Sentences with phrase «tissue macrophages»
"Tissue macrophages" refers to a type of immune cell found in various tissues throughout the body. These specialized cells help the body by fighting off harmful bacteria, viruses, and other pathogens, and also play a role in repairing damaged tissue. Full definition
The accumulation of adipose tissue macrophages in direct proportion to adipocyte size and body mass may explain the coordinated increase in expression of genes encoding macrophage markers observed in our microarray expression data.
jci.org
HIV Persistence in tissue macrophages of humanized mice during ART.
Her groundbreaking research has shown that tissue macrophages often arise from embryonic precursors, challenging the established dogma that macrophages originate from adult bone marrow — derived monocytes that are circulating in the blood.
Deletion of the GM - CSF gene in the mouse led to reduction and impaired regulatory function of gut tissue macrophages and dendritic cells which compromised induction of tolerance to food antigens and increased mice susceptibility to IBD.
To test whether adipose tissue F4 / 80 + cells shared a common bone marrow origin with other tissue macrophage populations, we transplanted bone marrow from C57BL / 6J mice expressing the CD45.1 leukocyte marker into 6 - week - old lethally irradiated C57BL / 6J mice expressing the CD45.2 leukocyte marker.
Borgeson said one of lipoxin A4's key mechanisms of action is to switch the phenotype of the fat tissue macrophage cells from inflammatory to anti-inflammatory.
HIV persistence in tissue macrophages of humanized myeloid - only mice during antiretroviral therapy.
She showed that tissue macrophages have unique functional attributes that may have critical clinical implications, including a unique ability to resist genotoxic stress, which contributes to graft - versus - host disease and impacts tumor resistance to radiotherapy.
The researchers were also able to detect SIV DNA and RNA in the combined total SVF as well as in isolated adipose tissue macrophages and CD4 + T cells.
Macrophages that appear in fat are called «adipose tissue macrophages» (ATMs) and are thought to be the major players in controlling inflammation in obesity.
Tissue macrophages are derived from bone marrow precursors that migrate from the peripheral circulation.
Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.
The labeled HSCs rapidly contributed to committed progenitors of all lineages and to mature myeloid cells and lymphocytes, but not to B - 1a cells or tissue macrophages.
Instead, the culprits are two other kinds of cells that reside in fat tissue: preadipocytes and visceral adipose tissue macrophages (ATMs).
Obesity - induced inflammation is associated with increased adipose tissue macrophage (ATM) infiltration [22, 23].
Within 24 hours the virus multiplies in tissue macrophages and spreads via local lymphatics to tonsils and bronchial lymph nodes.