonds the nucleic acids to one another?

The «secret» of life, growth and heredity seems to lie in the movement and combination of nucleic and amino acids.

The letters of this code are nucleic acids (A, C, T and G) arranged sequentially in triadic formations.

So we must ask whether chemistry (or any physical science) can specify the overall sequence of nucleic acids that determines the kinds and shapes of organisms existing in the biosphere.

I have been concerned to show, elsewhere, 6 that the same set of epistemological limitations encountered at the transition to the life sciences and cognitive psychology are evident at the level of chemical theory and its dependence upon the quantum theory relevant to nucleic and electronic constituents.

Out of the Gordon Conference on nucleic acids in the summer of 1973 came an open letter to Science; the establishment (in October 1974) by the National Institutes of Health of the Recombinant DNA Molecule Program Advisory Committee; and in February 1975 the now - famous international conference at the Asilomar Conference Center in California, where a reluctant decision was made by scientists to declare a temporary moratorium on certain kinds of DNA research.

A preference for atomicity (explanation in terms of amino and nucleic acids) prescribes the method for molecular biology; and a persistent materialism hovers over the essentially anti- mechanistic physics of this century.

This task involves analyzing no less than 3 billion pairs of nucleic acids.

it is there for very easy to expect that 3.5 - 4 billion years ago there were pools of water full of self replicating nucleic acids.

if you disolve a mixture of carbon dioxide, sulther dioxide and ammonia all of which occur naturally in water and then run a high voltahe electric current through it (i.e lightning) amino acids and nucleic acids will spontaneously form and breakdown as the chemicals react.

The shortest chain of nucleic acids capable of replicating itself consists of only 6 molecules.

Nucleotides and amino acids are substances which, there is reason to believe, could have been formed, and polymerized into nucleic acid and protein respectively, under certain conditions on a lifeless earth.

Even if the a priori probabilities of its happening the first time are virtually zero, Jacques Monod holds that it still might happen nonetheless.1 Furthermore, it has been demonstrated that the amino and nucleic acids which life requires could already have been made plentifully available by rather «impersonal» natural processes.

The apparent gap between nonliving and living has now been bridged by nucleic acids, a class of polymeric organic molecules composed of a succession of small units (nucleotides) of four sorts, the order of which determines an indefinitely large number of different specificities.

For example, after the macromolecules of amino acids or nucleic acids have become sufficiently abundant, the possibility of living cells becomes a relevant new form of ordered novelty in the world's advance.

They are the principal component, other than water, of all living forms, but the nucleic acids alone have the remarkable property of being capable of duplicating their patterns, whatever they may be, from small molecules in their medium.

The probablility of all the cellular machinery (enzymes, ion channels, RNA polymerase, anabolic and catabolic pathways, etc) just assembling out of randomn peptides and nucleic acids is infinitely small.

I have followed Polanyi's contention that there are organizational principles operative in the universe which formatively influence the specific sequences of nucleic acids in DNA, and with Sheldrake I have postulated the existence of morphogenetic fields which canalize the processes of growth and development in organisms.

Healthy fats like alpha - linolenic acid, oleic acid, a balanced supply of Omega - 3 and Omega - 6 fatty acids; Nucleic acids for building DNA and RNA;

The four major classifications of biological molecules are proteins, carbohydrates, lipids (fats), and nucleic acids (but we won't be dealing with these today).

They also contain nucleic acids.

«It's difficult to make contrived samples behave like actual cell - free nucleic acids, so that's been quite a challenge,» says Kelli Bramlett, director of R&D in clinical sequencing and oncology at Thermo Fisher Scientific in Waltham, Massachusetts.

«It's a type of molecule called an antisense oligonucleotide, or ASO, that essentially is synthetic string of nucleic acid that binds a specific sequence in the gene.»

A year earlier James Watson and Francis Crick had proposed their double - helix model of DNA, the nucleic acid that conveys genetic information from generation to generation in all organisms except certain viruses.

Of the three methods, nucleic acid — based liquid biopsies appear to be taking an early lead.

He studies DNA and RNA quadruplexes, nucleic acid structures that were first visualized via confocal microscopy in fixed, dead cells.

The new methods allowed them to catch proteins in the act of binding to RNA, and also identify what part of the protein was in contact with the nucleic acid.

Using nucleic acids can mitigate or eliminate this problem, especially with the high degrees of multiplexing seen in the platform of Olink Proteomics, headquartered in Uppsala, Sweden.

Even after initial purification of the sample, liquid biopsies typically contain much more nucleic acid from healthy cells than from tumors.

My colleagues and I first undertook to synthesize nucleic acids outside the living cell, with the help of cellular enzymes, in 1954.

In the study, which was published in the journal Nucleic Acids Research, the biologists utilised so - called riboswitches, also called RNA switches, and RNA thermometers.

The field segregates into three major strategies: detecting free nucleic acids, isolating intact circulating tumor cells, and identifying extracellular vesicles from tumors.

Nucleic acids are also helping scientists to detect biomarkers, such as Abcam's Fireplex (formerly Firefly) particle technology, which profiles biomarker microRNAs (miRNAs) directly from biofluid samples, without RNA purification.

The spherical structure of the SNAs is the ideal architecture for delivering nucleic acids into cells for gene regulation, Mirkin said.

They combined spherical nucleic acids (SNAs, which are nanoscale globular forms of RNA) with a common commercial moisturizer to create a way to topically knock down a gene known to interfere with wound healing.

The exterior of the nanoparticle is coated with nucleic acids that act as targeting agents, drawing the delivery system to the retina and facilitating uptake by RPE cells.

That is, they depend on the host cell for the raw materials and energy necessary for nucleic acid synthesis, protein synthesis, processing and transport, and all other biochemical activities that allow the virus to multiply and spread.

They naturally enter cells by engaging scavenger receptors that are not recognized by linear nucleic acids.

«It is the only known nucleic acid platform for treating such ailments and constitutes a new pipeline of therapeutics to address a broad swath of debilitating health conditions.»

So that has made us look again at the chemistry of replication and start to explore a wider range of nucleic acids.

The tests use the so - called polymerase chain reaction (PCR), a conventional method for detecting nucleic acid.

To start, she used a cotton swab to get a sample of cells from her cheek, boiled them in a test tube in her kitchen to free the DNA, then added primers, nucleic acids that mark the part of the sequence.

Over the past decade, healthcare providers have been able to expand screening programs for chlamydia thanks to the development of a highly sensitive method known as nucleic acid amplification testing (NAAT).

Together with his principal investigator (PI), he had realized the commercial potential of modifying nanoparticles with nucleic acids to create targeted, personalized medicines for a myriad of diseases.