Sentences with phrase «to accumulate mutations»

The researchers will now continue their work to investigate whether physical exercise can affect the number of accumulated mutations.

Accumulated mutations in the virus genomes reveal that the outbreak began well before the medics arrived in the country.

Mutations take place at random, and the two duplicates accumulate mutations at different locations, so that divergence takes place.

Because the viruses accumulate mutations as they reproduce and spread, differences between their genomic sequences can be used like a molecular clock to estimate how long ago they last shared a common ancestor.

By obtaining outer thigh muscle biopsies from healthy volunteers and sequence the satellite cell genomes, the team was able to demonstrate that these stem cells accumulate mutations during life.

One gene in giant pandas, TAS2R42, had accumulated mutations with incredible speed compared with their other genes — a telltale sign that natural selection had favored these mutations.

When Larsson engineered mice with a defective, error - prone version of the protein, mice accumulated mutations unchecked.

Hutchison and Edgell guessed that this was because the switch that allows a gene to be turned on or off — the so - called promoter — has become faulty from accumulated mutations.

In these patients, the virus evolved over time, indicating ongoing replication, but did not accumulate mutations conferring drug resistance.

«Genomes accumulate mutations over time, some of which don't change the structure of associated RNAs.

There, with help from Wasser and his colleagues in Seattle, geneticist Al Roca sequenced introns — vestigial sections of DNA from the nucleus that accumulate mutations quickly because they don't code for any physical traits — and confirmed that forest and savanna elephants diverged at least 2.6 million and probably more than 3 million years ago — long enough to render them separate species.

Mutations in these animals began to amass during embryonic development, while normal animals don't begin to accumulate mutations until after birth.

How are microbial communities assembled in the > 5,000 - y - old subsurface of marine sediment, and do they undergo adaptive evolution or accumulate mutations due to impaired DNA repair under such energy - limited conditions?

There, Michor began studying the evolution of cancer, unraveling, for example, the time required for cancer cells to accumulate mutations in a class of genes that safeguard against cancer.

But the researchers discovered that in the fly, Odysseus has been accumulating mutations at up to 1000 times the normal rate.

Meanwhile, Esvelt and his colleagues are studying the CRISPR gene - drive system in the nematode Caenorhabditis elegans to learn more about what happens to a population as engineered DNA is passed down through generations, accumulating mutations as it goes.

However, the regenerative capacity of stem cells declines with age and stem cells accumulate mutations that clonally expand and pre-dispose to the development of diseases and cancer and an overall increase in mortality.

«So the eye isn't destroyed because of accumulated mutations but is destroyed from the outside,» Jefferey says.

Those made with iPS cells, by contrast, tend to accumulate mutations and suffer abnormal patterns of gene activation.

On average, every duplication of the human genome includes 100 new errors, so all that reproducing gave our DNA many opportunities to accumulate mutations.

The African strain has been accumulating mutations that allow it to be spread more easily by Aedes albopictus.

Over the last 6 million years, those accumulated mutations have inactivated several genes.

To identify the accumulated mutations that restored viral fitness, the researchers sequenced the viral RNA using a supersensitive method called PrimerID sequencing, which enables tracking of all individual viral genomes so that any relevant mutations can be spotted.

Taken together, these findings suggest that BRCA2 mutations increase susceptibility to breast cancer by disrupting DNA repair and allowing cells to accumulate mutations, including those that foster cancer development.

Genes known to accumulate mutations at a constant rate, much like a ticking clock, can be used to determine when a species originated.

«Following the process described by Yamanaka the reprogramming took weeks, had a very small success rate and, in addition, accumulated mutations and errors.

The girl's lineage had less time to accumulate mutations, and the «missing evolution» suggests she died about 80,000 years ago, although the date is tentative, says co-author David Reich, a population geneticist at Harvard University.

Recent studies have shown that intestinal stem cells, which last a lifetime, are the cells most likely to accumulate the mutations that give rise to colon cancer.

Approach: The basic idea of GESTALT is to introduce CRISPR - Cas9 into dividing cells and track the cells as they accumulate mutations in each subsequent generation of cells.

Most us accumulate these mutations, which are usually innocuous but sometimes harm important genes.