Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in human stem cells in the brain that
ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation.
The transit amplifying cell undergoes multiple rounds of symmetrical divisions before all of its daughter cells begin the process
of differentiating into neurons.
10/10/2007 Researchers Reveal Repressor Protein Blocks Neural Stem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells
from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... More...
Finally, we used this approach to encapsulate human Neural Stem Cells (hNSC) derived from human Induced Pluripotent Stem Cells (hIPSC), which were
further differentiated into neurons within the capsules with negligible loss of viability.
Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to
differentiate into neuron - like cells: treating them with exosomes.
A variety of agents have been shown to induce transplanted stem cells to
differentiate into neurons.
«I would bet these cells are getting into the maternal brain and are able to
differentiate into neurons.»
Already, we see that cells from people with bipolar disorder are different in how often they express certain genes, how
they differentiate into neurons, how they communicate, and how they respond to lithium,» says Sue O'Shea, Ph.D., the experienced U-M stem cell specialist who co-led the work.
Easily accessible from nasal biopsies, these cells — which belong to nerve tissues and can
differentiate into neurons — constitute an interesting model to identify the genes and proteins whose expression is deregulated in patients with ASD.
«In the mouse, as cells move away from the ventricles, they lose their ability to
differentiate into neurons,» Kriegstein explained.
This suggests that neural stem cells exposed to young systemic factors increase their ability to proliferate and
differentiate into neurons.