Not exact matches
Scientists looking for new methods to make human
tissue have successfully used cloning technology to create
embryonic stem cells from skin
cells.
From the
embryonic stem cells, the researchers produced a type of
tissue called retinal pigment epithelium (RPE).
Da Cruz and his team grew replacement RPE
cells from human
embryonic stem cells on a thin plastic scaffold, before transplanting the
tissue into the back of each volunteer's eye.
Two people with severe sight loss can now see well enough to read after receiving
tissue grown
from human
embryonic stem cells.
Stem cells from breast milk can grow into many other kinds of human tissue, raising hopes of an ethical source of embryonic - like stem c
Stem cells from breast milk can grow into many other kinds of human
tissue, raising hopes of an ethical source of
embryonic - like
stem c
stem cells
ERRORS have occurred in a type of
stem cell that could be used instead of
embryonic stem cells — and in
tissues made
from them.
On the other hand, the problem is, you know, with
embryonic stem cells, they haven't been able to get
stem cell lines
from livestock animals that can proliferate in that way, without just sort of veering up in their own direction and turning into, instead of muscle, turning into brain
tissue or bone
tissue or something else.
Organlike
tissue bits can be generated
from pluripotent
stem cells that are either plucked
from embryos or created by taking a person's adult skin or blood
cells and chemically inducing them to revert to an
embryonic - like state.
The results help fill in the scientific puzzle kicked off by Dolly's cloning, which proved that mammalian egg
cells were capable of dissolving the genetic roadblocks that limit the potential of most adult
cells to give rise to only a single type of
tissue — that of the organ
from which they hail — whereas
embryonic stem cells have the potential to become virtually any kind of body
tissue.
Stem cells from adult bone marrow normally generate bone, muscle, cartilage and fat cellsa limited set compared with embryonic stem cells, which can spawn the full spectrum of adult tiss
Stem cells from adult bone marrow normally generate bone, muscle, cartilage and fat cellsa limited set compared with
embryonic stem cells, which can spawn the full spectrum of adult tiss
stem cells, which can spawn the full spectrum of adult
tissues.
The result — the second such finding in the past year — suggests that similar
cells from human testicles might have similar powers, paving the way to creating replacement
tissue for men who have suffered damage
from heart attacks or other injuries and avoiding some of the controversy surrounding
embryonic stem cells (ESC).
Last December, for instance, Chien's group reported finding markers for heart muscle
stem cells by tracing their development
from embryonic tissue.
The new approach builds on information gleaned
from developmental studies of
embryonic stem cells (see story # 16) and one day may be used to create healthy replacements for harmed or diseased
tissue.
Pluripotent
stem cells include
embryonic stem cells, which are derived
from early embryos, and induced pluripotent
stem cells, which are made by reprogramming
cells taken
from adult
tissues such as skin.
From an entire organ to a dose of embryonic stem cells, if the tissue's DNA came from anyone else, the transplant would be rejected without the aid of harsh immunosuppressive dr
From an entire organ to a dose of
embryonic stem cells, if the
tissue's DNA came
from anyone else, the transplant would be rejected without the aid of harsh immunosuppressive dr
from anyone else, the transplant would be rejected without the aid of harsh immunosuppressive drugs.
Moreover, if
embryonic stem cells were cloned
from the patient, he or she wouldn't have problems with immunological rejection of the cultured
tissue.
Specifically, the researchers generated the
tissue from human
embryonic stem cells with the resulting muscle having significant similarities to human heart muscle.
Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor
cells derived
from embryonic stem cells and
from human fetal brain
tissue can successfully create myelin sheaths around nerve
cells, sometimes leading to dramatic improvements in symptoms.
This has always been a worry with
tissues produced
from embryonic stem cells, as these have the capability to form tumours if any are left in their original state in the transplanted
tissue.
The research used skin samples
from five men to create what are known as induced pluripotent
stem cells, which closely resemble
embryonic stem cells in their ability to become nearly any
tissue in the body.
The potential of iPS
cells to help treat everything
from damaged heart
tissue to Parkinson's disease, has prompted intensive research that has looked into the use of skin fibroblast
cells as an alternative to controversial
embryonic stem cells.
This finding complements previous research
from the University of Edinburgh and the National Institute for Medical Research which showed that
embryonic stem cells can be coaxed into this spinal cord
cells; however, the Cambridge researchers showed that the in the embryo - like aggregates, the structural organization is more robust and allows for the polarised growth of the
tissue.
iPSCs are
cells that can be take
from adult
tissue and «reprogrammed» into
embryonic stem cell (ESC)- like
cells.
A research team said it has produced stratified retinal
tissues from human
embryonic stem cells for the first time in...
2007 also saw one of the most game - changing developments in the
stem cell field; researchers learned how to create
cells like
embryonic stem cells, but instead of coming
from an embryo these
cells are created
from adult
cells, potentially
cells from any
tissue in the human body.
A human
embryonic stem cell is reined in — prevented
from giving up its unique characteristics of self - renewal and pluripotency — by the presence of a protein modification that stifles any genes that would prematurely instruct the
cell to develop into heart or other specialized
tissue.
iPSCs are
cells that were originally
from adult
tissues, but have been forced to produce proteins that are thought to be essential for the pluripotency of human
embryonic stem cells.
Stem cells harvested from amniotic fluid and placental tissue are readily obtainable and have properties of both embryonic and adult stem ce
Stem cells harvested
from amniotic fluid and placental
tissue are readily obtainable and have properties of both
embryonic and adult
stem ce
stem cells.
Because the
cells were derived
from human embryos or fetal
tissue, pro-life groups condemned
embryonic stem cell research as morally wrong.
InvivoSciences makes engineered heart
tissues from mouse
embryonic stem cells and
stem cells from differentiated adult
tissues in humans, such as fat and skin.
Both human
embryonic stem cells (hESC) and induced pluripotent
stem cells (iPSC) can colonize the mouse embryo in a manner predicted
from classical developmental fate mapping and faithfully recapitulate
tissue - specific fate post-transplantation.
Adult
stem cells were once believed to be more limited than
embryonic stem cells, only giving rise to the same type of
tissue from which they originated.
Embryonic stem cells derived
from human blastocysts have the key advantage of pluripotency, meaning that they form nearly all
cell types but also have the disadvantage of forming tumors in vivo, which may limit clinical application to
tissue engineering rather than
cell transplantation.
Mouse
embryonic stem cells derived
from the epiblast contribute to the somatic lineages and the germline but are excluded
from the extra-
embryonic tissues that are derived
from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst.
Prof. Dr. Ivan Martin's research group at the Department of Biomedicine has now been able to demonstrate that by forcing certain molecular events occurring during the
embryonic development of articular cartilage it is possible to generate stable cartilage
tissue from adult human mesenchymal
stem cells.
Neural
stem cells are found in adult or fetal brain and spinal cord or derived
from embryonic stem cells, which have the capacity to become any
cell type in the body, or induced pluripotent
stem (iPS)
cells,
tissue - specific
cells that are reprogrammed in the lab to behave like
embryonic stem cells.