Sentences with phrase «to engineer the protein»
"To engineer the protein" means to manipulate the structure and properties of a protein through various processes in order to modify or create new functionalities. This involves altering the genetic code, adding or deleting specific amino acids, or changing the protein's overall structure to achieve desired outcomes. Full definition
Thus, the synthetic capabilities of enzymes set only a lower bound on the capabilities of engineered protein systems.
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Researchers have created engineered proteins that lowered body weight, bloodstream insulin, and cholesterol levels in obese mice, rats, and primates.
Similar to how biotech experts generate large quantities of genetically engineered proteins for drugs, this batch method could slash the cost of DNA synthesis to roughly $ 200 per gram, Dietz says.
But Halla's PowerPoint slides didn't mention that the Impossible Burger's key ingredient is a genetically engineered protein called soy leghemoglobin or «heme.»
In the new study, the MIT team deactivated Cas9's cutting ability and engineered the protein so that after binding to a target site, it recruits transcription factors (proteins that are required to turn genes on).
In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.
In contrast, the biologic approach injects a genetically engineered protein designed to knock out a tumor's ability to produce new blood vessels, thereby cutting off its capacity to grow.
«We can now begin to think about engineering proteins to do things that nothing else is capable of doing,» said senior study author Brian Kuhlman, PhD, professor of biochemistry and biophysics and member of the UNC Lineberger Comprehensive Cancer Center.
MIT's Shuguang Zhang biochemically engineered protein fragments so they self - assemble into nano - fibers to form a scaffold that fosters the growth of mammalian neurons, making it easier to study nerve cell functions.
Now head of her own lab at Stanford, Heilshorn engineers proteins to aid neural stem cells in healing injured brains and spines.
For the new imaging technique, the researchers engineered a protein to act as a sensor that latches onto serotonin and detaches at the moment of reuptake.
One little doughnut — a lab - engineered protein doughnut — could help researchers cure Alzheimer's and Parkinson's and restore a traumatized brain.
Organic origami: Gamers to engineer protein folds to fight disease University of Washington (U.W.) in Seattle biologist David Baker has decided to open part of his research up to anyone with a computer, an interest in protein science and some free time on their hands.
After establishing the effects of aging on astrocytes, the researchers took another step — evaluating the potential therapeutic effects of a specially engineered protein.
Other researchers have created such gels by engineering proteins that self - assemble into hydrogels, but this approach requires complex biochemical processes.
«Engineered protein enlisted to battle the MERS virus: Custom - engineered protein destroyed the deadly virus in the lab; could become a sweeping anti-viral in medicine and farming.»
Humans have found so many alternative uses for these molecules — as foods, industrial enzymes, anti-cancer drugs — that scientists are eager to better understand how to engineer protein variants designed for specific uses.
The OspC chimera in VANGUARD crLyme is a single engineered protein that contains antigenic material from seven different types of OspC
Talk of curing AIDS made front - page news last year, in part due to an astonishing new gene - editing technology: lab - engineered proteins called zinc finger nucleases.
According to Robyn O'Brien of AllergyKids, «Leading pediatric allergists and researchers have been funded by the agrichemical corporation responsible for engineering these proteins, chemicals and toxins into soy.»
September 21, 2016 Researchers describe key protein structure that could assist drug development A cross-lab team of scientists from UChicago describe the three - dimensional, atomic structure of an important cell receptor molecule linked to the development of several diseases, and engineer a protein molecule that turns off the receptor for treatment.
We will be developing tools to engineer proteins in living cells based on genetic code expansion and unnatural amino acid mutagenesis.
The team identifies where neurons are firing by injecting the brain with dyes or using genetically engineered proteins that bind to calcium molecules.
«So what we're able to do is to engineer these proteins so that they can bind to different genes of our choice,» says Gregory.
In a groundbreaking study recently published in the journal PLOS One, the scientists used a pair of engineered proteins to cut DNA in a site - specific manner to disrupt a targeted gene in the mosquito genome.
The company's studies, the FDA said, showed that even if any of the engineered proteins were transmitted to people «there was no convincing evidence» it would be toxic or trigger an allergic reaction.
On to the blocks were poured a mixture of recombinant human bone morphogenic protein (BMP) powder — a genetically engineered protein that causes cells to ossify or become bone — and liquid bone marrow containing stem cells.
Gundlach believes this tool may open a new window for understanding how cellular proteins process DNA, which could help genetically engineer proteins to perform novel jobs.
This is an illustration of how the engineered protein facilitates destruction of latently HIV - infected immune cells.
1) Protein and cells, from left to right: engineered protein with yellow - and - black CD3 - binding end and thick black HIV - binding end; latently HIV - infected helper T cell (blue); inactivated killer T cell (red).
The engineered protein has two ends: one activates T cells by binding to a surface molecule called the CD3 receptor, and the other — based on an antibody called VRC07 — powerfully binds to more than 90 percent of HIV strains.
A genetically engineered protein that heals fractured bones and damaged teeth is being tested in the US.
You engineer proteins to help stem cells regenerate neurons.
Moving to the Albert Einstein College of Medicine in New York City, Gravekamp teamed up with radiobiologist Ekaterina Dadachova and colleagues to combine modified Listeria with the radioactive compound rhenium - 188, which they attached to an engineered protein called a monoclonal antibody that sticks to the bacterium.
Those engineered proteins remained as the erythroblasts matured into red blood cells.
It contains an engineered protein that combines a protein fragment from the malaria parasite, Plasmodium falciparum, and a protein from the Hepatitis B virus that helps trigger a strong immune response.
But before these engineered proteins can be developed into medicine, researchers first must find a way to deliver them into the right part of the body.
In the April 13, 2007, issue of Science, the research team — led by James C. Lo, an MD, PhD student, in the laboratory of Yang - Xin Fu, MD, PhD, professor of pathology at the University of Chicago — suggest that an engineered protein could keep mice, and possibly humans, from developing high cholesterol and triglyceride levels, a key risk factor for coronary heart disease.
However, if researchers blocked the LIGHT signaling, using an engineered protein (LTβR - Ig), lipid levels were lowered again.
Ancient proteins may offer clues on how to engineer proteins that can withstand the high temperatures required in industrial applications, according to new research published in the Proceedings of the National Academy of Sciences.
One strategy scientists have developed is to engineer proteins to serve as tiny research tools that can be inserted into the cell.
The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin — expressed on the surface of such tumors as mesothelioma, ovarian cancer and pancreatic cancer — to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells.
The Meiler laboratory develops technologies to engineer protein, for example through assembly of large protein scaffolds from fragments (Fortenberry, C.; et al.; «Exploring symmetry as an avenue to the computational design of large protein domains»; JACS 2011; 133; 18026 & Eisenbeis, S.; et al.; «Potential of Fragment Recombination for Rational Design of Proteins»; JACS 2012; 134; 4019).
As noted above, existing cancer vaccines that use dendritic cells require extracting cells from a patient's blood, treating them with an engineered protein or nucleic acid that combines tumor antigens with immune - stimulating molecules, and returning the activated dendritic cells to the patient.