Sentences with phrase «tissue macrophage populations»
To test whether adipose tissue F4 / 80 + cells shared a common bone marrow origin with other tissue macrophage populations, we transplanted bone marrow from C57BL / 6J mice expressing the CD45.1 leukocyte marker into 6 - week - old lethally irradiated C57BL / 6J mice expressing the CD45.2 leukocyte marker.
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Expression analysis of macrophage and nonmacrophage cell populations isolated from adipose tissue showed that adipose tissue macrophages are the primary sources of TNF - α and other proinflammatory molecules in adipose tissue.
Of the three adipose tissue cell populations, the F4 / 80 + adipose tissue macrophages were the predominant source of TNF - α expression.
Nos2 was expressed by both macrophages and F4 / 80 — SVCs, and Il6 was detectably expressed by all three populations in adipose tissue.
To determine whether adipose tissue macrophages express any molecules implicated in obesity - associated complications, we isolated three cell populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched population, (b) a stromal vascular macrophage F4 / 80 + population, and (c) an F4 / 80 — stromal vascular population.