The phrase
"to identify these compounds" means to figure out or determine what these substances are.
Full definition
The sheer quantity and variety of
identified compounds with documented health benefits qualifies maple syrup as the next champion food.
Given that compounds such as NBOMes are modified with the goal of avoiding detection by routine techniques, forensic laboratories are faced with the challenge
of identifying these compounds quickly and accurately.
After a rigorous selection process, Dr. Kim and her team received an additional grant to conduct a clinical trial investigating the effect of the
newly identified compound in client - owned cats with FIP.
Working with Ye, postdoctoral fellow Sung - Wuk Jang
identified a compound called 7,8 - dihydroxyflavone that can duplicate BDNFâ $ ™ s effects on neurons and can protect them against damage in animal models of seizure, stroke and Parkinsonâ $ ™ s disease.
«Metastatic pancreatic cancer «reprogrammed» for malignancy:
Study identifies compound that could lead to treatments for aggressive metastatic disease.»
Structure - based drug design, in which the physical structure of a targeted protein is used to
help identify compounds that will interact with it, has already been used to generate therapeutic agents for a number of infectious and metabolic diseases.
Even so, the identification of an LF target molecule represents the first step
toward identifying compounds that can counteract the toxin — which could be a boon if the anthrax bacillus were to be used in a terrorist attack.
Investigators must
precisely identify the compound and show that — unlike lighter fluid in a convenience store — it would not normally be found at the scene.
Though no approved FDA therapies exist specifically for NPC, several years ago two labs, headed by John Dietschy of the University of Texas Southwestern Medical Center and Steven Walkley of Einstein,
independently identified a compound with promise.
In an effort to identify mutations that would render dengue virus insensitive to AM404 —
thereby identifying the compound's target, the researchers tried to generate resistance mutations by culturing the virus in the presence of AM404.
Besides recognizing odors from their caterpillar hosts, wasps also learn to
identify compounds released by the plant on which the caterpillars feed
This requires the intervention of sophisticated robotic technology to produce the required quantities of cells on one hand, to practice drug tests under conditions to
identify the compound effective to thousands of thousands of others, on the other hand.
The prototype of such bis - macrocycles, plerixafor, was used in a recent study as a starting point for structural modification, in order to
identify compounds endowed with a similar antiviral activity and improved pharmacokinetic properties [94].
To create the Hub, the researchers — led by Broad chief scientific officer Todd Golub and postdoctoral scholar Steven Corsello, an oncologist at Dana - Farber Cancer Institute — scoured public and proprietary databases to
identify compounds representing a diverse range of targets and chemical structures.
Scientists have
previously identified compounds that can reactivate HIV by activating transcription, but these compounds are not very effective, in part because of the noisiness of HIV transcription.
Emphasis will be placed on proper aseptic technique, compounding non-sterile products,
identifying compounding supplies, handling of chemotherapy and biological agents, compounding of total parenteral nutrition (TPNs), and interpreting and labeling of compounded medication orders.
performed basic chemistry procedures such as Fractional and simple and steam distillation,
identifying compounds using Thin Layer Chromatography.
Analytical chemists, for example, conducted tests that
identified compounds in charred insulation, while chemists and toxicologists determined the harmful properties of burned insulation.
Although the new research looks «promising,» the
newly identified compounds have not been tested outside of the lab, says James Logan, scientific director of the Arthropod Control Product Test Center at the London School of Hygiene and Tropical Medicine, who did not contribute to the study.
The researchers are continuing their study of bacterial viruses in the hope
of identifying compounds and processes that facilitate improved treatment of antibiotic - resistant bacteria using yet uncharacterized bacterial viruses» proteins.
«Our goal is to
identify compounds with medicinal, environmental and other uses that can be renewably produced in substantial amounts at a reasonable cost.»
The Houston Methodist researchers culled through thousands of existing drugs to see if they could
identify a compound that would prevent cancer cells from spreading, or metastasizing.
Seeking a more viable path forward, Annika Axelsson and colleagues used a computational approach to
identify compounds that might counter the disease - associated gene expression changes associated with type 2 diabetes.
It identifies compounds of Legionella in the urine of patients.
Researchers at Johns Hopkins have unraveled the molecular foundations of cocaine's effects on the brain, and
identified a compound that blocks cravings for the drug in cocaine - addicted mice.
We set out to
identify these compounds.»
Sutcliffe says that law - enforcement agencies and academics should be proactive, and look to
identify the compounds that such companies are likely to turn to next, rather that waiting for a new chemical to appear on the market.
The researchers have
identified a compound that reverses the reprogramming and prevents tumor formation in model systems.
It is the goal of many pharmaceutical and food manufacturers to
identify compounds that either block or alter bitter perception, to create a more palatable product.
In the future, Dong hopes to
identify a compound that can block the G protein - coupled receptor on vagus nerves as a means of stopping airway «itch» and curbing asthma.
UCLA chemists and molecular biologists have for the first time used a «structure - based» approach to drug design to
identify compounds with the potential to delay or treat Alzheimer's disease, and possibly Parkinson's, Lou Gehrig's disease and other degenerative disorders.
For instance, researchers used virtual screening to
identify compounds that target the gene for PFKFB3, an enzyme that helps regulate the metabolism of cancer cells.
The research team is now studying the effects of some of
the identified compounds in mice experimentally infected with MERS - CoV.
«One of the goals in this field has been to
identify compounds that elicit a more biased or selective response from iNKT cells, and we were able to incorporate features in AH10 - 7 that did that,» says Howell, who has been studying the role of glycolipids in modulating the human immune system for more than 20 years.
Now, researchers at Washington University School of Medicine in St. Louis have
identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer's protein amyloid beta.
They also have
identified a compound that targets the «on» switch for cancer - promoting genes, which resulted in shrinking tumor size and increased survival in an animal model of DIPG.
Their assay was designed to
identify compounds that blocked the ability of the Ebola virus to enter and infect human cells by at least 50 percent.
With that idea in mind, Neuralstem, in Rockville, Md., has
identified a compound that is particularly effective at prompting neurogenesis.
Hany Dweck then performed electrophysiological measurements to test
all identified compounds with respect to their ability to activate the pheromone - specific neuron.