Not exact matches
In a study completed in the UK, Doberman Pinschers treated with
pimobendan lived 6
times longer than those treated with an ACE inhibitor (329 days vs 50 days).7
In the QUEST Study,
pimobendan significantly increased the survival
time of dogs with congestive heart failure (CHF) caused by myxomatous mitral valve disease (MMVD).
The EPIC Study showed that administration of
pimobendan resulted in a 15 ‑ month delay in
time to primary endpoint compared with dogs receiving placebo.
Effect of
pimobendan or benazepril hydrochloride on survival
times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST Study.
The QUEST Study established
pimobendan as the new standard of treatment for dogs with congestive heart failure (CHF) caused by MMVD as it extended survival
time.2 The veterinary community also sought to answer this question: Can
pimobendan also delay the onset of clinical signs of CHF?
QUEST stands for Quality of Life and Extension of Survival
Time, and was an international, multi-centre clinical study comparing 2 treatments used to combat CHF in dogs,
pimobendan and an ACE inhibitor (benazepril hydrochloride).2
Median
time to composite primary endpoint was 1228 days in the
pimobendan group and 766 days in the placebo group (P = 0.0038).
In the EPIC Study, dogs in the
pimobendan group experienced 60 % more
time in asymptomatic stage B2 of heart disease and 10 % more life without CHF signs that impact quality of life (10 % more life without CHF was calculated based on an estimated lifespan for all small to medium ‑ sized dogs being 12.5 years.
Dogs in the standard - dose and low - dose
pimobendan groups had significantly longer median survival
times than dogs in the conventional group (334, 277 and 136 days, respectively; P < 0.001).
At that
time he was already on
Pimobendan, Furosemide (12 mg / kg / d) and ACEI.
Effect of
pimobendan or benazepril hydrochloride on survival
times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study.