Sentences with phrase «through changes in the regulation»

Many, if not all, oncogenes and tumor suppressor genes induce metabolic reprogramming in cancer cells through changes in the regulation of enzymes and transporters.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Established to help promote the interests of European businesses operating within ASEAN and to advocate for changes in trade and investment policies and regulations, the EU - ABC raises the profile of European businesses in the region through formal events and high - profile dialogues.

So much has changed over the past few years in the credit card industry, what with new regulations, the disappearance of easy credit, the reduction of credit card offers and advertisements through the mail, and not to mention, the expiration of lifetime balance transfer programs (and awesome card terms).

In short, anyone who appreciates the rapid change in historical circumstances and does not flee from this into a ghetto; anyone who knows that there is and always has been a mutable, human law of the Church, and that this kind of change has always been practised; anyone, moreover, who reflects that the Church not only has the right but the duty of shaping its canon law in accordance with changes in the times, will not be surprised at the change in many legal regulations which he is living through at the present time, but will recognize and accept this as a sign of the vitality of the Church and its pastoral carIn short, anyone who appreciates the rapid change in historical circumstances and does not flee from this into a ghetto; anyone who knows that there is and always has been a mutable, human law of the Church, and that this kind of change has always been practised; anyone, moreover, who reflects that the Church not only has the right but the duty of shaping its canon law in accordance with changes in the times, will not be surprised at the change in many legal regulations which he is living through at the present time, but will recognize and accept this as a sign of the vitality of the Church and its pastoral carin historical circumstances and does not flee from this into a ghetto; anyone who knows that there is and always has been a mutable, human law of the Church, and that this kind of change has always been practised; anyone, moreover, who reflects that the Church not only has the right but the duty of shaping its canon law in accordance with changes in the times, will not be surprised at the change in many legal regulations which he is living through at the present time, but will recognize and accept this as a sign of the vitality of the Church and its pastoral carin accordance with changes in the times, will not be surprised at the change in many legal regulations which he is living through at the present time, but will recognize and accept this as a sign of the vitality of the Church and its pastoral carin the times, will not be surprised at the change in many legal regulations which he is living through at the present time, but will recognize and accept this as a sign of the vitality of the Church and its pastoral carin many legal regulations which he is living through at the present time, but will recognize and accept this as a sign of the vitality of the Church and its pastoral care.

The updated regulations should cut down on the number of variation requests that come through the village, address a number of changes in the sign industry and be more user and business friendly, said Staci Hulseberg, Glen Ellyn's director of planning and...

The updated regulations should cut down on the number of variation requests that come through the village, address a number of changes in the sign industry and be more user and business friendly, said Staci Hulseberg, Glen Ellyn's director of planning and development.

«The pace of change in the development of technology in this field is really rapid,» he said, adding that the new Automated & Electric Vehicles Bill going through Parliament will look to solve some of the challenges around insurance and regulation.

Rep. Ryan Costello of Pennsylvania said he supports a ban on bump stocks, whether it's done through legislation or a change in federal regulations.

However, scientists have recently found that gene regulation can also happen in an ongoing fashion through epigenetic processes, with the potential to change behavior throughout a lifetime.

The major goals of this project are to determine the combined influences of light and gravity on plant development through the identification of changes in the mechanisms and regulation of essential cellular functions.

Their paper Coral resilience to ocean acidification and global warming through pH up - regulation by Malcolm McCulloch, Jim Falter, Julie Trotter, and Paolo Montagna, appears in the latest issue of the journal Nature Climate Change.

Kazuko Nishikura, Ph.D., discovered a mechanism of RNA regulation through which cells can make discrete changes in the sequence of nucleotides — the «letters» in the RNA code, ultimately affecting the protein product.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

You'll learn practical ways to apply this science immediately through the MELT Hand and Foot Treatments — and how these simple self - treatments can improve your body's ability to restore balance and support cellular repair and regulation, which can create remarkable, lasting changes in just a few minutes a day.

In «A Strong Start on Advancing Reform,» Burke argues that the administration has already made some positive strides in improving K — 12 and higher education through policy changes, rescissions of Obama - era regulations, and rhetorical support of school choicIn «A Strong Start on Advancing Reform,» Burke argues that the administration has already made some positive strides in improving K — 12 and higher education through policy changes, rescissions of Obama - era regulations, and rhetorical support of school choicin improving K — 12 and higher education through policy changes, rescissions of Obama - era regulations, and rhetorical support of school choice.

Broadly, the administration shaped K — 12 and higher education in three primary ways in 2017: through policy changes in conjunction with Congress; through considerable rescissions of Obama - era regulations; and through rhetorical markers on a variety of issues affecting education.

The proper mechanism for improving compensation and work conditions in the public sector is through changes in law and regulation.

It may have taken longer than many would like to integrate the military, expand the roles of women in the armed forces, and end «don't ask, don't tell,» but we were able to achieve all of those through an open, public process of changing laws and regulations.

Much will change in practice and policy as the Every Student Succeeds Act (ESSA) replaces the law, regulations, and guidance established through NCLB; but two elements of the new legislation stand out: the shift away from federal mandates toward greater state and local authority, and the emphasis on evidence - based school improvement practices.

Over the last several years, Delaware passed and implemented significant authorizer quality and school accountability reforms through law, regulation, and changes in practices.

However, Porsche announced in August 2005 that it would not continue production of the Carrera GT through to 2006, citing discontinuation was due to changing airbag regulations in the United States.

Changing regulations in Canada's mortgage market Since 2008, the federal government has made several changes to the rules for mortgages insured through the Canada Mortgage and Housing Corporation (CMHC) and other private sector mortgage insurance providers.

I think the world is too tolerant of lax morality — but I also think the most effective way to create change is through spreading knowledge, pushing for consumer action and calling for changes in laws and regulations.

Through a combination of insulin and dietary changes, initial regulation of your diabetic dog will help to control their disease, and you should see positive changes in their energy, body condition and other symptoms within a few weeks.

Under the outdated regulations, this change in selling practices meant that many commercial breeders no longer were required to be licensed by USDA as pet dealers, even if they were large scale pet breeders selling their puppies to consumers through remote methods.

It is important to understand that the rules and regulations for import of privately owned pets is determined by the country you are traveling into — and any country you travel through in order to get to your destination — and that country has the right to change their regulations at any time.

Some substantive changes are introduced in this notice, but many clarifications through rewording have been made to existing regulations.

We have used the Model for the Assessment of Greenhouse - gas Induced Climate Change (MAGICC)-- a simple climate model emulator that was, in part, developed through support of the EPA — to examine the climate impact of proposed regulations.

In addition to causing losses to Riau residents through negligence, the plaintiffs are also accusing defendants of violating Indonesian laws and regulations related to forest management and climate change mitigation.

We interviewed entrepreneurs in Kenya, India, Bangladesh and Indonesia — all countries where the energy access challenge is acute or has unique features — and asked them what changes in policy and regulation would help expand access to energy through distributed renewable sources.

Civil society, governments and business communities must accept that if we do not change the way we live on this planet and do something to reduce drastically the carbon footprint and increase dramatically access to renewable energy now through tougher regulations and an overhaul of the fossil fuel industry (stop subsidizing the polluters and begin funding the human solutions to climate change), the planet will continue to change in devastating ways.

In the 21st century, the eugenics movement has changed its stripes once again, manifesting itself through the global carbon tax agenda and the notion that having too many children or enjoying a reasonably high standard of living is destroying the planet through global warming, creating the pretext for further regulation and control over every facet of our lives.

AP debunks Obama on climate claims: THE FACTS: «Obama failed to get a global warming bill through Congress when both Houses were controlled by Democrats in 2010» — AP: «With Republicans in control of the House, the chances of a bill to limit the gases blamed for global warming and to create a market for businesses to trade pollution credits are close to zero... And while there are still other ways to address climate change without Congress, it's questionable regulation alone can achieve the reductions needed to start curbing global warming»

Just like banking regulations after the Great Recession; just like tobacco regulations after decades of the industry lying; just like decades of the asbestos industry lying; just like the soda industry continues to lie about fructose today; just like the airline industry didn't change policies on protecting the cabin until after 9/11 (the first US hijacking was in the 1960's); just like the gun industry through the lobbyists like the NRA continues to drag their feet... The force for change will have to be from the BOTTOM UP.

A globally coordinated umbrella of organisations and parties that drive systemic changes in existing political economic norms and that drives social change through positive constructive evidence based humane laws and regulations that then drives sustainable generational changes in economic norms, climate change solutions investments and technological change for the good of all people and not the few.

The expected outputs range from integrating climate change risks into development planning and coastal zoning regulation to diversifying livelihoods to finding more secure sources of water in communities where saline intrusion is a problem (Community Based Adaptation to Climate Change through Coastal Afforestachange risks into development planning and coastal zoning regulation to diversifying livelihoods to finding more secure sources of water in communities where saline intrusion is a problem (Community Based Adaptation to Climate Change through Coastal AfforestaChange through Coastal Afforestation).

The regulation also cites ACR's voluntary offset methodology for Emissions Reductions in Rice Management Systems as an approved Early Action Quantification Methodology, providing an important on - ramp for rice producers in California and the Mid-South to get credit for their pioneering initiatives to reduce methane emissions through practice changes in water management, such as reduced flooding and altered drainage timing.

The Nova Scotia Barristers» Society released a detailed report last October entitled «Transforming Regulation and Governance in the Public Interest» — a thorough look at all the seeds of change from technology through unbundling, new law firm structures, globalization, the greying bar, growth of in - house counsel, and more.

I have looked in all the publications the Ontario government has released about the changes, reviewed every ESA regulation, annoyed all my colleagues asking questions about this, had an articling student call the Ministry of Labour, and ctrl + f'd through months of transcripts of legislature debates and can not find a single mention of a «recognition».

At least when they were in the regulations we could trace the changes through the indexing.

The regulations under Bill C - 25 are still in draft form, and still have to go through a public consultation process before they are finalized, mostly in the next 18 to 24 months, and there may be changes made, she adds.

Whether you are an investment company seeking help responding to the ever - changing regulations, a financial institution recently contacted by the SEC or FINRA, a public or private company interested in growth through acquisitions, or an organization concerned about protecting its intellectual property or contract rights, Stradley Ronon lawyers bring both legal ability and business acumen to bear in addressing the challenges you face.

However, all lawyers and Law Societies in Canada would be wise to heed the warnings in the last paragraph of that report: «where benefits to the consumer can be attained with proper regulation to ensure that professional values are not lost, the Law Society must develop proper regulation to allow for changes to the profession through which improved access to legal services can be attained.»

Major changes in immigration policy have historically been achieved through legislation and regulations, which would normally involve public consultation, task forces, discussion papers, committee hearings, and parliamentary debate, as well as consultation of regulations before approval by Cabinet.

The commenter reasoned that since the ERISA definitions may change over time through statutory amendment, Department of Labor regulations or judicial interpretation, it would not be clear what point in time is to be considered current.

Rajesh Sud, CEO and MD, Max New York Life says, «Life insurance industry is currently going through the process of adapting their business model to suit the new environment created mainly due to change in regulations.»

Furthermore, consistent with similar exclusions under the marketwide regulations for Exchange - specific special enrollment periods, we are also clarifying that the triggering event described at § 155.420 (d)(6) will not create a special enrollment period to enroll outside the Exchange to the extent it concerns an individual who becomes newly eligible for APTC or who has a change in eligibility for cost - sharing reductions other than a total elimination of eligibility, since financial assistance is only available for coverage purchased through an Exchange.

Rajesh Sud, CEO & MD, Max New York Life Insurance says, «The life insurance industry is currently going through the process of adapting their business model to suit the new environment created mainly due to change in regulations.

Comprised of more than 17,000 member companies, COSE has a long history of fighting for the rights of all small business owners, whether it's through group purchasing programs for health care, workers» compensation, or energy, advocating for specific changes in legislation or regulation to benefit small business, or providing a forum and resource for small businesses to connect with and learn from each other.