Sentences with phrase «thus signaling the cell»

The researchers investigated how Suv39h1 employs a positive feedback loop to chemically tag thousands of adjacent histones, thus signaling the cell to stow away these underlying, unnecessary DNA sequences.

Not exact matches

«The pathway mainly involves signalling via the brains» immune cells, and thus differs from how today's drugs operate.

Thus, signals coming from a given neuron provide information about odors that activate the specific receptor protein expressed by that cell.

Calcium is a «promiscuous» signal used by all cells for a wide variety of processes, he notes, and thus drugs that target it could have major side effects.

Rad3 signalling ensures that cells do not divide before DNA damages are repaired and thus provides cancer cells with a mechanism to resist chemotherapy by repairing these DNA damages.

The U-M study explains how increased cAMP in fat cells promotes the secretion of the hormone interleukin - 6, which signals the liver to stop producing glucose — thus improving overall blood sugar levels in obese diabetic mice.

It thus seems quite likely that this new signaling path also links the performance of the cellular power plants and cell division in human cells,» says Meisinger, who now plans to analyze these mechanisms in tumor tissues.

Kong and Crotty's team discovered that ICOS recruits the signaling TBK1 enzyme, which activates certain genes in Tfh cells, thus beginning the whole process of high - affinity antibody production.

In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step - by - step process that results in a precisely tailored and effective immune response.

Thus, the persistent synergid cell completely loses its pollen tube attracting function by synergetic SE fusion and ethylene signaling.

They provide the energy needed for communication between brain cells, which is crucial for transmitting stimuli and signals and thus for optimal functioning of the body.

Professor Heiko Lickert, director of the IDR, in collaboration with Professor Gunnar Schotta of LMU München, showed that the Wnt / β - catenin signaling pathway regulates Sox17, which in turn regulates molecular programs that assign pluripotent cells to the endoderm, thus inducing an initial differentiation of the stem cells.

«The inflammation factor TNFalpha suppresses the cGMP signal path and thus prevents white fat cells from being turned into brown fat cells.»

Tumors, for example, send growth signals to blood vessel cells to keep them growing and thus secure the blood supply to the tumor.

While retroviruses generally only infect dividing cells (because their access to the host genome is thought to rely on the breakdown of the nuclear envelope that occurs in mitosis [Roe et al., 1993]-RRB-, lentiviruses are a genus of the retroviral family that can infect non-dividing cells (possibly through the use of nuclear localization signals by the viral components [Bukrinsky et al., 1992]-RRB-, and thus, offer an advantage when transducing certain cell types that exhibit limited cell division (e.g., neurons).

These findings suggest that activation of mTOR signaling contributes to tumor cell survival in ALK + ALCL, thus providing a potential therapeutic target in this lymphoma type.

In tumour cells, the signals controlling cell growth and survival are dysfunctional, thus enabling the cells to grow in an uncontrolled manner.

A transcriptome research of its organs revealed its gene signature is highly evolved and adapted for extreme longevity (slow metabolism, improved insulin gene signaling and glucose homeostasis, thus reduced blood glucose, improved cancer genes, improved endothelial function by eNOS (endothelial Nitric Oxide Synthase) meaning improved vascular coronary blood flow, improved microvasculature arterial and heart endothelium function) but more importantly, to answer your question, some whales display low blood glucose hypoglycemia, this affects the quantity and period of proteins / DNA / cell exposure to glucose glycation, glycosylation and glycoxydation reactions.

Thus, lethal toxin - mediated down - regulation of IL - 22 was not due to reduced cell viability and instead suggested interference with a signaling pathway that regulates IL - 22 production.

This activity results in amplification of canonical WNT signaling in presumptive joint cells and perichondrium cells and thus in securing the non-chondrogenic fate of these cells.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Thus BBB cells are unlikely to receive CCHa2 signals or to relay the signals to the IPCs.

Thus we examined whether FGF signalling could alter the dynamics between the V + and V − states within the S + population by culturing HV cells in the presence of the FGFR inhibitor PD173074 [41] for 48 h.

When abatacept binds to CD28 on the T cell surface, it prevents the second signal from being delivered, thus turning down the T cell response.

Thus, lefty mutants have increased Nodal signaling resulting in increased endodermal and mesodermal gene expression and cell number during gastrulation (Meno et al., 1999; Rogers et al., unpublished).

The Notch system thus allows cells to receive signals from their neighbors and alter their gene expression accordingly.

A bioflavonoid found in cinnamon called proanthocyanidin may alter the insulin - signaling activity in our fat cells and thus has great potential for helping diabetes.

In addition, the chronic elevation of cortisol levels caused by excessive stress negatively affects the receptors for both insulin and leptin, which makes it harder for the body to read the signals of those hormones, thus keeping fat trapped in the cells and making you hungry all the time.

It's theorized that they can maximize the body's ability to synthesize more protein by signaling the muscle cell to call for and speed up the rate of protein synthesis, thus allowing the muscle cell to rebuild itself bigger or stronger, depending on your training goals.»

Cellular Solutions specializes in the design and implementation of Cellular Distributed Antenna Systems, DAS, to improve cell phone signal thus eliminating dropped calls.