Sentences with phrase «through gene transcription»

[9] This is achieved through gene transcription which is followed by the processes of translation and assembly of proteins into the contractile architecture.

Not exact matches

In Class II engagement, Sox9 binds to multiple active enhancer elements through sub-optimal, low - affinity Sox dimeric motifs (DNA sequences), resulting in a high level of transcription of cartilage - related genes.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.

«We concluded that RAC1 regulates lung branching morphogenesis, in part through the so - called canonical Wnt signaling pathway, which leads to the regulation of the transcription of many genes,» said principal investigator Denise Al Alam, PhD, of the Department of Surgery and the Developmental Biology and Regenerative Medicine Program at The Saban Research Institute.

Active genes produce molecular messages called RNA through a process called transcription.

Through genetic mapping, her lab has found that many of the genes in Arabidopsis are also conserved in grasses; however, that does not guarantee that transcription factors in the plant would work the same way.

The new consortium proposes to characterize and tag the 1486 known transcription factors — proteins that switch genes on and off — in the mouse genome, as well as an estimated 600 coregulators that chip in to control cellular and biological functions through networks called regulons.

Found that proteins bound to the cytoplasmic portion of one subtype of glutamate receptor, the N - methyl - D - aspartate receptor, play a critical role coupling local calcium influx through the channel to elicit adaptive gene transcription in neurons.

Further, we identified a role for ABL kinases in promoting the expression of multiple pro — bone metastasis genes such as AXL (which encodes a receptor tyrosine kinase), IL6 (which encodes interleukin - 6), MMP1 (which encodes matrix metalloproteinase 1), and TNC (which encodes tenascin - C) through TAZ - and signal transducer and activator of transcription 5 (STAT5)-- mediated signaling.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

We have recently shown that transcription proceeds rapidly and efficiently through these genes and that splicing of the very long introns found in such genes is also efficient.

First, we will use our unique DNA - and chromatin - templated in vitro transcription systems to investigate the direct role of p53 serine18 phosphorylation in sestrin gene activation through modulation of p53 - coactivator interactions.

Specifically, we have shown that the condensin subunit Cnd2 binds directly to the most important general transcription factor, the TATA box - binding protein TBP, and that TBP recruits condensin molecules onto RNA polymerase III - transcribed genes and highly active Pol II - transcribed genes (many ribosomal protein genes) through the Cnd2 - TBP interaction (Figure A).

FoxP2 is a transcription factor, thus the mechanism by which it exerts its function (s) is through control of downstream genes.

Modulation of Host Cell Gene Expression through Activation of STAT Transcription Factors by Pasteurella multocida Toxin

LncRNAs have been shown to regulate gene expression by modifying chromatin, enhancing transcription, and promoting messenger RNA (mRNA) degradation as well as through other methods that have yet to be elucidated.

Leishmania lacks classical regulation of transcription at initiation through promoters, so aneuploidy could represent a major adaptive strategy of this parasite to modulate gene dosage in response to stressful environments.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

Through this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment diThrough this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dithrough direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dictates.

Transcription factor and EST clusters can be accessed through the «Specific Gene Classes» window of the FunGenES Database.

In addition, the DHA and EPA found in fish oil have a powerful ability to enhance the metabolism and increase fat burning by positively altering the gene functioning through various mechanisms which include changing the makeup of cell membranes, altering the transcription of genes and influencing the levels of calcium within the cells.

Through processes called transcription and epigenetics, those critical genes switch on to guide the process.