Sentences with phrase «to engineer cells»

By 130 days after receiving the infusion of engineered cells, tests revealed no evidence of disease.

With this approach, scientists can develop cell - based therapies that use engineered cells from the immune system as the «drug».

The authors say that successfully linking digital signals with engineered cells represents an important step toward translating similar cell - based therapies into the clinic.

While these kinds of engineered cells are not new, the new light - based technique promises much greater control over how much insulin is delivered at any given time.

Recently, scientists have engineered cells from a patient's own immune system to fight blood cancers.

Now that they've shown it's possible to encode and retrieve information sequentially in bacteria, Shipman hopes to create «molecular recorders» — genetically engineered cells with a time log of their activities.

This approach, combining precise genome editing in vitro with effective application of engineered cells in vivo, could provide «significant benefits for the treatment of many human diseases,» the authors note.

To add quantum dots to the curli fibers, the researchers engineered cells that produce curli fibers along with a different peptide tag, called SpyTag, which binds to quantum dots that are coated with SpyCatcher, a protein that is SpyTag's partner.

They also engineered the cells so they could communicate with each other and change the composition of the biofilm over time.

ReNeuron can generate large numbers of stable cell lines by engineering cells with a modified version of the gene c - myc.

To show that the technique works, Lu's team engineered cells that could monitor inflammation levels.

By pairing engineered cell lines containing disease - specific mutations with high throughput screening, we can investigate the role of given mutations in the biology of disease as well as identify potential druggable targets.

In Brooklyn, Modern Meadow, backed by $ 53 million from investors, creates «leather» using engineered cells rather than animal skins.

«Until now, quality control metrics for engineered cells have not gotten to the core defining features of a cell type.»

Patients who have enrolled in trials of this approach for acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and non-Hodgkin lymphoma (NHL) typically undergo lymphodepleting chemotherapy before receiving an infusion of their newly engineered cells.

LifeMap Discovery describes several transplantable tissue engineered cell sheets.

Each compact contains a flat, cushiony sponge containing tiny, precisely engineered cells of a BB - cream - like fluid.

There are some genetically engineered cells involved — along with near - infrared LEDs, subdermal hydrogel capsules, and electromagnetic field coils.

A signaling domain built into the CAR promotes rapid multiplication of the «hunter» cells, building an army of tumor - killing cells that tests reveal can grow to more than 10,000 new cells for each single engineered cell patients receive.

The Gigafactory is producing a Tesla / Panasonic designed and engineered cell called a «2170 cell,» as the diameter is 21 mm in x 70 mm in height.

Patients in the trial had been on ibrutinib for a minimum of six months and had not achieved a complete response when they received an infusion of engineered cells split over three consecutive days.

The patient received his first injection of 50 million of the genetically engineered cells on 27 January.

Once engineered cells are engrafted into laboratory mice, their GRN becomes even closer to that of the true target tissue, indicating that the body's own tissues contribute signals to enhance the performance of transplanted cells.

To gain insights into the complex mechanisms behind chemotaxis, the authors of the present study held a worldwide competition to «race» engineered cells through a microfluidic maze, up a chemical gradient to the finish line.

The first human trials testing genetically engineered cells missing the CCR5 receptor, begun in 2009, have been small but impressive.

Gauthier, Miller and co-workers engineered cells to express amino acid biosynthesis enzymes, which enabled cells to grow on their own supply of amino acids produced from supplemented precursors.

They further engineered the cells to express green fluorescent protein, enabling the cell to glow when it senses humid conditions.

Synthetic biologists engineer cells to store long - term information about their surroundings or activity

After outfitting the nanoparticles with their molecular assistants and engineering the cell membranes to receive the nanoparticles, the team applied a solution of nanoparticles to the cell cultures and switched on a magnetic field.

But in these experiments, the Penn scientists» engineered cells maintained their potency despite the presence of anti-Dsg3 antibodies that might have swarmed their artificial receptors.

With modifications, he notes, such a circuit could enable bacteria to kill themselves after they've completed their task, or after a certain number of generations — thus creating a safety device that would keep engineered cells from escaping into the environment.

In one case, the experts engineered cells from a rat's heart to contain the same mutation as their zebrafish had.

NY - ESO - 1 is a great target, and can be targeted with engineered T cells, by the way, using engineered cell receptors, which is another approach that looks very promising, but it's an intracellular protein and CAR T cells in general can't target that.

«The study in Nature shows that after a heart attach in mice, treatment with specially engineered cells can reduce this potentially lethal rhythm disturbance.

Today, we could be facing another paradigm shift with the use of injectable engineered cells as therapies: treatments that promise transformative, durable responses or even cures.

We propose a system of synthetic bio cementing where engineered cells, living within a soil matrix, respond to pore pressure changes in their environment when the soil is loaded, by synthesizing new material and strengthening the soil.

The new research, which studied the immortalization process using genome - engineered cells in culture and also tracked skin cells as they progressed from a mole into a malignant melanoma, suggests that telomerase plays a more complex role in cancer.

In addition to adding the genes for glucaric acid production, the researchers engineered each cell to produce a protein that synthesizes a small molecule called AHL.

The team also engineered the cells to deliver common cancer treatments to glioblastomas in mice.

When G - CSF activates its receptor, it ultimately activates proteins called STATs; the team engineered the cells to churn out the light - generating protein luciferase, which would be turned on by the STAT molecules.

«The global research community now has access to this information, which they can use to better understand these newly engineered cells and more quickly develop disease - specific cell line models that can be used to test new therapies and treatments for diseases.»

A tissue engineered cell - occlusive device for hard tissue regeneration — A preliminary report.

In one instance, he made the memory especially easy to read by engineering the cells to mutate an antibiotic resistance gene in response to light.

«That's one of the big goals: to engineer these cells from patients and then use them to study those patients» diseases.»

Created from engineered cell lines, cfDNA Reference Standards are available in both singleplex and multiplex format with cancer - relevant mutations.

They also genetically engineered cells to contain nonfunctional forms of NOD1.

In contrast to other studies that used HIV models with engineered cells, the team at GW conducted their research using the CD8 + T - cells of people living with HIV, in combination with LRAs to attack and kill the infected cells.

Ellington brushes aside those concerns, noting that the difficulty of engineering cells is beyond the scope of all would - be bioterrorists.

Eventually, the researchers think they many be able to engineer cells and tissues to grow organs that can repair or replace biological structures.