«We show that these endosomal inhibitors, currently used in, for example, the prevention and treatment of malaria can be used to
prevent metastasis of colorectal cancer, without increasing the toxicity of standard treatments.
«Most research has focused on how
p53 prevents metastasis by regulating epithelial - to - mesenchymal transitions,» a biological process by which cells gain migratory and invasive properties.
«Scientists combine a peptide with a nano cancer drug formulation to improve treatment effectiveness and
prevent metastasis in pancreatic cancer.»
They then used a combination of chemotherapy and gene therapy to target the cancer cells directly in order to inhibit growth and
prevent metastasis while sparing normal healthy cells.
Researchers at EPFL have now found a way to reclaim the corrupted immune cells, turn them into signals for the immune system to attack the tumor, and
even prevent metastasis.
If his findings are corroborated, it would be an important discovery that could expand the use of CDK 4/6 inhibitors to
prevent the metastasis of many other cancers that exhibit a high level of the SNAIL protein.
According to Irving Weissman of the Stanford University School of Medicine in Palo Alto, California: «We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and
prevent metastasis.»
For example, inhibiting the binding of beta - arrestin - 1 to E2F1 would be a potential avenue to
prevent metastasis.
«What we may be looking at,» he adds, «is a future way to
prevent metastasis to many organs simultaneously» using drugs that make tumor cells let go of the blood vessels they cling to.
«Targeting this protein might
prevent metastasis and recurrence of breast cancer,» Dr. Paul said.
So making cells in the primary tumor softer might be a way to
prevent metastasis,» he said.
Researchers saw that injecting the miR - 34a mimic in mice could
prevent the metastasis of breast and skin cancer cells specifically to bone, mainly by disarming the metastatic niche in bone.
The finding opens the door to drug treatments that
prevent metastasis.
The discovery could help with future development of novel treatments to
prevent metastasis and secondary tumours.
«The implication is, if there's a switch, maybe there's a drug with which we can block this switch and maybe we can
prevent metastasis or even cure metastatic prostate cancer,» he added.
«This finding also opens up the possibility that when treating cancer, we should test whether increasing oxidative stress through the use of pro-oxidants would
prevent metastasis,» said Dr. Morrison.
So Meadows takes on the challenge of finding blocking mechanisms to limit or
prevent metastasis, the spreading of cancer through the body from the point of origin.
«The implication is, if there's a switch, maybe there's a drug with which we can block this switch and maybe we can
prevent metastasis or even cure metastatic prostate cancer.»
While they are all nutritious in themselves, broccoli is a veggie that's always in my fridge these days given its reported ability to
prevent metastasis and suppress tumours.
If your dog suffers from foot pad or nail bed melanoma, leg amputation might
prevent metastasis.
Still in the research stages, gene therapies include development of medicines to be injected into the tumor to jump start the immune system into battling the cancer and
preventing metastasis.