Targeting intracellular human
thymidylate synthase in live cells, their pilot screen identified all drugs within the library known to act on this enzyme.
The relationships between oxidase and synthase activities of flavin dependent
thymidylate synthase (FDTS).
Functional analysis of substrate and cofactor complex structures of
a thymidylate synthase - complementing protein.
Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of
thymidylate synthase.
Later, it was learned that the drug actually works by blocking an enzyme (
thymidylate synthase) that the cells need for survival.