Sentences with phrase «tissue type of the tumor»

This bumped up sensitivity and allowed the team to home in on the tissue type of the tumor.

Not exact matches

A radiologist will then check the images of your breast tissue to see if it's most likely a fibroadenoma or another type of breast tumor.

By comparing the results to cells from paired normal tissue, researchers get a detailed molecular picture of the tumor environment, including the types and activity levels of T cells that are critical to the immunotherapy response.

To streamline this process, Uhlén's team has created standardized arrays containing microscopic samples from 48 kinds of normal human tissue and 20 types of tumors.

The authors acknowledge that «tumor tissue should be considered the preferred sample type when available, however, our encouraging results suggest that a single plasma - derived ctDNA sample may be considered appropriate for assessment of EGFR mutation status when tumor tissue is unavailable or exhausted.»

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

To illuminate the process, the Yale team sequenced normal, primary, and metastatic tumor tissue from multiple individuals, including subjects with a range of cancer types.

Because different types of tissue absorb emissions from the nanotubes differently, the scanner took readings from many locations to triangulate the tumor's exact location, as confirmed by later MRI scans.

This same feature, tumor heterogeneity, may reduce the ability to identify critical gene expression changes when comparing mean gene expression in adjacent tumor and normal tissues, as tumors of the same type may have different sets of genes differentially expressed.

Across all four cancer types, the new method of selecting candidate genes based on inter-tumor variation in gene expression outperformed the other methods, including the standard method of comparing mean expression in adjacent normal and tumor tissues.

A major challenge in creating any type of organoid is determining the unique mixture of nutrients, growth factors, and tissue culture techniques that will transform patient tumor cells into miniature tumor organoids in a petri dish.

Depending on the type of tissue, it plays different protective and mechanical roles, but it has also been shown to be involved in a number of diseases, including the growth of cancer tumors.

«Our work outlines the genetic similarities of the tissue and cells in different types of tumors and shows the strong relationships mice can have to other human cancers too.»

«The edge of a tumor is more challenging to detect than cancer versus healthy tissue due to a mix of different tissue types, and it is the edge that surgeons want to know about,» Ramanujam says.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

Researchers believe it is the largest epigenetic study yet for any single cancer type and, importantly, the first to use a large cohort of primary patient tumor tissues instead of cell lines grown in the laboratory.

Different types of tumors show a preference for specific organs and tissues; circulating breast cancer cells, for example, are likely to take root in bones, lungs, and the brain.

It is presently possible to differentiate about 100 types of CNS tumors based on tissue characteristics.

Stereotactic body radiation is a newer type of radiation therapy which delivers higher doses of radiation to the tumor but spares the surrounding tissue.

The tumor cells were all undifferentiated and hence provided a homogeneous peripheral field, in contrast to the cells of the normal limb bud, which were destined to differentiate into many types of tissue.

«Finding genomic similarities among types of breast, ovarian, endometrial and colorectal tumors once again reveals that cancer, although very complex, may have themes extending beyond tissue type that can be exploited for therapeutic benefit,» said Eric D. Green, M.D., Ph.D., NHGRI director.

«The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type,» by Mariia O. Yuneva et al., Cell Metabolism, Feb. 8, 2012.

LA JOLLA, CA — Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain...

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion critumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criTumor type specific exclusion criteria

Prostate cancer is a type of tumor that forms in the tissues of the prostate.

Embryonic stem cells derived from human blastocysts have the key advantage of pluripotency, meaning that they form nearly all cell types but also have the disadvantage of forming tumors in vivo, which may limit clinical application to tissue engineering rather than cell transplantation.

In a study published recently in Cell, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the body).

Clinicians also conduct clinical research and three current, ongoing studies include investigations into canine osteosarcoma, the most common bone cancer in dogs; soft tissue sarcomas, the most common type of solid tumors in dogs; and feline fibrosarcoma, injection - site tumors in cats.

The other type of tumor is malignant, which push through nearby organs or may spread to other tissues.

Definitive diagnosis of tumor type relies upon microscopic examination of tissue.

However, accurate diagnosis of the type of mammary tumor relies upon microscopic examination of tissue.

Clinically, skin tumors resemble several other types of tumor so definitive diagnosis relies upon microscopic examination of tissue by cytology or histopathology.

The selection of a radiation dose is based on considerations of tumor type, tumor location, and on the tolerance of the normal tissues surrounding the tumor.

Rabbits don't typically get this type of tumor that is composed of fatty tissue.

In the situation of this type of tumor, signs of heat are constant; they do not cycle as with ovarian tissue.

The remaining 15 percent are tissue overgrowths or other types of benign or malignant tumors.

Definitive diagnosis of tumor type relies upon microscopic examination of tissue samples.

The linear accelerator (LINAC) uses high energy targeted x-ray beams to treat many types of cancer, including nasal tumors, oral tumors, soft tissue sarcomas, and brain tumors.

Once the tumor has been removed, definitive diagnosis of the type of tumor, the stage it has reached and therefore prediction of its behavior (prognosis) relies upon microscopic examination of tissue (histopathology).

While some believe that these tumors are a soft tissue sarcoma, others have categorized malignant histiocytosis as a type of histiocytic sarcoma, which may be influenced by an abnormally large amount of histiocytes, a type of white blood cells that are integral to immune system functions.

There are various types of bladder tumors like squamous cell carcinoma (arise in the epithelial cells), adenocarcinoma (arise in the glandular epithelium), undifferentiated carcinoma, rhabdomyosarcoma (tumor of the striated muscle - form of fibers combined into parallel fibers like the skeletal and the cardiac muscles), fibroma (tumors made of fibrous or connective tissue.

Expression of VEGF has been reported in a wide range of different tumor types in the dog including hemangiosarcoma, malignant melanoma, soft tissue sarcomas, mast cell tumors, nasal carcinomas, intracranial neoplasias, and simple mammary gland adenocarcinomas and inflammatory mammary carcinoma.

Tumor types that may respond well to radiotherapy, or where radiotherapy can improve quality of remaining life by reducing pain, include mast cell tumors, sarcomas (cancer of bone, muscle or various connective tissue), lymphosarcoma, and tumors of the mouth, nose, brain and thyroid.

Perhaps the most frequently diagnosed of these is a neoplastic disease called meningioma, which is a type of tumor that develops in the thin protective tissue — the meninges — that covers a cat's brain.

Some common examples include other types of arthritis, tumors, fractures, soft tissue trauma, spinal pain (especially Cauda Equina Syndrome, which is often associated with arthritic changes at the spine), neurologic abnormalities and ligament, muscle or tendon injuries.

In dogs with primary tumors, the alkaline phosphatase (hydrolase enzyme responsible for removing phosphate groups from many types of molecules), alanine transferase (enzyme found in the liver and other tissues) are usually elevated.

Because tumors can develop from any tissue, there are many types of tumors that can occur in a variety of locations.

Mammary gland tumors can be either malignant (cancerous) or benign (non-cancerous) and arise from the different types of tissues (epithelial or glandular tissues, and mesenchymal or connective tissues) in the mammary gland.

Because tumors can develop from any tissue type, there are many types of tumors in many locations.

The University may still find the tissue useful in comparing other benign or malignant tumors of a similar type.