Not exact matches
Derived mostly from human embryonic kidney 293T (HEK293T) and HeLa cell lines, EdiGene
Knockout (KO) Cell Lysates have been optimized through the use of genome editing technology and validated at the genomic level through PCR and Sanger - sequencing techniques to ensure the accuracy and knockout of the targ
Knockout (KO) Cell Lysates have been optimized
through the use of genome editing technology and validated at the genomic level
through PCR and Sanger - sequencing techniques to ensure the accuracy and
knockout of the targ
knockout of the target
gene.
The first group was mice with targeted deletion of the interleukin 10 (IL10)
gene, known as interleukin 10
knockout (IL10 - / --RRB- mice, which develop colitis
through T helper immune cells.
Researchers typically use viruses for two types of studies --(1) knock - in; introducing a protein - coding
gene into cells to study its function, or (2)
knockout / knockdown; studying
gene function
through deletion (potentially using CRISPR lentivirus
knockout libraries) or reduction of
gene expression, respectively.
TRPV1:
Gene knockout of the pain receptor TRPV1 is one of a number of methods of slowing aging and extending life in mice that appears to work
through altered insulin signaling.
To address this challenge, the International Mouse Phenotyping Consortium is creating a genome - and phenome - wide catalog of
gene function by characterizing new
knockout - mouse strains across diverse biological systems
through a broad set of standardized phenotyping tests.
To assist drug development
through the identification of essential
genes and pathways, we have measured competitive growth rates in mice of 2,578 barcoded Plasmodium berghei
knockout mutants, representing > 50 % of the genome, and created a phenotype database.