In their new study, they adapted DNA - PAINT technology to microscopes that are widespread among cell biology laboratories, called confocal microscopes, and that are used by researchers to image whole cells and thicker
tissues at lower resolution.
Not exact matches
But while PET scans provide
low resolution information with excellent depth penetration into living
tissues, the optical method introduced by the Tufts researchers detects metabolic activity
at the
resolution of single cells, although mostly near the surface.
Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps
at single nucleotide
resolution in a
low - passage breast cancer cell line and normal breast
tissue (primary human mammary epithelial cells).