Sentences with phrase «through autocrine»
Consequently, we conclude that the classical endotheliocentric view of Tie2 signalling with Ang1 acting in a paracrine manner and Ang2 through an autocrine loop needs to be revised in favour of a bi-directional reciprocal model in which the EC signalling is complemented reciprocally by an autocrine Ang1 / Tie2 loop in pericytes and paracrine acting Ang2 (Fig. 7).
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Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin - like growth factors.
Autocrine motility factor / phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release.
Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.