Sentences with phrase «to activate a receptor»

If a fatty acid activates the receptor, it triggers a negative effect: the heart rate and the force of muscular contraction are reduced.

FDA - approved in 2015, eluxadoline (Viberzi) helps control IBS - related diarrhea by activating receptors in your nervous system that reduce bowel contractions.

In a major innovation reported last year, Lerner, Zhang and their colleagues developed a basic method for selecting antibodies that not only bind to a given target, such as a cell - surface receptor, but also have a desired biological function — such as activating the receptor on mammalian cells.

Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 antibody

Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 3ext antibody

Kalbe and co-workers then determined how activating the receptors with the odor molecules affected the isolated smooth muscle cells.

He says that drugs such as zolpidem, manufactured by Sanofi - Aventis, activate receptors for the neurotransmitter gamma aminobutyric acid (GABA) in the brain.

According to researchers at the Johns Hopkins University School of Medicine, these chemicals lower blood pressure by activating receptors in the blood vessels.

Rimando A. Pterostilbene as a new natural product agonist for the peroxisome proliferators - activated receptor alpha isoform.

Leukemic cells can feed themselves through increased secretion of hepatocyte growth factor (HGF), which then activates its receptor, MET, to promote growth.

«What we were interested in is: Could you locally activate the receptor naturally at a level that would cause only modest AHR activation in the gut, but not cause systemic activation, which could possibly lead to negative effects?»

Black people are particularly at risk, given the study's finding that suPAR activates its receptor on kidney cells that then attract the APOL1 risk proteins.

They gave some of the rats flutamide, which blocks testosterone from activating receptors in the brain, and gave others tamoxifen, which blocks estrogen receptors, finding that the drugs lessen the anxious behavior in the rats.

Sex difference in hepatic peroxisome proliferator - activated receptor α expression: influence of pituitary and gonadal hormones

Reversing vascular dysfunction in rheumatoid arthritis: improved augmentation index but not endothelial function with peroxisome proliferator - activated receptor γ agonist therapy.

Calcium and glutamate can activate the receptor like there is no tomorrow.

The hippocampus receives signals from the orbital frontal cortex (OCF) that may increase sensory stimuli when growth hormone activates receptor cells

To determine which of the two receptor populations — the one in the forebrain or the one in the brainstem — is most critical in that regard, the team then crossed the knockout mice with a line engineered to activate receptor expression in particular brain regions.

T cell engagement is mediated via CD3, NK cells are engaged via activating receptors such as ULBP2.

It also stimulates the production of a hormone known as adiponectin, which activates a receptor known as the PPARα receptor.

These peppers contain so much capsaicin that the chemical permeates the blisters and keeps activating receptors in the nerve endings underneath, causing ferocious burning sensations for 20 minutes or more, Bosland said.

A protein called peroxisome proliferator — activated receptor g co-activator 1 - alpha (PGC1 - alpha) regulates the expression of many genes identified by the researchers.

«When we gave the compound that specifically activated the receptors, we saw a robust increase in feeding,» Chen says.

«In most other hormone - receptor systems, the hormone directly activates the receptor protein,» says Antje Brüser, first author of the study and junior scientist of the group, offering the example of how adrenalin activates the ß adrenergic receptor.

Through this test, we saw that in mice, activating our receptor made the reaction much, much worse,» says Dong.

When G - CSF activates its receptor, it ultimately activates proteins called STATs; the team engineered the cells to churn out the light - generating protein luciferase, which would be turned on by the STAT molecules.

Glutamate and glycine activate the receptor, which is an important mediator of brain signaling for processes such as learning and memory.

Glutamate activates receptors on neighboring cells, causing them to propagate the wave and release ATP.

«Both glucocorticoid hormones and antidepressants activate this receptor, but they do so in very different ways,» says Anacker.

And when the researchers from Ruhr - University Bochum in Germany activated these receptors, they found that they regulated the way in which the airways smooth muscle cells contracted.

They found that the mutated G1 and G2 variant did so particularly well on what's known as a receptor on the surface of kidney cells, in this case the suPAR activated receptor alphavbeta3 integrin.

The feces also seemed to contain a more «pro-inflammatory» microbiome, meaning bacteria more strongly activated receptors that trigger inflammation — though it's not yet clear which bacteria have this effect.

«Before, activating this receptor inhibited the secretion of orexin; now it promotes it.

When Chen and his colleagues activated both receptors simultaneously in mice, the rodents scratched much more than if the itch - inducing receptor was turned on alone.

Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells.

Like a guard pulling a fire alarm, AMPK activates a receptor on the outside membrane of a mitochondrion to signal it to fragment.

He is looking to find whether activating the receptor — transient receptor potential vanilloid - 1, or TRPV1 — on the immune cells that rush to the ailing brain, can reduce the lingering inflammation associated with problems like poor cognition and depression in the aftermath of a TBI.

Artificial sweeteners taste sweet because their chemical structure activates receptors on the tongue for sweet taste.

Chronic engagement of Natural killer cell inhibitory receptors by MHC - I molecules maintains a high activity of the mTOR pathway allowing subsequent amplification of signaling through activating receptors upon acute stimulation.

This surge of endorphins helps activate receptors in the blood vessels that suppress pain and also triggers a rise in T - cell count, which is responsible for killing tumours and viruses in the body.

The halogens bromide, chloride, and fluoride compete with iodine for the receptor binding sites in the thyroid, but instead of activating the receptors they build up in thyroid tissue and cause thyroid cell death and inflammation.

Vitamin D is what activates the receptor.

They found that short - chain fatty acids can bind to and activate a receptor molecule in the gut wall called Gpr41.

Endocannabinoids are naturally occurring substances in the brain that activate the receptor sites in the endocannabinoid system.

Beta - nano - crystals were used in vitro in cells to induce the NLRP3 pathway by activating the receptors second signal in the double signal pathway.

They also showed that activating the receptor with Δ7 - dafachronic acid could override the parasite's development and prevent S. stercoralis from becoming infectious.

Meanwhile, Granier became interested in adiponectin receptors after a Japanese group showed that a small molecule could activate the receptors for to increase insulin sensitivity in an obese mouse model.