Sentences with phrase «through single genes»

Not exact matches

Europe came through: Last year, Cory received a European Molecular Biology Organization (EMBO) Installation Grant for his lab in mitochondrial biogenesis, and Gülayşe won a Marie Curie International Reintegration Grant from the European Commission to study how single genes can yield different protein products in neurons.

Jaenisch says that the method that identified the single point mutation in SNCA's enhancer could be used to pinpoint additional pathogenic genes for sporadic PD and sift through the GWAS hits for other diseases, including Alzheimer's disease, cancer, diabetes, and multiple sclerosis.

Because dogs appeared to inherit the disorder through a single mutation, Emmanuel Mignot and his colleagues at Stanford University Medical Center decided to sniff around in canine DNA for the flawed gene.

Through varied patterns of cutting and rejoining, a single transcribed gene can give rise to many different messenger RNAs, thus permitting a single gene to express different proteins.

In 1993 she proved that turning down the expression of a single gene, daf - 2, through genetic engineering doubled the worm's life span.

Throughout DNA processing, a single strand will go through countless modifications that determine whether certain genes will eventually be expressed.

That pattern of inheritance would suggest the strong effect of a single gene mutation, and it would most likely crop up in families that had a lot of shared genes through the intermarriage of first cousins.

«For the first time, we can predict the outcomes of modifying multiple genes involved in lignin biosynthesis, rather than working with a single gene at a time through trial and error, which is a tedious and time - consuming process,» says Jack Wang, assistant professor in NC State's College of Natural Resources and lead author of a paper about the research in Nature Communications.

Using the Single - Cell Automatic Analysis and Isolation System developed in 2013, this group isolated single OSNs responding to specific odorants in a time - lapse single - cell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction Single - Cell Automatic Analysis and Isolation System developed in 2013, this group isolated single OSNs responding to specific odorants in a time - lapse single - cell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction single OSNs responding to specific odorants in a time - lapse single - cell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction single - cell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction single cell polymerase chain reaction (PCR).

Gene moonlighting can occur merely through changes in expression, which may result from as little as a single mutation; it does not require the meandering process of random alteration and selection implied by the duplication and neofunctionalization model.

«The bad news about our finding is that it shows that resistance can arise through single mutations in one gene and pop up anywhere, at any time,» Dr. Fidock says.

It is surprising to find that a single gene (ESRP), through its ancestral biological role (cell adherence and motility) has been used throughout the animal scale for very different purposes: from the immune system of an echinoderm to the lips, lungs or inner ears of humans,» states professor Jordi Garcia - Fernàndez, of the University of Barcelona's Department of Genetics, Microbiology and Statistics and the IBUB.

Twenty years after he first stumbled on FOP, Economides and his colleagues report today that the gene mutation shared by 97 % of people with the disease can trigger its symptoms in a manner different than had been assumed — through a single molecule not previously eyed as a suspect.

Through the combination of linkage data and exome sequencing, they have identified a deletion or loss of a single base in the gene encoding STAG3, which results in a prematurely truncated protein without function.

«There are hundreds of candidate genes to sort through, and a single genetic variant may have different effects even within the same family.

Thus, in cases where users have a single gene they want to activate, we would recommend using a cDNA overexpression vector rather than going through all the troubleshooting required for Cas9 - based activation.

As an example, skeletal malformations and dysplasias, often detected through routine prenatal ultrasound examination, constitute a phenotypic finding in more than 300 syndromic and non-syndromic disorders and their genetic etiology may be due to a wide variety of genetic aberrations, ranging from copy number variations to single gene mutations.

Many scientists prefer to pursue cancer research through smaller - scale methods such as focusing on single genes.

Carrier testing can be ordered in various ways, including targeted single gene disease testing, panel testing of multiple genetic diseases, or less commonly through a broad genomic test looking for genetic variants throughout the genome or exome.

Furthermore, the levels of transcripts of two AlkB genes that protect against the cytotoxicity of methylating agents through repair of the specific DNA lesions generated in single - stranded DNA, Alkhb3 (alkylation repair homolog 3) and Alkhb8 (alkylation repair homolog 8), was lower in the IVC males.

The trouble until now was that there was no single screening test or system that could quickly sort through 20,000 genes, find the 15 needles in a haystack, and report out that data for each patient's case in an easy - to - read and simple report.