Sentences with phrase «to carry the mutation»
The phrase "to carry the mutation" means that a person has a specific change or alteration in their genes that is different from most other people. Full definition
In families who carry the mutation, HD sometimes displays «anticipation» - a technical way of saying that disease onset can get earlier with each successive generation.
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The scientists also found that people carrying the mutation had the disease.
The researchers generated a genetically - engineered mouse carrying the mutation.
But in 80 % of these cases, neither parent carries the mutation.
Cells carrying the mutation didn't contract or move normally, the team found.
Remember that dogs that carry this mutation also carry other important good genes that we do not want to lose from the breed.
But all of the deaf children carried mutations on both copies of the gene.
Researchers initially planned to investigate the social behavior of mice that carried a mutation found in some people with autism.
At first, it seemed that nearly 16,000 individuals potentially carried the mutations.
However, the days when we watch the decline and death of loved ones carrying the mutation may be coming to an end.
The altered gene was inserted into mouse embryo cells which grew into male mice that carried the mutation in their sperm cells, enabling them to pass it on to the next generation.
Women who carry the mutations can pass them on to their children.
And will these turn out to be normal, for example an immature cell or even a skin stem cell, or are they abnormal cells carrying some mutation?
It's really another step in the direction of personalized medicine, since individuals carrying mutations of one of a variety of genes account for the largest group of infertile couples.»
«Clear» CMR dogs do not carry the mutation for the disorder.
«Even at that time, we knew that there were patients with similar symptoms that did not carry mutations in ASBT.
We discuss the radiological, cerebrospinal fluid, and clinical phenotype of patients carrying these mutations in the literature.
Tumours which carry mutations in KRAS genes (40 % of CCR) or BRAF genes (between 5 and 15 % of these types of cancers) are ineffectively treated and have poor prognosis.
Now a genetic test is available to identify dogs carrying the mutation causing progressive retinal atrophy in the two types of Irish Setters.
Using samples from the Dominantly Inherited Alzheimer Network (DIAN) study, the researchers found that people who carried the mutation responsible for this form of Alzheimer's also had altered levels of specific lipids in their blood plasma compared to the control group.
«Thus, nearly all gametes of an MCR individual carry the mutation in contrast to a typical mutant carrier in which only half of the reproductive cells are mutant.»
It also allows «lineage tracing,» showing when during brain development the mutations arise and how they spread through brain tissue as the mutated cells grow, replicate and migrate, carrying the mutation with them.
A dominant mutation is where one defective copy of a gene is enough to affect the individual, whereas a recessive mutation requires that both copies of the gene carry a mutation for the individual to be affected.
The handful of cases that still occur are most likely to affect non-Jews, families carrying mutations other than the distinctly Ashkenazi variants of the Tay - Sachs gene.
The cells had been genetically engineered to produce large amounts of APP, and also carried mutations linked to familial Alzheimer's.
Some humans naturally carry this mutation (known as CCR5Δ32) and they are resistant to HIV, because the mutation alters the CCR5 protein in a way that prevents the virus from entering the T cells it tries to infect.
In some families, the patient who was tested had normal sequences of BRCA1 and BRCA2, but her relatives with breast cancer carried a mutation in one of those genes.
An E. colona population carrying a mutation in the EPSPS gene endowing resistance to glyphosate, the most widely used non-selective herbicide, was recently identified in the Northern Sacramento Valley of California.
Using human embryonic stem cells (hESC) characterized as carrying mutations associated with adult - onset disease during pre-implantation genetic diagnosis, we investigated the influence of human HTT and of an adult - onset HD mutation on mitotic spindle orientation in human neural stem cells (NSCs) derived from hESCs.
The response rate was much higher in patients whose tumours carried mutations to genes involved in repairing DNA.
This was the data that provided evidence of «regions in the Altai Neanderthal genome that carry mutations observed in the Africans — but not in the Denisovan» or in Neanderthals found in European caves.
A genetic comparison with other Drosophila species showed that Drosophila sechellia carries a mutation in a gene called Catsup.
In mice carrying a mutation leading to premature aging, reprogramming of chemical marks in the genome, known as epigenetic marks, reduced many signs of aging in the mice and extended their lifespan on average from 18 weeks to 24.
Their results reveal that nearly a quarter of people who experienced SUDEP carried mutations linked to cardiac sudden death, suggesting that irregular heart rhythms may underlie a significant number of deaths in epilepsy.
Flies carrying the mutation maintained their visual response when fed with UDCA.
Previous studies have shown than those of African descent do not usually carry a mutation to the filaggrin gene (FLG) that has been associated with the risk of onset and persistence of AD in those of European and Asian ancestry.
Although stutterers that carry these mutations show no signs of mucolipidosis or other lysosome diseases, Drayna speculates that those drugs could be a useful therapy.
But these three variants are not the most common BRCA1 / BRCA2 mutations in the general population: No more than 0.1 percent of women with non-Ashkenazi ancestry carry the mutations.
Impulsivity played a pivotal role in the criminal behaviour of all 17 prisoners carrying the mutation, who were convicted of crimes ranging from murder and attempted murder to arson, battery and assault.
Icelandic scientists studying the DNA of 1,795 of their citizens unearthed a rare errant gene — only 1 in 10,000 people of European descent carry the mutation — that slows production of plaques in the brain.
One strain carrying a mutation named C580Y in the K13 gene is pushing out the others; in the process, it has acquired piperaquine resistance as well.
In patient - derived stem cells carrying a mutation predisposing them to frontotemporal dementia, which accounts for about half of dementia cases before the age of 60, the scientists found a targetable defect that prevents normal neurodevelopment.
They discovered non-human genomes carrying mutations that cause severe disease in humans, yet were benign in the animals.
He is currently examining the genomes of other animals to see if all large - brained mammals carry mutations in this gene.
«It is much more likely, that the first horses ever imported to Iceland already carried the mutation for alternative gaits.
In contrast, no European (Scandinavia included) or Asian horse of the same period carrying the mutation for the alternative gaits was found.
Tuberculosis (TB) strains in Russia carry mutations that not only make them resistant to antibiotics but also help them to spread more effectively, according to an analysis of 1,000 genomes from different TB isolates — one of the largest whole - genome study of a single bacterial species so far.