Sentences with phrase «through signaling pathways»

These small molecules exhibit fascinating chemical diversity and regulate lifespan, reproduction, behavior and many other traits, often through signaling pathways that are shared throughout the animal kingdom.

The biomarker is normally regulated through signaling pathways called EGFR and ERK.

Not exact matches

Through numerous studies, Szyf has found that common signaling pathways known to lead to cancerous tumors also activate the DNA - methylation machinery; knocking out one of the enzymes in that pathway prevents the tumors from developing.

«This occurs when CSN6 is deregulated through a series of cellular signaling pathways.»

Researchers filled in other details about the selective role of LKB1 in regulatory T cells, including that the molecule unexpectedly works through the Wnt signaling pathway to adjust regulatory T cell function.

LKB1 is known to work through different pathways, primarily the mTORC1 and AMPK signaling pathways, in conventional T cells and other settings.

In testing multiple HDAC inhibitors in combination with the chemotherapy drug paclitaxel, known to give some benefit for this aggressive cancer, they found that class II HDAC inhibitors signal through a newly discovered pathway to promote synergy with chemotherapy treatment.

«The surprising part was that the mechanisms of resistance all funneled through one signaling pathway, ultimately, but the way that they start is frequently different,» said Dr. Aplin.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.

Looking at the mechanism downstream, the researchers found that the loss of Cbf - beta impeded the canonical Wnt signaling pathway, particularly through decreased Wnt10b expression.

But the researchers discovered that when the bacteria glom onto responsive colon cancer cells, the microbes boost a signal sent through a relay chain known as the beta - catenin pathway.

The researchers have some evidence that S. gallolyticus may also work through other chemical signaling pathways to enhance colon cancer growth.

Through many painstaking experiments, she zeroed in on a signaling pathway called Wnt, known to be important in mouse lung development.

«It turns out that the same signal — the so - called epidermal growth factor (EGF) pathway — control both the formation of pipes and beta cells through polarity changes.

Cohen's first breakthrough in this area occurred when he discovered, working with worms, that reducing the activity of the signaling mechanism conveyed through insulin and the growth hormone IGF1, a major aging regulating pathway, constituted a defense against the aggregation of the Aβ protein which is mechanistically - linked with Alzheimer's disease.

However, c - RAF has also been shown to activate signaling through the mitogen - activated protein kinase (MAPK) pathway.

One of the most exciting recent advances in clinical cancer research was the discovery that this subgroup of patients respond — sometimes dramatically — to a new class of drugs targeting the MAPK pathway through which BRAF signals.

«We concluded that RAC1 regulates lung branching morphogenesis, in part through the so - called canonical Wnt signaling pathway, which leads to the regulation of the transcription of many genes,» said principal investigator Denise Al Alam, PhD, of the Department of Surgery and the Developmental Biology and Regenerative Medicine Program at The Saban Research Institute.

Previously, longevity researchers believed dietary restriction was regulated via an insulin - signaling pathway, where the levels of the nutrient - sensing hormone would fall in response to lowered food intake, activating a DNA - binding protein called daf - 16 that would then confer longevity through the regulation of genes under its control.

We conclude that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life - span, and that in flies, insulin - like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue.

«We found that the well - known Notch protein is responsible for keeping blood vessels from becoming leaky, and does so through a secondary signaling pathway that operates in a completely different manner than its known transcription - based pathway,» says Chris Chen, M.D., Ph.D., Associate Faculty member of the Wyss Institute and Professor of Biomedical Engineering at Boston University, who is the corresponding author of the paper.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

Bohn's laboratory has pioneered the concept that KOR signaling can be fine - tuned to preferentially activate certain pathways over others so that the receptor signals through G proteins rather than through a protein called β - arrestin2.

For example, emotional responses have the potential to alter pain perception and modulation through certain signaling pathways.

The perception of music starts with specialised hair cells in the inner ear, which transmit sounds as electronic signals through the auditory pathway to the auditory cortex, where sounds are primarily recognised.

Still unclear is how enhanced signaling through the insulin pathway protects against obesity, although the researchers speculate that it might boost energy consumption by liver and muscle cells.

Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI - 1 Modulates Cell Migration through an IQGAP1 - Cdc42 - ARHGEF9 - Dependent Pathway.

Thrombosis recanalization by paeoniflorin through the upregulation of urokinase - type plasminogen activator via the MAPK signaling pathway.

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL - 22 — Qihang Hou — Cell Death and Differentiation

The tumor - suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK / Rho signaling pathways.

Cbl - b is an E3 ubiquitin ligase that targets multiple components of the TCR signal transduction pathway for degradation through the proteasome to facilitate termination of TCR signaling (19, 20).

Cutting edge: CD28 - mediated transcriptional and posttranscriptional regulation of IL - 2 expression are controlled through different signaling pathways.

In Ames dwarrf, Snell Dwarf mice, Klotho mice, GHKO mice who have little IGF and GH; and live longer than wild - type; we see that indeed insulin and glucose / nutrient / energy pathways (which create oxidative stress through excessive nutrient via elevated glycation blood glucose creating high glycated albumin and hemoglobin), that aging is acted on by IGF through hormones, GFs, GHs, acting on insulin signals, which act on survival genes (DAF / SIRT / FOXO).

Diverse signaling pathways through the SDF - 1 / CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis.

Lipoic acid restores age - associated impairment of brain energy metabolism through the modulation of Akt / JNK signaling and PGC1α transcriptional pathway.

The NAD (+) / Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

These receptors have been used in bacterial biosensors, where re-designed PBPs were linked to gene expression through a histidine kinase signaling pathway [5].

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

Citation: Antunes MS, Morey KJ, Smith JJ, Albrecht KD, Bowen TA, Zdunek JK, et al. (2011) Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway.

Go Deeper Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways Cre - dependent Selection Yields AAV Variants for Widespread Gene Transfer to the Adult Brain

Although triple negative cancer cells lack the three critical genetic markers that are currently used to guide breast cancer treatment, the scientists» analysis suggests a strong reliance on signaling through pathways similar to those that affect fetal breast stem cell growth.

The «HIF - 1 signaling pathway» also activates Glycolysis through the activation of different circuits that trigger effector proteins (PDK1, PFKL, ALDOA, etc.) with annotations such as glycolytic process, canonical glycolysis, glucose metabolic process, etc..

The «HIF - 1 signaling pathway» also inhibits Tricarboxylic acid cycle through the inhibition of circuits that trigger the effector protein PDHA1 with diverse GO annotations such as tricarboxylic acid cycle, acetyl - CoA biosynthetic process from pyruvate or carbohydrate metabolic process

Thus, leptin determines the extent of bone formation by modulating, via sympathetic signaling, osteoblast proliferation through two antagonistic pathways, one of which involves the molecular clock.

The fat body senses the concentration of intracellular amino acids through the activity of the Target of Rapamycin (TOR) signaling pathway, which in turn regulates the synthesis and secretion of an undescribed humoral factor (s), called the fat - body — derived signal.

The Herlyn Laboratory seeks to further define the various signaling pathways that work in cancer cells in order to discover new opportunities to inhibit cancer growth through targeted therapeutics.

It's been shown that actually for insulin to act on this receptor, it actually has to transiently inhibit PTPs in order to allow for a signal to be generated, but as soon as this signal goes through, this pathway is inhibited.

This is a very important lipid, that actually is involved in signaling, to many other kinases, and the key kinase that through this pathway gets activated is Akt; and Akt is a very important kinase that regulates many other factors.

Regulation of IL - 22 production by ILC3s is controlled through several well - described signaling pathways.