Sentences with phrase «through epigenetic modifications»

What's come out in recent years are findings that experiences in an adult organism can, through epigenetic modifications in the sperm and egg cells, be passed onto subsequent generations, leading to some provocative notions.

Nestler: The ability of this chronic social stress to produce maladaptive changes in brain and behavior are mediated through epigenetic modifications of gene expression in particular emotional centers of the brain.

What we found is that the ability of this chronic social stress to produce maladaptive changes in brain and behavior — loss of pleasure, inability to sleep normally and so on — are mediated through epigenetic modifications of gene expression, in particular, emotional centers of the brain.

Researchers at the University of Zurich have now identified a mechanism how cells pass on the regulation of genetic information through epigenetic modifications.

Schrock: I'm sure that's been tried, but one of the new things they found is this specific tie between the circadian rhythm in our bodies and drug addiction and they found that it is actually through an epigenetic modification of the circadian rhythm; so our circadian rhythms are reset by these drugs; we actually crave them at certain times of day and that is contributing to the necessity to, you know, relapse and go back on drugs or to get that craving, you know, at a certain point.

Finally, animal research focusing on brain - structural aspects related to early care and the new, conceptually important direction of studying environmental programming of early development through epigenetic modification of gene functioning is examined in brief.

Not exact matches

He explains that cells could potentially lower their 19S subunit levels through a wide variety of epigenetic mechanisms, including microRNAs, transcription regulation, and histone modifications.

Indeed epigenetic DNA modifications are inherited through cellular replication and errors in their positioning might be lethal for the cells and the pathways that are related to them.

It is well known that HDAC inhibitors are potent anticancer drugs in hematopoietic malignancies, including lymphoma.19 — 21 The aim of using HDAC inhibitors is to restore normal histone modification patterns through inhibition of various components of the epigenetic machinery.22, 23 In B - cell lymphoma, HDAC inhibitors can rescue deficits in histone acetylation induced by EP300 / CREBBP mutations, 24 rendering tumor cells more sensitive to suberoylanilide hydroxamic acid.25 This can explain why chidamide also has favorable efficacy on PTCL - NOS patients bearing EP300 / CREBBP mutations.

«Many of the carcinogens present in mainstream smoke are known to exert their effects through a genotoxic mode of action, which is based on their ability to induce DNA damage and mutations, although an epigenetic mode of action, e.g., through aberrant DNA methylation and histone modifications, is also beginning to emerge for a few of these carcinogenic compounds.»