Although the predominant feature of activity modulation during self -
timed saccades is a near linear decline in firing rate over time, other modulations are clearly present.
A similar response is also evident during the self -
timed saccade activity (blue, left), although the cause is likely due to a central saccade bringing the RF to encompass the peripheral target instead of target onset since first saccades are not included in the rhythmic analysis (Figure 4C).
Not exact matches
Sommer says future experiments may inactivate more of the thalamus to see if monkeys have a harder
time distinguishing their own
saccades from changes in their environment.
, real rat laughter doesn't tend to sound very much like the human variety, which normally involves pulsating sound bursts starting with a vocalized inhalation and consisting of a series of short distinct
saccades separated by almost equal
time intervals.
These rapid eye movements, known as
saccades, were
timed in all of the participants to see which of them were capable of making high numbers of express
saccades — particularly fast responses which begin a tenth of a second after a target appears.
The observation that activity is only correlated with the present interval implies that the correlations observed prior to central
saccades to
timing do not reflect past or future planning of peripheral
saccades.
Brief increases in activity just prior to
saccade onset are followed by short intervals of decreased activity at the
time of
saccades.
In order to determine what factors are associated with firing rate changes, we generated a prediction of neural activity by convolving observed neural activity aligned with one
saccade direction with the intersaccade distribution
times aligned with the other
saccade direction.
Around the
time of
saccade onset (± 100 ms), the activity displays distinct modulations.
The 800 ms intervals were investigated as that is the minimum
time for correctly made
saccades as defined by the error window (1,000 ms ± 200 ms).
If LIP activity strictly reflected a broad
timing system (like those described by centralized
timing models), its activity would have a consistent relationship with
time irrespective of
saccade direction.
Zero
time points and vertical black lines indicate
saccade onset.
After this memory - guided task, we recorded from the same neurons while the animals performed the self -
timed rhythmic -
saccade task (Figure 1A, B).
For each
saccade, the burst magnitude was quantified from the raw data by counting all spikes in the
time window between the two tick marks (identifying
saccade onset an offset with a 20 ms lead
time), and the resulting spike counts are displayed in the adjacent panels as running averages.
Yet, all these features taken together fully explain how the SC population could encode the nonlinear kinematics, and at the same
time generate straight
saccades in all directions.
We adopted a fixed lead -
time of 20 ms because this value corresponds with the typical latency of
saccades evoked by electrical stimulation at the recording sites.
For example, Reingold and Rayner [53] found that a reduced contrast leads to longer fixation
times for a critical word — amounting to an increase of first fixation
times by 60 ms and of gaze duration (i.e. the sum of all fixations on the critical word before the first
saccade to another word) by 120 ms.. This result was replicated in a subsequent study [54], which further showed that a reduced contrast leads to a lower probability of word skipping.