This crosslinking mechanism has been used to produce tissue sealants from polymers that are commonly used in
tissue engineering studies — fibrinogen and gelatin (Elvin et al. 2011; Elvin et al. 2010), but so far, there have been relatively few studies using Ruthenium - mediated crosslinking for cell encapsulation.
Not exact matches
An associate professor in Northwestern University's medical school in Chicago and its
engineering school in Evanston, Illinois, Ameer
studies properties of materials that can mimic human
tissue, particularly materials that prevent rejection or scarring when implanted into humans.
Müller's diverse training prepared him to enter the field of biomaterials science, and today he directs the Department of Health Sciences and Technology's Institute for Biomechanics at the Swiss Federal Institute of Technology (ETH) Zurich, leading a multidisciplinary laboratory that
studies the structure and mechanical behavior of natural and
engineered tissues.
Tissue engineering provides a more practical means for researchers to
study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.
«One of the broader goals of our research is to make regenerative treatments more accessible and clinically relevant by developing easy, efficient and cost - effective ways to
engineer human cells and
tissues,» said Shyni Varghese, a bioengineering professor at UC San Diego and senior author of the
study.
The multidisciplinary team behind the current
study includes world - renowned researchers in the field of regenerative medicine and
tissue engineering; Paolo Macchiarini, MD, PhD, Director of the Advanced Center for Regenerative Medicine and senior scientist at Karolinska Institutet; Doris Taylor, PhD, Regenerative Medicine Research Director at the Texas Heart Institute; and Mark Holterman, MD, PhD, Professor of Surgery and Pediatrics at the University of Illinois College of Medicine in Peoria, working in collaboration with a research team at the Kuban State Medical University in Russia.
«To date, there has been no systematic means of assessing the fidelity of cellular
engineering — to determine how closely cells made in a petri dish approximate natural
tissues in the body,» says George Q. Daley, MD, PhD, Director of the Stem Cell Transplantation Program at Boston Children's and senior investigator on both
studies.
Meanwhile Coussens and her colleagues at U.C.S.F. found in a 2005
study, published in Cancer Cell, that the removal of antibody - making B cells from mice
engineered to be prone to skin cancer prevented the
tissue changes and angiogenesis that are prerequisites for disease progression.
To
study biopsied intestinal samples, the research team
engineered a microfluidic chamber where intact
tissues can be inserted in a known orientation.
Using this technique for
tissue engineering, he says, has been
studied for decades.
Tissue engineer Joan Nichols of the University of Texas Medical Branch in Galveston praises most of the
study.
Many diseases can be detected at the surface of
tissues, including cancer, while many pre-clinical
studies are performed with animal models and
engineered three - dimensional
tissues that can benefit from being monitored non-destructively.
One small
study reported promising results with
tissue -
engineered products to promote healing of diabetic skin ulcers.
«Our findings will provide a significant new tool for
tissue engineering, bioprocessing of stem cells and also for better
studying early development processes such as axis formation in embryos,» said Bratt - Leal.
«Scientists
tissue -
engineer functional part of human stomach in laboratory: Researchers can grow functional stomach and intestinal
tissues to
study diseases, new drugs.»
The
study is «a useful step in this effort to develop fully functional
tissues with blood vessels,» says chemical
engineer Abraham Stroock of Cornell University, who also works on
engineering blood vessels in
tissue using different techniques.
With a background in nuclear physics, Seifalian also
studied nuclear medicine and biochemistry before settling on
tissue engineering.
The
study is believed to be the first time human colon organoids have been successfully
tissue engineered in this manner, according to researchers at Cincinnati Children's Hospital Medical Center who led the project.
«Experimental orthotopic transplantation of a
tissue -
engineered oesophagus in rats» describes transplanting an esophagus into rats that was seeded with their own stem cells, and notes that all animals survived the
study period (14 days), and gained more weight than rats given a placebo operation.
As a postdoctoral fellow Dr. Olabisi
studied the biophysics of bone and seashell at Wisconsin's Synchrotron Radiation Center and bone
tissue engineering at Rice University.
Gold nanotubes
engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory
studies, and to distribute to
tissues within live mice as intended.
His current focus as the scientific lead is integrating various scientific fields to build interacting MPSs by interfacing platform
engineering &
tissue engineering for pharmacology
studies.
«This pairing of biology and
engineering allows us to re-create an intestinal lining that matches that of a patient with a specific intestinal disease — without performing invasive surgery to obtain a
tissue sample,» said Clive Svendsen, PhD, director of the Cedars - Sinai Board of Governors Regenerative Medicine Institute and a co-author of the
study.
Katja Schurig (Storch, TUD)-- «
Tissue engineering for reconstructing the central dopaminergic nigro - striatal pathway in Parkinson's disease: Cutting edge cell culture
studies» (2012)
Researchers will be able to
study samples ranging from
engineered nanoparticles and nanostructures to naturally occurring biological polymers,
tissues and plant cells.
James Sharpe is Head of EMBL Barcelona, which aims to
study the dynamic interactions of multicellular systems that underlie how
tissues build, maintain and fix themselves, how this can go wrong in disease, and how we can learn to build
tissues through
engineering.
He admits that this will take many years of basic biology research along with more translational
studies into
tissue engineering.
Embryonic stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical
studies in regenerative medicine,
Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal
Dr. Folkman's 1971 original hypothesis that solid tumors are angiogenesis - dependent initiated
studies in tumor biology that extended to disciplines as diverse as ophthalmology, cardiology, dermatology and
tissue engineering.
Nature Communications is publishing an editorial expression of concern on the manuscript «Experimental orthotopic transplantation of a
tissue -
engineered oesophagus in rats» from Sjoqvist et al. to alert our readership to concerns regarding the integrity of the
study.
Mooney uses the results from these
studies to design and synthesize new biomaterials that regulate the gene expression of interacting cells for a variety of
tissue engineering and drug delivery projects.
The team led by
engineering professor Sridhar Kota is
studying the muscle
tissues and internal organs of animals with no skeletons and have identified critical components known as elastofluids that will one day make it possible to create soft robots.