Sentences with phrase «times impact the effect»

Pre 2000 concensus — Increase in CO2 is a major climate forcing but there are other first order forcings out there which may at times impact the effect of CO2 or at other times offset it.

Not exact matches

GAAP earnings per share of $ 2.67, plus or minus $ 0.20, including the impact of wind energy restructuring and one - time tax reform effects;

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

The financial impact didn't come through in Box's second - quarter earnings, so investors will be looking carefully for any effect this time around.

Over time, as people became more and more aware of the effects commonly used products can have on the environment, plastic - happy clients who once cared mostly for cost and convenience morphed into savvy customers with real concerns about the impact polyethylene and other petroleum - based products have on the ecosystem.

It was slated to take effect on April 10, but Trump asked the department to review the rule one more time for its impact on investors.

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Actual results could differ materially from those expressed in or implied by the forward - looking statements contained in this release because of a variety of factors, including conditions to, or changes in the timing of, proposed real estate and other transactions, prevailing interest rates and non-recurring charges, store closings, competitive pressures from specialty stores, general merchandise stores, off - price and discount stores, manufacturers» outlets, the Internet, mail - order catalogs and television shopping and general consumer spending levels, including the impact of the availability and level of consumer debt, the effect of weather and other factors identified in documents filed by the company with the Securities and Exchange Commission.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Critics of the Fed's easy - money policies say they had diminishing impact over time and subjected the nation to side effects that could lead to serious problems in the future.

The stronger forecast is notable not just because it puts oil demand growth at its hottest in a long time, but also because the IEA essentially shrugged off any lingering effects from the storms in the U.S., concluding that the «impact on global markets is likely to be relatively short - lived.»

Even the latest major theological empiricists — Henry Nelson Wieman, Bernard Meland, and Bernard Loomer — did not have time to absorb the full impacts of the Kuhnian revolution in the philosophy of science, the neopragmatism extending from Willard Quine to Richard Rorty, the Continental movements of hermeneutics and deconstructionism, nor the epistemological effects that accompany the general demise of white, male, and Western hegemonies.

One could argue further that value has special socializing potency in the academy because of what sociologist Everett Hughes calls «the cloistering effect,» the powerful socializing impact on persons who live almost totally immersed for a period of time within one institutional setting.

The «Flexitarian» Effect: The rise of part - time vegetarians, who have reduced their meat consumption because of health, sustainability and animal welfare concerns, is having a major impact on new product activity.

This definitely has an impact on the players; they'll be worrying about their physical wellbeing (we see many times comments here say something to the effect that with so and so as ref in our upcoming match just wish we finish the game with no injuries — no doubt the players will be hoping they are just able to finish the match in one piece too — pretty sure some players will approach the match with this mind set).

By this time, the amount of dosage and its effects are already too negligible to make any impact.

This focuses on the fact that, with a huge disparity between paternity leave (2 weeks) and maternity leave (52 weeks), the current system penalises women by effectively forcing them into staying off work to look after the children, with a consequent negative impact on their earning potential; not to mention the limiting effect it has on men's ability to be active fathers at this crucial time.

With youth sports concussion safety laws in place in all 50 states, increased public awareness about concussions, and growing concernabout the long - term effect of repetitive head impacts, the demand for concussion education, not just for parents, coaches, and athletes, but for health care professionals as well is at an all - time high, and promises to go even higher in the coming years.

You do not want this hard time in life to effect your children and you want the impact to be as little as possible of course too.

Therefore, for the review's four primary outcomes we carried out subgroup analysis to explore the impact of interventions involving different types of supporter (professional versus lay person, or both); types of support (face - to - face versus telephone support or both); timing of support (antenatal and postnatal versus postnatal alone); whether the support was proactive (scheduled contacts) or reactive (women needed to request support); and whether support interventions had similar effects in settings with different background breastfeeding initiation rates (low, medium or high background rates).

The underlying logic of this stance is articulated with characteristic clarity by Larry Bartels, who has written: «In a world where most campaigners make reasonably effective use of reasonably similar resources and technologies most of the time, much of their effort will necessarily be without visible impact, simply because every campaigner's efforts are balanced against more or less equally effective efforts to produce the opposite effect.»

Ontario Premier Kathleen Wynne said at the time the deal will impact businesses in her province, and said she would advocate for Ontario to receive an exemption from the policy before it comes into effect, the Canadian Press reported.

The study, which is published today in Scientific Reports, used a mathematical model that takes into account whether people are naturally more of a morning or evening person, the impact of natural and artificial light on the body clock and the typical time of an alarm clock, to predict the effects of delaying school start times.

The brain - on - a-chip allowed the researchers for the first time to look at both the drug's impact on the individual regions as well as its downstream effect on the interconnected regions in vitro.

It was slightly better than in my regular TYR shorts, but nowhere near the PR I logged when I donned the racing suit for our editors the first time — all of which suggests that the embarrassment - avoidance effect had a meaningful impact.

A new reconstruction of Antarctic ocean temperatures around the time the dinosaurs disappeared 66 million years ago supports the idea that one of the planet's biggest mass extinctions was due to the combined effects of volcanic eruptions and an asteroid impact.

Ulnar collateral ligament (UCL) injuries in Major League Baseball (MLB) pitchers are high - impact due to player time lost and the resulting effect on teams and an athlete's career, making treatment decisions an even greater challenge for physicians.

These results suggest the same effect can impact a patient's learning and memory during a time when they are receiving critical information about their care.

It is the first time scientists have calculated the scale of the impact and its effects on Earth.

This is one of the first times that the considerable impact of age on pregnancy has been studied in detail beyond the effects of egg fitness.

At the same time, the 1.3 billion people without access to electricity and the 3 billion or so who still rely on burning wood or dung to fuel cooking or heating would need modern energy supplies, although this might prove to have minimal impacts on climate change through saving forests and other side effects.

While the authors» findings can not show causation or exclude the «effect - cause» that poor sleep could lead to more screen time, the association they found could fit with the theory that bedtime smartphone use may negatively impact sleep.

These effects are most relevant to policy makers keen to show the effectiveness of their interventions... Future work can assess the impact of SSB taxes on chronic diseases that would materialise later in time, such as heart disease, stroke, low back pain, and osteoarthritis, which would further strengthen the case for the SSB tax.

By definition, effects on reproduction and development — effects that could impact populations — can take time to emerge.»

The Intervenors requested supplementation of the FEIS on the grounds that the housing project was not planned at the time the impact statement was prepared between 1994 and 1997, and therefore any effects of HRI's operations on the people who will live in Springstead have not been analyzed as required by federal law.

These climate changes have measurable effects, like reductions in ground and surface water resources due to changing timing of precipitation and snowmelt, and measurable impacts like declining forest health and more wildfires, to altered crop seasons and greater irrigation demand.

-- 7) Forest models for Montana that account for changes in both climate and resulting vegetation distribution and patterns; 8) Models that account for interactions and feedbacks in climate - related impacts to forests (e.g., changes in mortality from both direct increases in warming and increased fire risk as a result of warming); 9) Systems thinking and modeling regarding climate effects on understory vegetation and interactions with forest trees; 10) Discussion of climate effects on urban forests and impacts to cityscapes and livability; 11) Monitoring and time - series data to inform adaptive management efforts (i.e., to determine outcome of a management action and, based on that outcome, chart future course of action); 12) Detailed decision support systems to provide guidance for managing for adaptation.

CO 2 equivalents: The GWP value (Global Warming Potential) of a gas is defined as the cumulative impact on the greenhouse effect of 1 tonne of the gas compared with that of 1 tonne of CO 2 over a specified period of time.

April is Parkinson's Awareness Month, a time intended to raise the visibility of a disease that effects an estimated five to ten million people world - wide and to share its personal, societal, and scientific impact.

Volcanic eruptions and impacts from celestial bodies, like asteroids, have a near instantaneous effect, but very few of these one - time events are of sufficient size to impact the global climate for more than a few years.

It's not necessarily obvious to the uninitiated what a huge effect this ~ 2ºC uncertainty in ECS estimates has on scenarios that attempt to predict the magnitude and timing of climate change impacts (e.g. the AR5 RCPs).

Research by German and Swedish experts investigating the effect of short - term sleep deprivation on hunger, physical activity and calorie metabolism found that too much time awake adversely impacts calorie consumption and body weight control by disrupting the delicate balance between sleep and hunger hormones.

3:20 — Why as a doctor, he doesn't want to see his patients all the time 4:30 — The frustration that doctors face 5:20 — Why stress can be good and why we need it 5:45 — The physiological effects of too much stress 6:30 — How stress impacts fertility and memory 6:55 — The continued effects of stress on the body 7:50 — How to become more resilient to stress and how stress is like a light switch 8:28 — How to turn stress on and off 9:02 — Tips to Practically reduce stress (Book: The Relaxation Revolution) 9:45 — What is the relaxation response 10:20 — How to activate your relaxation response to deal with stress 12:45 — What happens when your body doesn't recognize stress 16:15 — What causes chronic pain 17:10 — Pain is all in the brain 17:45 — The biology of pain vs. the mental side of pain 20:00 — The core four for reducing stress and pain: Movement, Eating Right, Mindset, Avoiding Problems 24:00 — Understanding the mindset of doctors 28:00 — The frustration of the current medical system 32:00 — The shocking statistic on how a small percentage of the population is using 95 % of healthcare resources 35:00 — The seven questions you should know the answers to before you see your doctor 38:00 — Health advice Kevin wishes he had gotten earlier in life 41:15 — Kevin's recommended books and resources (and see below)

The more people know, the greater the effect we can all have to work together and make a larger impact over time.

The best sweeteners, those that have little impact on blood sugar include the natural herbal sweetener called Stevia (100 - 300 times sweeter than table sugar without the toxic effects), agave, and lo han.

Not only do the effects of hirsutism take up a considerable amount of time to manage, it impacts quality of life and self - esteem.

Hormones and digestive ailments can impact the scale readings, time of the day effects weight, workouts can increase weight (due to retention of fluids caused by inflammation — a direct response of working out), even one glass of water can skew the scale numbers — and if those numbers aren't where you expect and want them to be, you can be thrown into a downward spiral of despair.

The Times Square face - off was good but as a whole the effects weren't near the impact level I was expecting.

A pastiche of action - movie pyrotechnics (film the explosion from three angles and use all of them — in fact, show the explosion blossom and fade from the front, then again in from the side, and then again from behind), this style creates a hyperbolic effect of maximum impact, all the time.