The clinical presentation,
time of illness concurrent with the onset of the outbreak, and presence of neutralizing Abs in convalescent serum all strongly point to primary infection of the researcher by TMAdV.
Potential limits to external generalizability include the intensive research assessments (up to 12 hours), the recruitment and treatment
of patients in non — primary care academic settings, exclusion
of participants with substantial
concurrent psychiatric
illness and drug abuse, and the limited
time of treatment (16 weeks) given the chronicity and relapse potential in alcohol - dependent individuals.