Sentences with phrase «tissue of origin»

Murchison and her team found striking similarities in tissues of origin, genetics, cancel cell mutation, and possible drug targets.

«Biologic models and early clinical evidence suggest that these fusions lead to oncogene addiction regardless of tissue of origin and, in aggregate, may be implicated in up to 1 % of all solid tumors,» wrote the study authors, led by Alexander Drilon, MD, of Memorial Sloan Kettering Cancer Center in New York.

«Ovarian cancer treatments have not changed much in many decades, and this may be, in part, because we have been studying the wrong tissue of origin for these cancers,» says study leader Victor Velculescu, M.D., Ph.D., a professor of oncology at the Johns Hopkins Kimmel Cancer Center.

What they did find, however, was that the two cancers, despite originating in different individuals, had similar mutational processes and similar tissues of origin, and responded to similar drugs.

To find out, Murchison and her colleagues took a closer look at the molecular features of the two cancers, and found similar patterns of mutation and tissues of origin for both.

«The molecular biology of the tumor is really leading the way over the tissue of origin.»

Conventional wisdom has long held that adult stem cells are only capable of forming their tissue of origin.

The new findings show that proper identification of a cell line also requires that the DNA profile matches the tissue of origin.

Scientists are beginning to identify cancer by its mutations rather than just its tissue of origin, allowing them to find drugs more precisely targeted to a particular disease type.

Sheltzer's team proposes that these cells rapidly evolved to acquire different mutations that would confer a survival benefit — perhaps enabling them to grow in new environments, just as cancer cells that become metastatic evolve so as to be able to detach from their tissue of origin and grow at different sites in the body.

Although senescent cells no longer divide, they persist in their tissue of origin and develop characteristics that can hasten and exacerbate age - related disease.

Both EETs and HETEs have markedly divergent biological effects depending on the tissue of origin.

Unlike embryonic stem cells, which are developmental blank slates that can generate virtually all types of cells found in adult humans, adult stem cells are thought to possess limited potential to transform into cells found in their tissues of origin.

In Gerard's view, this idea, that cancers take their identity from their tissue of origin, means that they can only be understood within that context.

These organoids recapitulate many aspects of their tissue of origin and allow the study of a multitude of physiological and pathological processes.

Cancers are usually classified by their tissue of origin and appearance.

The tissue of origin is not always clear and granular cell tumors may be of nerve (Schwann cell) origin.