Sentences with phrase «to extend survival»
The combination was significantly toxic to pancreatic cancer cells and disrupted tumor growth and extended survival in several types of advanced pancreatic cancer mouse models.
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Fortunately, many types of heart disease can be managed medically, extending survival times and improving the quality of life in the meantime.
There is no cure, and only one drug modestly extends survival by only a few months.
A one - time intravenous infusion of the high dose of gene therapy extended the survival of patients with spinal muscular atrophy type 1 (SMA1) in a Phase 1 clinical trial, according to a study published in the New England Journal of Medicine.
In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.
«Drug extends survival of patients with metastatic colorectal cancer.»
By performing experiments in petri dishes and with mice, they found that panobinostat, a drug designed to change the way cells regulate genes, may be effective at inhibiting DIPG growth and extending survival rates.
If positive, this portable intraoperative Raman Spectroscopy probe will improve brain cancer surgeries and in turn extend survival times for brain cancer patients.
The drugs did not extend survival of mice with a different medulloblastoma subtype.
For example, placing lab animals on a meager diet that replicates food scarcity in the wild extends survival in many species.
Small molecule MYC inhibitor conjugated to integrin - targeted nanoparticles extends survival in a mouse model of disseminated multiple myeloma.
«Drug combination extends survival by more than a year in metastatic prostate cancer.»
Hopefully that will approximate cures or will greatly extend the survival of ovarian cancer patients.
More importantly, none of the previous studies has demonstrated that HDAC inhibitors can extend survival when delivered after symptoms appeared.
Lead author Professor Ledermann, professor of medical oncology at the UCL Cancer Institute and a Cancer Research UK grantee, said: «A well - tolerated anti-tumour agent that could be used for months or perhaps years as maintenance therapy after standard chemotherapy could be a big step forward and ultimately extend survival.
The immune - based treatment Yervoy (ipilimumab) was the first drug shown to extend survival among patients with advanced melanoma and was approved by the FDA in 2011.
«Immunotherapy is generally nontoxic, so this vaccine has the potential of safely extending survival and reducing the effects of these tumors, possibly even cutting the risk of recurrence.
Provenge, made by the biotech company Dendreon, is one of a wave of extraordinarily expensive new cancer therapies that, in clinical trials, extended survival only modestly.
While diet isn't considered a way to manage the disease itself, it is used to extend survival times and to improve a dogs quality of life, regardless of whether they are undergoing treatment.
Following the US Food and Drug Administration (FDA) approval of ipilimumab the following year, approvals of other targeted therapies (against BRAF and MEK), and most recently, approvals and extended indications for other checkpoint inhibitors, especially the programmed death 1 (PD - 1) / programmed death ligand 1 (PD - L1) inhibitors, have constituted a revolution characterized by higher response rates and the potential for extended survival.
New data released earlier this week from another pivotal phase III clinical trial (study CA184 - 024) show the antibody also extends survival in patients with metastatic melanoma who have not received prior therapy.
The drug's manufacturer, Roche, said trials in these patients have shown that giving pertuzumab in combination with the drugs trastuzumab (Herceptin) and docetaxel could extend survival by nearly 16 months compared to standard treatment.
UC San Diego surgeons are awarded a federal grant to study how to extend survival of lung transplant recipients.
«We also confirmed a role in PDAC tumor maintenance as inhibition of PRMT1 in patient - derived mouse models significantly inhibited tumor growth and extended survival,» said Giuliani.
In a new publication that appears in Human Molecular Genetics, the laboratory of Christine DiDonato, PhD reports on their pharmacological characterization of the drug RG3039, demonstrating that it can extend survival and improve function in two spinal muscular atrophy (SMA) mouse models.
«Our current treatment helps the body create a backup mechanism to combat the disease and extends survival in mice with SMA from just 13 days to a little over five months after only one injection at birth,» Lorson said.
One, in which Dr. Weiss was the senior author, highlighted the extended survival of metastatic small cell lung cancer (SCLC) patients who received statins.
A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).
However, this is the first time these biodegradable nanoparticles have effectively killed brain cancer cells and extended survival in animals.
When the scientists placed DIPG cells in the pons area of mice they found that systemic injections of panobinostat inhibited DIPG growth and extended survival.
«Rare mutation may extend survival in lung cancer patients with brain metastases.»
«Our work has shown that we can extend survival of the mice.»
George Fuhrman, a surgeon at the University of Texas MD Anderson Cancer Center in Houston, said: «What we hope for is to extend the survival of patients with liver cancer, at least in the short term, and improve the quality of their life.»
«After more than a decade in the lab trying to assess how methylnaltrexone affects cancer, we have the first evidence that it can decrease tumor growth and extend survival in patients who respond to the drug.»
«Drug for digestive problem can extend survival for many advanced cancer patients.»
The agency interrupted a Phase III trial of 675 patients with advanced melanoma to approve the drug when it became clear it was extending survival.
We therefore believe that the balance of stresses between the particles and the protein is important for the extended survival of teeth in the mouth, Charite scientist Jean - Baptiste Forien says.
Ipilimumab was the first drug ever shown to extend the survival of patients with metastatic melanoma.
But as fewer and fewer women were diagnosed with large breast tumors, pre-op chemo began to be used in patients with smaller cancers, too, in the hope that it would extend survival.
Extended survival and prognostic factors for patients with ALK - rearranged non-small-cell lung cancer and brain metastasis.
«If we could develop drugs that boost Nrf2 production in the neurons most susceptible to Huntington's, we might extend their survival, thereby staving off the worst effects of the disease,» said former Gladstone Postdoctoral Fellow Andrey Tsvetkov, PhD, the study's lead author.
Dr. Sadelain's work has focused on developing novel strategies to extend survival of CAR T cells in the body and enable T cells with increased potency to overcome the resistance imposed by tumor and other cells in the tumor microenvironment.
Although such efforts have extended survival, most often the prognosis remains exceedingly poor due to the persistence (or progression) of the pathologic deposits.
The lead compounds have shown the ability to extend survival in a mouse model of SMA.
October 27, 2015 Drug for digestive problem can extend survival for many advanced cancer patients Patients with advanced cancers who took a drug designed to relieve constipation caused by pain killers lived longer and had fewer reports of tumor progression than cancer patients who did not receive the drug, according to results presented October 27 at the 2015 meeting of the American Society of Anesthesiologists in San Diego.
In mouse models of both tumors, treatment with the fusion protein significantly slowed tumor growth and extended survival, probably through the activity of cytotoxic CD8 T cells.