Sentences with phrase «through phosphorylation»

The next slide, a little bit more about Fox01; Fox - 01, as I mentioned, is activated by Akt through phosphorylation.

Recent studies have established that nucleophosmin - ALK mediates oncogenesis, at least in part, through phosphorylation / activation of the serine / threonine kinase AKT (4, 5).

p38 MAP kinase pathway regulates apoptosis through phosphorylation and up - regulation of BimEL: ProQuest.

Since November 2013, as part of SGC, Clara mainly investigates different subfamilies of kinases involved in alternative splicing through phosphorylation - mediated regulation of SR proteins activity.

An InCytes from MBC Selection: Regulation of Cell Polarity through Phosphorylation of Bni4 by Pho85 G1 Cyclin - dependent Kinases in Saccharomyces cerevisiae.

Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin - dependent kinases in Saccharomyces cerevisiae.

Cyclin - dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons.

Interestingly, this anti-apoptotic function of ADAR1 is regulated through its phosphorylation by MAP kinases.

Not exact matches

One way for that to happen is through changes in gene expression, but changes in phosphorylation are equally effective,» explains Beltrao.

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

The types of stimuli that share this common effect on protein phosphorylation include numerous substances that do not act through cyclic AMP.

Regulatory T cells mainly dine on fatty acids and generate energy through an alternative pathway, oxidative phosphorylation.

«Pin1 changes protein shape through proline - directed phosphorylation, which is a major control mechanism for disease,» explains co-senior author Kun Ping Lu, MD, PhD, Director of Translational Therapeutics in the Cancer Research Institute at BIDMC and Professor of Medicine at Harvard Medical School who co-discovered the enzyme in 1996.

We have used systematic molecular bioengineering of the meningococcal LPS through deletion of enzymes involved in LPS biosynthesis in combination with induction of LPS modifying enzymes (for example the deacylase PagL) to yield a variety of novel LPS mutant strains with changes in both lipid A acylation and phosphorylation.

Also called OXPHOS Complexes (Oxidative Phosphorylation) that make redox NADPH be used as electron donor through ETC and allow mitochondria to produce cell energy ATP.

The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Amyloid - beta oligomers through Tau phosphorylation on S262.

To define the signaling changes resulting from each genotype, we isolated naive CD8 + T cells from mice deficient in DGKζ, Cbl - b, or both in DKO; stimulated the cells through their TCRs; and evaluated phosphorylation of Erk and phosphorylation and degradation of IκBα.

Oncoprotein YAP Regulates the Spindle Checkpoint Activation in a Mitotic Phosphorylation - dependent Manner through Up - regulation of BubR1.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

Mairet - Coello G, Courchet J, Pieraut S, Courchet V, Maximov A and Polleux F. (2013) The CAMKK2 - AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Abeta Oligomers through Tau Phosphorylation.

Kapoor P, Bao Y, Xiao J, Espejo A, Yang L, Bedford MT, Peng G, Shen X. (2015) Phosphorylation - Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex.

Mairet - Coello G., Courchet J., Pierault S., Courchet, V., Maximov A., Polleux F. (2013) The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers in vivo through Tau phosphorylation.

This activation partly occurs through, for example, phosphorylation of GSK - 3 which prevents its own inhibition of SREBP1c.

First, we will use our unique DNA - and chromatin - templated in vitro transcription systems to investigate the direct role of p53 serine18 phosphorylation in sestrin gene activation through modulation of p53 - coactivator interactions.

Interferons induce tyrosine phosphorylation of the eIF2 -LCB- alpha -RCB- kinase PKR through activation of Jak1 and Tyk2