Sentences with phrase «through multiple cell»

The transmission of different states of gene expression through multiple cell divisions and across generations has been termed «epigenetic,» since the underlying DNA sequence is identical in both states.

«That shows that the pattern of marks that was inherited is being transmitted through multiple cell divisions.»

Not exact matches

Multiple cells can be linked together, or can «listen» to other cells through a concept called hash - linking, in which specific hash - tagged terms cause other cells to be included on a particular communiqué.

If fibrin excess can trigger unwanted inflammation in nerve tissue and increase breakdown of the myelin wrapping the nerve cells (a process that is usually referred to as demyelination), health problems like multiple sclerosis (in which there is breakdown of the myelin nerve sheath) may be lessened through reduction of excess fibrinogen and / or fibrin.

Or maybe passing through multiple liver cells somehow activates the parasite, preparing it for the real thing.

This finding comes as a surprise, considering that the average migration speed of the larger cell population does not change through multiple cycles.

«In modern biology mitochondria are considered to be much more than the powerhouse of the cell; they integrate multiple intracellular signals to regulate progression through the cell cycle and into apoptosis.

Syndax Pharmaceuticals, Inc. («Syndax,» the «Company» or «we»)(Nasdaq: SNDX), a clinical stage biopharmaceutical company developing entinostat and SNDX - 6352 in multiple cancer indications, in collaboration with The Wistar Institute and Indiana University Melvin and Bren Simon Cancer Center, today announced the publication of a preclinical report demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

Cancer cells resemble stem cells not because they can turn into other cell types, but because in developmental terms, they seem to go in the opposite direction: they begin to run through multiple layers of stop signs and barricades and just keep on multiplying.

This enhances the immune response through multiple mechanisms: by attaching to the myeloma cells, it marks them for destruction, and by attaching to the NK cells, it primes the immune cells to search for and attack the myeloma cells.

Evidence of infection and replication of the two principal viral groups that infect humans was demonstrated for multiple passages of viruses through cell culture (Figure 1).

On the one hand, it regulates progression from premalignancy to malignancy, most likely by preventing oxidative stress - induced death of HCC - initiating cells, thereby allowing such cells to accumulate multiple oncogenic mutations, while promoting their growth through mTORC1.

Willet, Mills, and their colleagues believe the discovery that cells in different organs go through the same process to become proliferative could lead to new potential targets for cancer treatment because the factors that initiate tumours could be the same in multiple organs.

Tumours develop from normal human cells through a complex process with multiple stages.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Multiple studies have shown that fascin, through its role in formation of cellular protrusions such as filopodia and invadopodia, enhances cancer cell migration and invasion in vitro.

Tanioka and his colleagues analyzed multiple biologic features of cancer cells from 213 patients treated for HER2 - positive breast cancer through a National Cancer Institute cooperative group clinical trial, CALGB 40601.

A malevolent artificial lifeform, Cell was born through experiments made by Doctor Gero's computer from the cells of multiple warriors, combined with the generic information of Goku, Vegeta, Piccolo and other Dragon Ball stalwarts.

That said however, if you have been diagnosed and been able to demonstrate that through stem cell therapy that you no longer suffer from myelofibrosis, we would be happy to «submit» your life insurance application to multiple insurance companies to see if their underwriting guidelines have changed.