Sentences with phrase «time development of»

Development of drugs resistance is a serious threat to global health and at the same time development of new antibiotics is facing serious difficulties.

S12), and the analysis of the time development of ion products (Fig. 3) shows that, in fact, two different ACC phases are precipitated — a more stable phase (ACC I) at high binding strength in clusters (pH = 9.00 to 9.50) and a less stable phase (ACC II) at low binding strength in clusters (pH = 9.75 to 10.0).

Time development of the free ion product.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

«The case is about their friendship, Judge, and these emails set out in real time the development of their friendship,» Gitner told U.S. District Court Judge Valerie Caproni, noting the men became friends following a fishing trip.

Looking at the short term volatility rather than the long time development of stock is according to Warren Buffet one of the most common mistakes among investors on all levels.

Not exact matches

(Disclosure: Time Inc., TIME and Fortune's parent company, was acquired by Meredith Corp. in a deal partially financed by Koch Equity Development, a subsidiary of Koch Industries InTime Inc., TIME and Fortune's parent company, was acquired by Meredith Corp. in a deal partially financed by Koch Equity Development, a subsidiary of Koch Industries InTIME and Fortune's parent company, was acquired by Meredith Corp. in a deal partially financed by Koch Equity Development, a subsidiary of Koch Industries Inc..)

Using this to my advantage, I have the benefit of picking and choosing what I want to offer, not sacrificing my time and money to do research and development.

Keep in mind that web development companies have other clients beside you and your project will not be the center of their attention at all times.

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

«Inspiring children through play and creativity is crucial to early development and no company has done more in that space over many generations than Mattel,» said Georgiadis in a statement «As a parent, I have seen this first hand and am honored to be joining the Company at this exciting time of renewed focus.»

Programs that provide skills development, mentoring and clear pathways to success from cradle to college and career, can generate benefits that are more than three times their costs, exceeding the rates of return seen in many private sector business investments.

«We've built a large research and development center near our main headquarters in Kyoto that literally houses thousands of developers with new recruits joining all the time.

By avoiding the task of employing extra staff members or handling operations such as payroll and web development, employees at a company will also be able to free up more time to focus on delivering their goods to their customers and carrying out the tasks that they were employed for in the first place.

«It's the first time people with an iPhone will be able to pick up the phone normally, or just listen to music, without any additional devices,» said Jan Janssen, senior vice president of research and development at Cochlear, in an interview.

People pleasing comes from a fear of rejection, failure or disappointing others, so it's time to examine where those fears come from and find a professional guide — a licensed therapist, social worker or psychologist who is knowledgeable in this area of personal development.

The opposite of failing fast is a «waterfall» approach to software development, where a significant amount of time is invested upfront — requirements analysis, design and scenario planning — before the software is ever tested with real customers.

These are some of the most significant developments in the oil saga for quite some time.

The Chinese are taking advantage of this development for the time being.

«Now I'm not asking for that right now, quite frankly I don't know if it is worth your time or our time to take this step on our end we're not in the business of doing just Custom Development Blueprints, one after the other.

At a time when debate about a potential outer harbour project south of Perth is building momentum, a look at the history of development in Kwinana's industrial zone provides an illustration of the impact of government intervention in the state's economy, for better or worse.

The company says this cuts design and development time in half, from months to weeks or days, for the finishing portion of jeans making.

Aged 14, he had won a fundraising competition run by charity World Vision and traveled from his home town of Melbourne, Australia to spend time in Manila to learn about international development.

Most successful entrepreneurs spend considerable amount of time working on their personal development.

Michigan is to work with Britain on the development of rules for self - driving cars, the Financial Times reported Monday.

Around this time, Hsieh was studying urban development and was especially influenced by Harvard professor Edward Glaeser's «Triumph of the City.»

Alice Ting, vice president of brand development, licensing and syndication told Bloomberg the Times expects the meal kit service to be at least as big as the Times» travel unit, where the paper's foreign correspondents act as tour guides in places like Iran and Cuba.

I suspect that had «World» gone into development after «Guardians of the Galaxy» came out, Pratt would have gotten a lot more screen time.

In the opinion of the Company's management, this measure is meaningful to users of the financial statements to understand the Company's periodic earnings and the variability of earnings caused by the unpredictable nature (i.e., the timing and amount) of catastrophes and loss reserve development.

Brent Taylor, Beyond Meat's VP of Corporate Development believes the firm's ability to focus on its core competencies has enabled it to grow rapidly without getting bogged down in such necessary time sucks as payroll, benefits and vacation time.

And that time is exactly what Gannicott needs to plot out the company's next phase: further development of the Lac de Gras region — and possibly an increase in Dominion's stake in it.

Cycling and running app Strava finds Glass well - suited for its users, who want real - time data on their workouts, said David Lorsch, vice president of business development.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Perhaps on Thursday a block of time goes into product development or content creation, and Friday could be allocated to networking and marketing.

Some examples of categories would be: - incoming and outgoing calls - email - marketing - website updates - bookkeeping - time with clients / customers - networking - writing content and articles - social media - product development

As far as wooing venture capitalists is concerned, More informs that Finzy's investors were following developments at the startup ever since the time of inception.

Higher than expected costs and longer development times, have hampered the project, which would create a unusual source of jet fuel.

Of course, not every Canadian life sciences firm will make it to the big time when it comes to drug development.

Rather than settle, Fantaay decided to alter his system's hardware, which cost him more than six months of product - development time.

«For the luxury car, it's their safe haven, it's their quiet time,» said Ky Tang, director of business development at Telenav.

For instance, assuming the SBA meets its goal of creating one job with every $ 50,000 of 504 lending — and the SBA says many Certified Development Companies exceed it — the cost per job in 2006 was a mere $ 188; the Treasury would earn that back many times in a single year's tax bill.

And if indeed some such culture arose on Earth in the murky depths of geologic time, how might scientists today discern signs of that incredible development?

The FTC's reported investigation into Facebook is the latest development in a scandal involving Cambridge Analytica, which The New York Times and The Guardian in explosive reports over the weekend revealed had access to the information of 50 million Facebook users.

By the time the fourth generation iPad hits shelves, we'll already have a good grasp as to whether the next decade of game development will belong to Canada — or someone else

Expert tip: When your large customer's procurement department says it must own all the technology created in your relationship, as well as enhancements to and development of that technology, it is time to call a well - seasoned licensing attorney to help you craft and negotiate customer license agreements and provisions that balance customer needs against possible leakage of your IP and your IP derivative works.

Factors which could cause actual results to differ materially from these forward - looking statements include such factors as the Company's ability to accomplish its business initiatives, obtain regulatory approval and protect its intellectual property; significant fluctuations in marketing expenses and ability to achieve or grow revenue, or recognize net income, from the sale of its products and services, as well as the introduction of competing products, or management's ability to attract and maintain qualified personnel necessary for the development and commercialization of its planned products, and other information that may be detailed from time to time in the Company's filings with the United States Securities and Exchange Commission.

Jim Jen of accelerator AlphaLab defines a true accelerator as a time - specific, mentorship - driven program designed to provide startups with critical resources to help them make rapid progress on product and customer development.

For instance, if we bring on a full - stack developer who we later learn will spend 80 % of their time working on backend development, we'll tell that person as soon as we can in order to prevent any surprises.

Now is the right time to bring in a CEO who will drive the next phase of Lululemon's development and growth.»

But the company has stumbled plenty of times in the past, and a watch doesn't preclude the development of other types of wearables, especially ones that might incorporate augmented reality.