Allergic reactions such as hives happen when an animal becomes sensitized to a particular allergen, triggering formation of antibodies (immumoglobulin E, or IgE) that attach to specialized connective
tissue cells called mast cells and to blood cells called basophils.
However, research in Dr. King's lab has suggested a potentially more effective therapy that uses connective -
tissue cells called fibroblasts.
In fact, about a year ago, Jerry Shay and his colleagues at the University of Texas Southwestern Medical Center in Dallas showed that adding the enzyme to normal connective
tissue cells called fibroblasts extends their life - span (ScienceNOW, 13 January 1998).
The researchers — James Robl, a developmental biologist and his colleagues at the University of Massachusetts at Amherst, and Steve Stice at Advanced Cell Technology in Worcester, Massachusetts — inserted a marker gene fused with a gene for resistance to the chemical neomycin into a culture of connective
tissue cells called fibroblasts.
Ueli Schibler of the University of Geneva showed in 1998 that the per genes of rat connective -
tissue cells called fibroblasts are active according to a circadian cycle.
Not exact matches
But in the following hours and days, the body's self - defense mechanisms backfire: White blood
cells come in to clean up dead
tissue, which causes massive inflammation, which in turn triggers healthy
cells in the surrounding
tissue to self - destruct in a process
called apoptosis.
The building block electronic and protonic actual occasions are, in the case of human beings, swept into vastly more complex, Chinese box - like sets of containing societies within which there are social levels that can be identified with
cells, others which answer to Aristotle's levels of
tissues and organs, and which finally are presided over by what Whitehead refers to as the regnant nexus, a social thread of complex temporal inheritance which, Whitehead suggests, wanders from part to part of the brain, is the seat of conscious direction of the organism as a whole, and answers to what in Plato and Aristotle is
called the soul.
The female breast contains
cells called estrogen receptors which are stimulated by the presence of estrogen (or xeno - estrogens) into producing more mammary
tissue.
Cancer
cells travel around the body and begin to attack healthy
tissue in a process
called metastasis.
An armada of sentinel
cells,
called dendritic
cells, are decentrally positioned in
tissues to take up pathogens.
From the embryonic stem
cells, the researchers produced a type of
tissue called retinal pigment epithelium (RPE).
«If we want to treat the greatest number of diseases, we need to figure out how to get these molecules inside the
cells of patients — not just increasing the number of target
cells but also hitting
tissues other than the liver,» says Anderson, who co-founded a company
called CRISPR Therapeutics to pursue those goals.
This study built on previous research from the Sundrud lab, which showed that when TH17
cells entered the intestine in human
tissue samples, they increased the expression of a gene
called MDR1.
For unknown reasons our immune system attacks healthy
cells,
tissues and organs in a process
called autoimmunity, which can result in diseases such as multiple sclerosis, type 1 diabetes, lupus or rheumatoid arthritis.
These «organs on a chip,» as they are
called, are typically glass slides coated with human
cells that have been configured to mimic a particular
tissue or interface between
tissues.
The technique examines the small molecules, or metabolites, within
cells, bio-fluids,
tissue, or organisms and their interactions within the larger system,
called a metabolome.
These tests indicate that myomerger - deficient muscle
cells called myocytes differentiate and form the contractile unit of muscle (sarcomeres), but they do not join together to form fully functioning muscle
tissue.
A FATTY apron of
tissue called the omentum, which sits over the stomach and intestines, may be the perfect spot to grow patches of
cells for heart repair.
Ding's team took
cells called fibroblasts from the connective
tissues of mouse fetuses and bathed them in a cocktail of the four polyarginine - tagged proteins for 12 hours, then they removed the reprogramming proteins for 36 hours, and repeated this cycle four times over.
The team that included Gary Baker, an assistant professor of chemistry in the MU College of Arts and Science and Gerardo Gutierrez - Juarez, a professor and investigator at the University of Guanajuato in Mexico, decided to supplement an emerging technique
called photoacoustic (PA) spectroscopy, a specialized optical technique that is used to probe
tissues and
cells non-invasively.
The immune
cells appear to travel to the lens via a web of ligaments that suspends the lens and connects it to the surrounding muscle
tissue called the ciliary body, rich with immune -
cell - carrying blood vessels.
Finally, the team grew the
tissue in a three - dimensional system, which coaxed it into forming all the structures found in gut
tissue, including the finger - like villi that protrude inwards to increase surface area, and recesses
called crypts containing the intestinal stem
cells that renew the gut lining weekly (Nature, DOI: 10.1038 / nature09691).
One promising approach focused on a drug
called TOL - 101, which inhibits the immune
cells responsible for rejecting transplanted
tissue.
These were surrounded by skin - like
cells called fibroblasts, which form the heart's connective
tissue.
Within that sting lies a peptide
called chlorotoxin, which has an unusual property — it sticks strongly to tumour
cells while ignoring surrounding healthy
tissue, by binding to a cancer - specific protein
called matrix metalloproteinase - 2.
This sapwood consists of conductive
tissue called xylem (made up of small pipe - like
cells).
Cancer
cells are surrounded by other
cells called «stromal
cells», which can make up 80 per cent of pancreatic cancer
tissue.
A promising alternative to hESCs emerged in 2006 when researchers produced so -
called induced pluripotent stem
cells (iPS) from ordinary
tissue such as skin.
She «is willing to retract a paper concluding that so -
called STAP stem
cells can form a wide variety of
tissues, but does not intend to retract the paper describing how to make those stem
cells.»
He determined that a compound produced by the mold, which he
called penicillin, could kill pathogenic bacteria but not white blood
cells or human
tissue.
The technique,
called stimulated Raman scattering (SRS) microscopy, generates videos of moving
cells deep inside
tissue and could replace biopsies in the diagnosis of cancers.
Drugs that enhance a process
called oxidative stress were found to kill rhabdomyosarcoma tumor
cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of muscle and other soft
tissue.
The enzyme,
called tankyrase, may prove useful for extending the lives of cultured
cells grown to repair burned skin and other damaged
tissue.
These so -
called pluripotent stem
cells can be derived from a variety of adult
cells and be guided into almost any other
tissue type.
In addition, the polymer - based material,
called Parylene C, is less invasive and damaging to surrounding
cells and
tissue than previous microelectrode arrays comprised of silicon or microwires.
«Our data clearly showed that one of the protein receptors on white blood
cells called CXCR3 brings white blood
cells to the optic nerve in response to production of its binding partner CXCL10 by damaged nerve
tissue,» said Zhang.
What's more, the researchers discovered two years ago that the suppression of Esrp activity helps to enable a process
called the epithelial - mesenchymal transition (EMT), in which epithelial
cells acquire properties allowing them to detach and develop into new
tissue.
However, ChABC gene therapy decreased the presence of these
cells and increased the presence of other immune
cells called M2 macrophages that help to reduce inflammation and enhance
tissue repair.
Current thinking regarding type III hypersensitivity is that immune
cells within
tissues sense the presence of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors
called cytokines that activate the endothelial
cells lining adjacent blood vessels to promote the recruitment of neutrophils.
These transgenic stem
cells also readily created intestinal
tissues called «organoids» in laboratory dishes.
The same compound promotes the growth of tooth
tissue called dentine — a protective material between the sensitive pulp inside a tooth and the enamel on its surface — so Cohen believes that the type of
tissue formed partly depends on the neighbouring
cells.
In a boon to stem
cell research and regenerative medicine, scientists at Boston Children's Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Boston University have created a computer algorithm
called CellNet as a «roadmap» for
cell and
tissue engineering, to ensure that
cells engineered in the lab have the same favorable properties as
cells in our own bodies.
The challenge is to reprogram the energy storing white fat
cells into so -
called «brite» (brown - in - white) fat
cells in the body's white adipose
tissue and thus make adipose
tissue burn off excess energy as heat instead of storing it.
Since a primary function of the dendritic
cells is to present an antigen to T -
cells, to activate the T -
cells and begin the immune response, the researchers suspected that T -
cell activation in the heart
tissue, and perhaps heart -
tissue injury caused by T -
cells, might be central to the pathological heart enlargement that is
called remodeling.
Bones need a constant new creation of
cells specific to their
tissue, including the bone - producing
cells called osteoblasts.
By this time I knew that Grace had begun to exhibit various signs indicating destruction of the
cells of some of her voluntary muscle
tissue, a process
called rhabdomyolysis.
Reporting their data Aug. 6 in the journal Molecular
Cell, scientists at Cincinnati Children's Hospital Medical Center say the new technology —
called SpDamID — could allow scientists to answer basic questions about
tissue development and disease that existing technology can not address.
Tumours spread with the help of enzymes
called matrix metalloproteinases (MMPs), which destroy the connective
tissue between
cells and organs, allowing tumour
cells to break out of the original site and enter new ones.
In this study, Nicchitta and his colleagues treated
tissue culture
cells with a stress - inducing agent
called thapsigargin.
A study published by
Cell Press November 7th in the journal
Cell has revealed that an evolutionarily conserved gene
called Lin28a, which is very active in embryos but not in adults, enhances
tissue repair after injury when reactivated in adult mice.