Conclusions
Thyrotropin levels within the reference range were positively and linearly associated with CHD mortality in women.
Of these, 192 women and 164 men had
thyrotropin levels within the clinical reference range of 0.50 to 3.5 mIU / L.
Methods In a Norwegian population - based cohort study, we prospectively studied the association between
thyrotropin levels and fatal CHD in 17 311 women and 8002 men without known thyroid or cardiovascular disease or diabetes mellitus at baseline.
Overall,
thyrotropin levels within the reference range were positively associated with CHD mortality (P for trend =.01); the trend was statistically significant in women (P for trend =.005) but not in men.
Treatment of patients with
thyrotropin levels at or below 10 mIU / L without symptoms may cause more harm than good and may represent overtreatment.
American Thyroid Association guidelines recommend considering levothyroxine therapy at
thyrotropin levels of 10 mIU / L or less when there are clear symptoms of hypothyroidism, positive thyroid autoantibodies or evidence of atherosclerotic cardiovascular disease (hardening of the arteries) or heart failure.
The study findings indicate that between 2001 and 2009, the median (midpoint)
thyrotropin level at the start of levothyroxine treatment declined from 8.7 to 7.9 mIU / L, with an increase in the odds of having levothyroxine therapy start at a
thyrotropin level of 10 mIU / L or less.
Compared with women in the lower part of the reference range (
thyrotropin level, 0.50 - 1.4 mIU / L), the hazard ratios for coronary death were 1.41 (95 % confidence interval [CI], 1.02 - 1.96) and 1.69 (95 % CI, 1.14 - 2.52) for women in the intermediate (
thyrotropin level, 1.5 - 2.4 mIU / L) and higher (
thyrotropin level, 2.5 - 3.5 mIU / L) categories, respectively.
Not exact matches
A study of patients in the United Kingdom suggests widespread prescribing of the medication levothyroxine sodium to boost thyroid function among patients with borderline high
levels of the thyroid - stimulating hormone
thyrotropin (a sign of low thyroid function), raising the possibility of overtreatment, according to a study published by JAMA Internal Medicine, a JAMA Network publication.
Effects of total energy withdrawal (fasting) on the
levels of growth hormone,
thyrotropin, cortisol, adrenaline, noradrenaline, T4, T3, and rT3 in healthy males.
Leptin,
Thyrotropin, and Thyroid Hormones in Obese / Overweight Women Before and After Two
Levels of Energy Deficit.
Triiodothyronine (T3) decreased at 12 months of follow - up, while thyroxine (T4) and
thyrotropin (TSH)
levels did not change significantly.
For the diagnosis of autoimmune thyroiditis, blood
levels of
thyrotropin (TSH), free thyroxine (FT4), and the titration of thyroid autoantibodies (TgAb and TmAb) were measured, and the thyroid gland was ultrasonographycally evaluated.
When thyroid hormone
levels are too low, your brain's hypothalamus releases
thyrotropin - releasing hormone (TRH), which stimulates the adjacent pituitary gland to produce thyroid - stimulating hormone (TSH).
When thyroid hormone
levels are low, the hypothalamus produces a hormone called
thyrotropin - releasing hormone or TRH.
Leptin
levels are dependent on sleep duration: Relationships with sympathovagal balance, carbohydrate regulation, cortisol, and
thyrotropin
For horses in early stages of disease with clinical signs, the
Thyrotropin Releasing Hormone (TRH) Stimulation test may be performed (with ACTH
levels measured before and after administration of TRH) as this test may be more helpful in diagnosing early disease.
In those animals with an equivocal change in basal hormone
level, the responses to challenge by exogenous
thyrotropin or adrenocorticotropin are subnormal, owing to the hypoplasia or atrophy of the thyroid gland and adrenal cortex.