Sentences with phrase «through deacetylation»

Not exact matches

Through synthetic viability screening, we discovered that histone H4 K16 deacetylation drives the sensitivity of yeast cells to camptothecin and that inactivation of this pathway by mutating H4 K16 or the genes SIR1 - 4 suppresses much of the hypersensitivity of tof1 ∆ strains towards this agent.