Sentences with phrase «tissue therapy as»

Not exact matches

But as new methods of genetic modification emerge, both the scientific and the sports communities are becoming increasingly aware that gene therapy — the insertion of genes into an individual's cells and tissues — will make its way onto the playing field.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

Researchers said the importance of collecting tissue samples from recurrent tumors will grow as more targeted therapies become available.

Researchers can create iPSCs from a patient's blood or skin cells, and use these patient - specific cells to study diseases or even create new tissues that could be transplanted back into the patient as therapy.

Cancer therapies are often harsh because eradicating malignant cells entails damaging healthy tissue as well.

Two months after therapy, tissue analysis showed less scarring and higher levels of regenerative agents such as fibroblast growth factor — which accelerate healing — in rats treated with SIS plus stem cells compared with those treated with SIS alone.

The immediate payoff was a commercialization deal in age - related macular degeneration in which Pfizer became the first big pharma company to make a move into the use of embryonic stem cells as the basis for a tissue regeneration therapy.

Current therapy uses pacing devices such as pacemakers; however, many patients with advanced heart failure do not respond favorably to these devices because heart tissue must be healthy for optimal outcome.

But Fairburn's breakthrough is not a miracle drug that burns off adipose tissue as you watch TV, nor a molecular therapy to rid you of an «obesity gene».

«Cartilage cells (or chondrocytes) isolated and expanded from cartilage tissue have great potential as a cell - based therapy for patients with, for example, traumatic cartilage defects,» says Juha Piltti, doctoral student at the Department of Integrative Medical Biology.

Taken together, the results suggest a role for bile duct tissue microbiome in development of CCA and which may accordingly be used as a target for therapy.

While the clot - busting drug known as tPA (tissue plasminogen activator) had been the only medical therapy approved for treatment of acute stroke in the United States (U.S.), the projected U.K. cost savings of mechanical thrombectomy treatment as reported in the study could correlate to the U.S., making the treatment an even better option.

Because those organoids include stroma, a scaffold of connective tissue essential for tumor growth, they may prove better for studying therapies that target the stroma, such as cancer immunotherapy.

This makes adipose tissue, in theory, a readily available reservoir for regenerative therapies such as bone healing if doctors can get enough of those cells and compel them to produce bone.

Roybal reasoned that Notch could serve as a «sensor» able to detect disease or tissue - specific cues and initiate a more streamlined custom therapy.

It's not so much the amount of time elapsed since a stroke began as the amount of remaining at - risk but salvageable brain tissue that determines who will benefit from stroke therapy, he said.

For example, the camera could be used to visualize energy metabolism as it occurs within a cell's mitochondria or the way light passes through tissue, an important consideration for therapies that use lasers to destroy diseased tissue with the goal of leaving healthy tissue unharmed.

This promises to make proton therapy an option for thousands more cancer patients by reducing the risks of healthy tissue being damaged during treatment, particularly in vulnerable parts of the body such as the brain, eye and spinal cord.

In HIV - infected patients undergoing antiretroviral therapy (ART), ongoing HIV replication in lymphoid tissues such as the lymph nodes helps maintain stores, or reservoirs, of the virus, a new study funded by the National Institutes of Health suggests.

The interstitial pressure inside a tumor is often remarkably high compared to normal tissues and is thought to impede the delivery of chemotherapeutic agents as well as decrease the effectiveness of radiation therapy.

The biopsy of his primary tumor pointed to treatment with anti-HER2 therapy (Herceptin), but tissue from the metastatic biopsy, as well as cfDNA analysis, was negative for HER2 and positive for anti-epidermal growth factor receptor (EGFR) therapy (ABT - 806).

Using patient tissues obtained directly from operating rooms, the researchers found that the cells began to adapt to and resist therapies that target the growth pathway called mTOR in as little as 48 hours.

Selectively expressed on GBM and absent on surrounding brain tissue, the interleukin - 13 receptor α chain variant 2 (IL13Rα2) was identified as a potential target for therapy for GBM two decades ago.

«This advancement could be used for medical therapies such as personalized tissue patches to strengthen cardiac muscle tissue for heart attack patients.»

Purpose: The development of the UNC Immuno - Oncology Patient Centered Translational Research (IMPACT) Biorepository involves the collection of tumor tissue and blood, as well as data (e.g., demographic, clinical, questionnaire) from patients attending Oncology Clinics at UNC Hospital and undergoing immune therapy through participation in a Merck IT trial at UNC.

Among other things, we plan to include certain gene therapy products that permanently alter tissue and produce a sustained therapeutic benefit as part of the products that will meet the definition of being eligible to come under the pathway enabled by RMAT.

Now, using mice as their model, researchers at Johns Hopkins have developed therapies that increase blood flow, improve movement and decrease tissue death and the need for amputation.

The findings, published online the week of March 21 in the journal Proceedings of the National Academy of Sciences, demonstrate that nanoparticle - based therapies can act as a «precision medicine» for targeting tumors while leaving healthy tissue intact.

Regenerative medicine R&D efforts are focused largely on developing stem cell and tissue engineering therapies as a means to regenerate, replace or repair damaged tissues and organs.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

Cyclin A2: Increased levels of cyclin A2 have been shown to increase the regenerative capacity of heart tissue, one of an array of proteins that might for the basis for regenerative gene therapies for heart disease, and thus also might be beneficial to undergo far in advance of old age so as to slow or postpone degeneration in the heart.

We seek to «Track and Treat» the cancer cells present in patients» tissues by using lineage tracing, as well as sequencing technologies, to determine the molecular mechanisms responsible for the dissemination of cancer cells to various organs, and resistance to current therapies.

Due to the high efficiency of establishing organoid models from different tissues and diseases, such as cancer, organoid technology allows the generation of large living biobanks of tumor organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and xenograft - based drug studies (7,19).

With a focus on regenerative therapies for craniofacial problems, the Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration (C - DOCTOR) acts as an incubator for promising new technologies.

Cell therapy has been shown to be effective in reducing the infarct (scarring) caused by a heart attack as well as improving heart function when certain cell types are used — particularly cells from a person's own fat (adipose tissue).

As PD - 1 and PD - L1 targeting therapy continues in clinical development, our purpose was to better characterize PD - L1 tissue expression.

He is a major donor to and serves as an advisor to the Methuselah Foundation, dedicated to extending the healthy human lifespan by advancing tissue engineering and regenerative medicine therapies.

As the first approach lies beyond the scope of this database, further details of the cell therapy approach, including, to some extent, tissue engineering, are provided below.

The videos outline the forms of cell and tissue damage that are the root cause of aging and age - related disease, as well as the classes of therapy that could, once constructed, either repair that damage or bypass it entirely.

This special event is shared between Phacilitate Cell & Gene Therapy World and World Stem Cell Summit agendas, ensuring a unique audience made up of both industry and academic stakeholders as well as investors, big pharma, regulators and, of course, the world's leading cell and tissue banks.

«It provides up - to - date insights into recent regulatory developments, challenges to international harmonization, new perspectives on cell and tissue banking as well as critical reflections on the marketing of stem cell therapies, among many other themes.»

By studying them, we are beginning to gain insight into human disease — to understand why organs such as the heart can not repair themselves or why, as we age, the incidence of debilitating diseases such as cancer, heart disease and Alzheimer's increases so rapidly, and we are developing new therapies that will enhance our abilities to regenerate damaged tissues and prolong healthy lifespan.

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

In this overview, authors from AllCells provide deeper insight into supply - chain considerations for procuring and qualifying donated tissue as a starting material for generating clinical cell therapy products.

This sounds harmless and it's even possible it's a good idea but then replacing diseased tissue with healthy tissue, as they tried with Parkinson's Disease gene therapies, seemed like a good idea too.

San Diego, CA (March 31, 2009)-- Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as a cell therapy for diabetes, but also other endoderm lineage - derived tissues and organs such as lungs, intestine, liver, thymus and thyroid.

«We can use these cells and tissues as cell - based therapies and screening platforms, as well as to learn about heart development.»

Although they're typically used as a form of diagnostic imagery, ultrasounds can also be used as a form of physical therapy to promote healing in damaged muscle tissues and alleviate any associated pain.

This thing is one of my daily ways to relax because it combines the benefits of infrared heat, percussive massage, and vibrational therapy for what I can only describe as a mixture of deep tissue massage and myofascial release all in one device.

Similarly, cupping therapy can do the same thing for areas of the body with less fat tissue, such as the back and shoulders.