Not exact matches
Get comfortable
with the firms» culture and most importantly, the
time they will dedicate to service your business in a prompt
manner.
You can waste your
time with an old business modeling approach — write a lengthy document and include lots of charts and data in it — or you can begin your entrepreneurship journey in a more professional
manner and use business model canvas.
These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree
with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on
time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely
manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company
with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.
EACH
TIME YOU SIGN IN TO OR OTHERWISE USE THE ONLINE SERVICES YOU ARE ENTERING INTO A NEW AGREEMENT
WITH US ON THE THEN APPLICABLE TERMS AND CONDITIONS AND YOU AGREE THAT WE MAY NOTIFY YOU OF OTHER TERMS BY POSTING THEM ON THE SITE OR ONLINE SERVICES (OR IN ANY OTHER REASONABLE
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time to file claims; (e) the
manner in which you communications
with us.
As the Fourth Industrial Revolution unfolds
with billions of people sharing a wide and deep array of data — texts, tweets, GPS coordinates, all
manner of photos, videos, environmental data, clickstreams, status updates, likes and reposts, pumping trillions of real -
time signals into the digital universe — what does the future hold?
Looking back at the three
times I faced this situation, I'm grateful I acted in a
manner congruent
with our stated company culture.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations
with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely
manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination
with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from
time to
time in Gilead's reports filed
with the U.S. Securities and Exchange Commission (the SEC).
If the material were to be presented in a
manner which melded training
with causes that truly interest students like Global Warming, species extinction, and catastrophic weather changes, it is more likely that they will be able to find
time outside of school to learn more of the necessary techniques.
For example, the expected
timing and likelihood of completion of the proposed merger, including the
timing, receipt and terms and conditions of any required governmental and regulatory approvals of the proposed merger that could reduce anticipated benefits or cause the parties to abandon the transaction, the ability to successfully integrate the businesses, the occurrence of any event, change or other circumstances that could give rise to the termination of the merger agreement, the possibility that Kraft shareholders may not approve the merger agreement, the risk that the parties may not be able to satisfy the conditions to the proposed transaction in a timely
manner or at all, risks related to disruption of management
time from ongoing business operations due to the proposed transaction, the risk that any announcements relating to the proposed transaction could have adverse effects on the market price of Kraft's common stock, and the risk that the proposed transaction and its announcement could have an adverse effect on the ability of Kraft and Heinz to retain customers and retain and hire key personnel and maintain relationships
with their suppliers and customers and on their operating results and businesses generally, problems may arise in successfully integrating the businesses of the companies, which may result in the combined company not operating as effectively and efficiently as expected, the combined company may be unable to achieve cost - cutting synergies or it may take longer than expected to achieve those synergies, and other factors.
The value of gold has the potential to always experience positive growth and if you are lucky to invest in gold at the right
time when the market value of gold suddenly experience a positive surge, you will for sure know how to make a million dollars and how to become a millionaire in one year if you are smart enough to invest
with the appropriate capital in timely
manner.
Many families relocate to more moderate tax environments or work
with the family office team and outside advisors to structure their wealth management in the most tax efficient
manner possible and may spend more of their
time in a different city or state than the one they had resided in prior to their financial windfall.
Sessions has mostly bitten his upper lip and looked the other way when Trump ripped him before, but this
time he pushed back in an official statement: «As long as I am the Attorney General, I will continue to discharge my duties
with integrity and honor, and this Department will continue to do its work in a fair and impartial
manner according to the law and Constitution.»
The only way to be in alignment
with changes is to see and evaluate the potential and
timing for these changes in an ongoing
manner, subjecting the analysis to various acid tests along the way.
I can not believe the ignorance and bias on this
with Statistics Canada - I mean come on people lets get
with the
times - you are operating a Statistical agency like we are living in the 1950's - this is indeed the 21st century - income polarization is a massive issue, and to report on income like the
manner that this article did is just out right garbage!!
'' «Best interest» means at the
time the annuity is recommended, acting
with reasonable diligence, care, skill and prudence in a
manner that puts the interest of the consumer ahead of the financial or other interests of the producer,» read the IRI definition.
Evolution does not affect overall entropy in a
manner inconsistent
with the laws of physics on a properly defined scale in space and
time — especially when you consider things like failed mutations, decomposition of organisms, etc..
InvivoSciences will continue to contribute to the improvement of human health by establishing a new paradigm for discovering drugs that focus on diseases
with limited treatment options such as cardiac fibrosis, scleroderma, and lupus in a
time - effective
manner while remaining safe and cost effective.»
They are using that good nature against us and every other civilized country in the world & its
time the we wake up and begin to deal
with them in a forceful
manner before its too late.
He argues for a «commensurable pluralism» that is to be understood in a
manner consistent
with the depositum fidei traveling through
time.
The process thinkers of our
time who have turned their attention to the religious question — the process theologians, as they are usually called — are sure, however, that there is another and sounder conception of God, one which makes love the clue to the divine nature and
manner of working in the world and one which is also in accordance
with what we know to be going on in that world.
I had been raised right,
with respect and reverence in the house, but at that
time I wanted to be cool and independent and dashing and dangerous and I wanted the other students to pay attention to me and think me cool more than I wanted to act in a
manner that I knew in my heart to be right.
Literally, hearing it meant that
with the passage of
time my mother's departure had become to me, in some inexplicable
manner, premature.
After drawing out how the encyclical applies this to various social, economic and ecological issues he highlighted, concerning «the problem of technology», that «this is the first
time an encyclical deals
with the subject in such an organic
manner -LSB-...] The exclusively technical mentality [and ideology] in fact, reduces all to pure doing... [True human development] requires a new perspective upon man that only the God who is truth and love can provide.»
Sixty - three percent of political and religious conservatives support allowing women and couples in the developing nations to determine the
timing and spacing of pregnancies in a
manner that includes the voluntary use of methods of preventing pregnancy — not including abortion — that are harmonious
with their religious values and beliefs.
It is only because God utterly transcends history that his free decision to become a human being in
time is also a decision of grace: «Far from implying a distance between the Word and the world, the Word's distinct
manner of transcending the world implies a distinct
manner of intimacy
with the world.»
Rather he centers his attention on the
manner in which the project residents, in the face of these horrors, nonetheless managed to make do, to «work
with others, sometimes productively and at other
times conflictually, to improve their living environment.»
Diodorus writes that, «For as regards the magnitude of the deeds which he accomplished it is generally agreed that Heracles has been handed down as one who surpassed all men of whom memory from the beginning of
time has brought down an account; consequently it is a difficult attainment to report each one of his deeds in a worthy
manner and to present a record which shall be on a level
with labours so great, the magnitude of which won for him the prize of immortality.»
All this has to be done very carefully and
with prayer so it takes
time to be done in a biblical and Christ like
manner
Often, Kernan would devote a significant part of his lecture
time to reading the text aloud, not in a highly dramatic
manner, but
with sensitivity to the texts» rhythms and semantic nuances.
One segment of the Christian Church lays Out its borders in a
manner inconsistent at
times with others».
It even expressed hope that God would lead them «in a
time and
manner of His choosing» years from now into altar and pulpit fellowship
with one another.
It is a strange and engrossing work, written in a
manner that many have compared to Tolstoy: stories within stories, huge chunks of raw material gleaned from the newspapers and agitprop pamphlets of the
time, seemingly endless speeches by would - be rulers in the doomed Duma, and all against the background of a weak and ineffectual Tsar dominated by his wife and «our Friend,» Rasputin,
with Lenin seething and scheming in Switzerland, waiting for his
time to come round at last.
One would think humans would have moved forward by now but instead we as a species behave in the same self - destructive
manner now as we did thousands of years ago
with more at stake then at any other
time in history.
If that, bad
manners aside, is what A.B. Yehoshua really had in mind, I agree
with him this
time, too.
We can not rest content
with the myth itself, in its literal sense; but we can get at what the myth was saying, and saying in a
manner appropriate to its
time and place.
Her first response to Schindler [6] is largely concerned
with chiding him for issuing a critique of West at the
time and in the
manner that he did.
And in case anyone forgets it's «that
time of year», I go overboard
with all
manner of scents, from cinnamon incense, to oranges and vanilla beans simmering on the stove, to Bath and Body 3 - wick candles in pine, vanilla and apple, all lit, first thing every morning from December lst on.
for Capek's comments concerning the
manner in which «Russell's hesitancies and discrepancies provide us
with beautiful illustrations of two complementary fallacies, pointed out by Bergson, concerning the nature of
time.»
After prep proceed to cook Aroborio rice in the usual way until it becomes the creamy Risotto we know and love: Sauté shallot in butter for just a few seconds / Add 2 C of rice and cook together for 1 minute / Add wine and cook until it nearly disappears, another minute or so / Season lightly now
with salt & pepper, and adjust when risotto is nearly finished / Add about half of the lemon zest and juice / Stir in simmering liquid 1/2 C at a
time until it just covers the rice / Allow rice to simmer, uncovered,
with occasional stirring until broth has «disappeared» into the rice, then add more liquid until rice is barely covered again and stir / Proceed in this
manner until rice is tender and creamy, about half an hour / Heat up additional broth or water if a little more is needed / When rice is tender or nearly so, adjust seasoning, add seafood, if any, and the rest of the lemon / Cook just a few more minutes until seafood is done / I like risotto «juicy» so I stop cooking while there's still plenty of liquid present / Optional: stir in 2 T of butter / Garnish
with fresh herbs like cilantro, dill or parsley, a slice of lemon.
For the first
time, armed
with the standard, countries and companies will be able to quantify how much food is lost and wasted, where it occurs, and report on it in a highly credible and consistent
manner,» said Andrew Steer, President and CEO, World Resources Institute.
We have Walnuts in our kitchen all year round, lovely to munch on as a quick snack but at this
time of year they really are brought to the forefront in the supermarket aisles in readiness for Christmas, along
with all
manner of nuts, some of which I will be highlighting over the next few weeks.
Into its 6th consecutive year, China Wine Expo continues
with its highly - lauded 2 - city formula - Beijing and Shanghai - allowing its exhibitors to market their wines in two of China's fastest growing regions - the Northern and Eastern - in a
time and cost effective
manner.
«The historical mission of our
times is to reinvent the human — at the species level,
with critical reflection, within the community of life - systems, in a
time - developmental context, by means of story and shared dream experience... The Great Work now, as we move into a new millennium, is to carry out the transition from a period of human devastation of the Earth to a period when humans would be present to the planet in a mutually beneficial
manner.»
Claudio Ranieri will undoubtedly be devastated
with the
manner of the defeat, but the Italian tactician will hope to oversee an immediate response when his side take on Norwich City in a fortnight's
time.
Everyone
time I defend this club (and having to do so against OUR OWN FANS is a completely different issue), one of the main points people always use to criticise Arsenal
with, is the utterly embarrassing
manner in which our own «fans» constantly attack the players, manager and the board.
i am not too bothered by the
manner we won today the most important thing is the 3 pts remember burnley beat liverpool not so long ago, also for the people who thought the title was already lost after just a few games (which by the way was stupid to think) well not only man city got beaten but their team looked jaded / tired and even though they have a very good squad they missed de bruyne terribly, it is not the same team without him they couldn, t create any chances which is good news, it can, t be good for a team to depend so much on one player (we should know a thing or two about this) in case he gets injured hopefully we have moved on from this and can deal
with injuries to our players in case it happens to us, we had our fair share and it is
time for us and to watch other teams getting depleted, COYG.
Lets continue
with the demonstrations but in a civilised and respectful
manner that, after all this
time, Arsene deserves and focus on the contract not his sacking.
In all fairness there's no shame losing to either of those teams (although the
manner in how we lost to Bayern last
time out was embarrassing for everyone associated
with the club).
we have become so tactically rigid that the
manner with which we approach most games have become overly predictable to even 1st
time managers!