Sentences with phrase «time the effect continues»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

In this study, the effects of sea level rise (assumed to continue at present, at the time of the study, rates, which the authors noted was likely conservative), wave fetch, wind speed and direction were examined and the resultant erosion rate was estimated for the Western and Eastern shore of Uppands, Port Isobel and Tangier Island by selecting 10 points along the western and eastern shoreline of all the islands.

Monetary policy: continued investment recovery, unemployment and inflation expectations are key; energy prices less so «The year - on - year rate of increase in the CPI is likely to be about 0 percent for the time being, due to the effects of the decline in energy prices.»

However, as one long - time evangelical leader told me, his community has also felt the continuing effects of cultural and social «intimidation» by the largely liberal and secular Oregon establishment.

At the same time that the church was dodging the potentially corrosive effect of freedom, it continued to demand the freedoms that the First Amendment promised.

At times the pain of drinking and the fear of the probable consequences of continuing outweigh the craving for alcohol's anesthetic effects and the fear of life without it.

Its effect was less the second time and continued to diminish as it was repeated.

My own hunch is that, so far as the Reformed churches are concerned, charismatics may continue as a small minority for some time to come, but the movement's principal effect on these churches has already been felt.

(c) The accreditation of a certifying agent shall continue in effect until such time as the certifying agent fails to renew accreditation as provided in 205.510 (c), the certifying agent voluntarily ceases its certification activities, or accreditation is suspended or revoked pursuant to 205.665.

We are also captivated with schizandra berry, hoping to get an energy boost from it and if it's all just a placebo effect, that the placebo effect continue for a very long time.

There are many times when third hand wishes his partner to continue the suit he has opened, and the natural way to effect that is by the play of a high card.

These are usually pretty strong over-the-counter medications and could have more adverse effects on your own body if you continue to take them over a longer period of time.

Although these processes will continue to change over time, parenting can have important positive effects even when children have inherited a genetic vulnerability to problematic behaviors.»

A full description of PROBIT's design and methods has been published elsewhere.17 In brief, 31 maternity hospitals and their affiliated polyclinics (where children are followed for routine health care) were randomized either to receive a breastfeeding promotion intervention modelled on the 10 steps to successful breastfeeding of the WHO / UNICEF Baby - Friendly Hospital Initiative (BFHI) or to continue the maternity hospital and polyclinic practices in effect at the time of randomization.

Methods: The Promotion of Breastfeeding Intervention Trial (PROBIT) randomized 31 Belarusian maternity hospitals and their affiliated polyclinics either to receive a breastfeeding promotion intervention modelled on the WHO / UNICEF Baby - Friendly Hospital Initiative or to continue the standard practices in effect at the time of randomization.

If you don't take care of him / her in the right way even though he behaves in the wrong manner, that effect will be seen in the future, because such behavior will be continued through out the future if you do not object at the right time.

Although I did continue to worry about nursing, I eventually gave up on timing nursing sessions; he never seemed to suffer any negative effects from it.

This effect was even more pronounced in infants who continued to be breast - fed also beyond the time of gluten introduction.

As the knock - on effects of benefit changes continue to be felt it's hard to see these figures coming down any time soon.

«While Mayor Warren has improved greatly, she continues to have lingering effects from her allergic reaction and her physicians are not ready to discharge her at this time,» said Communications Director James Smith, in a statement.

«We have been studying the health effects for such a short time that we can't say what the long - term outcomes will be for children,» Fenton continued.

If this pattern continues over time it will have an adverse effect on the CPS budget impinging on the organisations ability to effectively prosecute cases.»

Migraine days were significantly reduced within all three groups from baseline to post-treatment; the effect continued in the CSMT and placebo groups at all follow - up time points, whereas the control group returned to baseline.

The report is replete with examples of the social controversies involving science and technology at that time - the biological and environmental effects of nuclear weapons testing, DDT and other dioxins, the use of defoliants and herbicides by the U.S. military in Vietnam, the safety of nuclear power plants, the ban on fetal research, a moratorium on recombinant DNA research, the need for human subject protections and informed consent in genetics research, the misuse of psychology as a tool for torture, the implications of national security controls on science; misconduct in science, and the role of and protections for whistleblowers - many of which continue to resonate in the science and society relationship of today.

More research is needed to see if this shift in stage at diagnosis is a short - term effect or continues over time.

Nevertheless, «as time goes on, the cavitation effects from the bullet itself» are likely going to continue to kill off brain cells, Rhee noted.

«We found that all of these effects, which are the major ones from cratering, do not seem to supply enough nitrogen to supply the escaping atmosphere over time,» continued Singer.

Eberle and Kim said the early - middle Eocene greenhouse period from 53 to 38 million years ago is used as a deep - time analog by climate scientists for what could happen on Earth if CO2 and other greenhouse gases in Earth's atmosphere continue to rise, and what a «runaway» greenhouse effect potentially could look like.

In the time since the 2007 version of this report, the human effect on the climate has grown more than 40 percent stronger, thanks to continued emissions of greenhouse gases and more precision in measurements, with carbon dioxide leading the charge.

This generates a self - reinforcing effect of efficiency — the ants waste a lot less time and energy than they would in continued chaotic foraging.

Cohen continued: «This is because the global ecosystem in 2030 might still be in a transient, headed for much significant effects after time lags perhaps of the order of decades.»

I also hope that this research can be a model for future studies that continue to investigate climate change effects over time and space using the fossil record.

These risks and uncertainties include, among others, those relating to our ability to obtain sufficient financing to continue as a going concern, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, our ability to form collaborative relationships, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

These risks and uncertainties include, among others, those relating to our ability to obtain sufficient financing to continue as a going concern, the outcome of the review of the continued listing of our common stock on The Nasdaq Stock Market, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, our ability to form collaborative relationships, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

3:20 — Why as a doctor, he doesn't want to see his patients all the time 4:30 — The frustration that doctors face 5:20 — Why stress can be good and why we need it 5:45 — The physiological effects of too much stress 6:30 — How stress impacts fertility and memory 6:55 — The continued effects of stress on the body 7:50 — How to become more resilient to stress and how stress is like a light switch 8:28 — How to turn stress on and off 9:02 — Tips to Practically reduce stress (Book: The Relaxation Revolution) 9:45 — What is the relaxation response 10:20 — How to activate your relaxation response to deal with stress 12:45 — What happens when your body doesn't recognize stress 16:15 — What causes chronic pain 17:10 — Pain is all in the brain 17:45 — The biology of pain vs. the mental side of pain 20:00 — The core four for reducing stress and pain: Movement, Eating Right, Mindset, Avoiding Problems 24:00 — Understanding the mindset of doctors 28:00 — The frustration of the current medical system 32:00 — The shocking statistic on how a small percentage of the population is using 95 % of healthcare resources 35:00 — The seven questions you should know the answers to before you see your doctor 38:00 — Health advice Kevin wishes he had gotten earlier in life 41:15 — Kevin's recommended books and resources (and see below)

«Higher - intensity training can help you burn more calories in a shorter period of time, while also providing an EPOC (excess post oxygen consumption) or afterburn effect to continue expending energy even after the workout is over,» she says.

And most of all, before you decide to use drugs or accept a surgery read this article and information about your specific health problem in «Diseases» section of this site, implement the recommendations and use natural remedies or at least use them together with prescribed medication and as soon as you see improvements slowly and gradually reduce medication and at the same time continue using the remedies which do not cause bad side effects.

While these treatments won't give your complexion a permanent Benjamin Button effect, they will give you instant gratification unlike a serum or cream, which don't give visible results right away, but do eventually improve texture over time with continued use.

Regardless of what any other designer is doing - this, at a time where the Vetements effect is a crack that's still spidering out to several design houses - Sarah Burton continues to do «McQueen», and the thing about that is, no matter what feels zeitgeist - y, it still works and it still feels up - to - the - minute relevant.

It continues making excellent work of allegory, focusing on guns and their effect on people (or apes) this time around — a particularly poignant issue this year.

If research continues to show that comprehensive character education has positive effects on student achievement as well, then the movement may in time gain more robust political and financial support from education policymakers.

After termination, the program continued to have carry - over effects: in the 1996 — 97 school year, 442 students passed, about 11 times more than the number in the year before the program began.

«Using a simulation, every student can perform that actual experiment themselves in their own time, either in class, at home, on the way to school even, and can actually learn the experiments, the steps of the experiments and the relative effects, and even calculations within the experiment,» he continued.

The ripple effect of this grant had immediate impact throughout the district and will continue to reverberate for some time.

One might wonder why the Promise effects on the GPAs of African American students continue to increase over time rather than showing a one - time jump.

Advocates continue to emphasize that research shows that quality early childhood programs can have significant effects in terms of lower crime, improved educational outcomes and other quality - of - life factors, for at least some period of time.

(2) signed by an individual, or his parent, to the effect that he has been denied admission to or not permitted to continue in attendance at a public college by reason of race, color, religion, or national origin, and the Attorney General believes the complaint is meritorious and certifies that the signer or signers of such complaint are unable, in his judgment, to initiate and maintain appropriate legal proceedings for relief and that the institution of an action will materially further the orderly achievement of desegregation in public education, the Attorney General is authorized, after giving notice of such complaint to the appropriate school board or college authority and after certifying that he is satisfied that such board or authority has had a reasonable time to adjust the conditions alleged in such complaint, to institute for or in the name of the United States a civil action in any appropriate district court of the United States against such parties and for such relief as may be appropriate, and such court shall have and shall exercise jurisdiction of proceedings instituted pursuant to this section, provided that nothing herein shall empower any official or court of the United States to issue any order seeking to achieve a racial balance in any school by requiring the transportation of pupils or students from one school to another or one school district to another in order to achieve such racial balance, or otherwise enlarge the existing power of the court to insure compliance with constitutional standards.

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