Pelham says that, as a recently tenured group leader, he learned
yeast genetics
through discussions with people in another
research group.
«It was remarkable that the compound rescued
yeast cells and patient neurons in similar ways and
through the same target — a target we would not have identified without
yeast genetics to guide us,» says Khurana, a postdoctoral scientist in the Lindquist lab and a neurologist at Massachusetts General Hospital who recruited patients for participation in this
research.