Sentences with phrase «to promote metastasis»

One reason to question the findings, however, is that if pre-op chemo promotes metastasis in some patients, that might be expected to have shown up in studies of the therapy.

We report that ABL kinases promoted metastasis of breast cancer cells to bone by regulating the crosstalk between tumor cells and the bone microenvironment.

Dr. Julie Gralow, a medical oncologist at the University of Washington, said that if pre-op chemo promoted metastasis, that should have shown up in studies that compared it to post-op chemo, but for the most part it hasn't.

So what to do with this information next «is a dilemma,» Zhang says, because so far there are no data suggesting that the drugs promote metastasis in people with both diabetes and cancer.

On - going studies are aimed at examining a hypothesis that A-to-I editing of miR - BART6 RNAs antagonizes the EBV viral strategy of manipulating the host cell RNAi mechanism and consequently promoting metastasis of certain cancers such as breast cancer.

Two other neoadjuvants, doxorubicin and cyclophosphamide, also promoted metastasis by altering the tumor microenvironment.

To evaluate whether ABL1 and ABL2 are individually responsible for promoting metastasis, we used specific shRNAs to silence either ABL1 or ABL2 in breast cancer cells.

Similar to IL - 6 and MMP1, TNC is abundant in some breast tumors and promotes metastasis in mouse models (49).

Paolo E. Porporato, a post-doctoral researcher, and other young researchers in Professor Pierre Sonveaux's team, examined the molecular mechanism responsible for the mitochondria's ability to promote metastasis.

«However, in recent years it has become evident that inflammation is a factor that can promote metastasis and that anti-inflammatory drugs may have a certain inhibitory effect on the spread of cancer.»

«Our findings underline the importance of RUNX2 in promoting metastasis and suggest that drugs that inhibit its function would prevent or treat prostate cancer metastasis,» notes Dr. Gelman.

These results not only show promise on a new targeted therapy to treat this malignancy, as PI3K inhibitors are already used in the clinical practice, but also unravel a new function of the PI3K kinase in cancer biology through its role in promoting metastasis.

While tumors of the omentum are uncommon, the circulating fluids bring back cancer cells into the milky spots, where they get trapped like grass in a pool filter, promoting metastasis.

The team also found that these genes had different functions in promoting metastasis: One group encouraged growth of tumor cells in both breast and lungs, whereas the other only helped the new tumor thrive in the lungs.

By contrast, the study suggests that Exo - L may promote metastasis to lymph nodes, while Exo - S may support distant metastasis.

But pre-op chemo can, instead, promote metastasis, scientists concluded from experiments in lab mice and human tissue, published in Science Translational Medicine.

On a brighter note, not all breast cancer patients have the kind of tumor microenvironment in which pre-op chemo can promote metastasis.

Murphy and colleagues evaluated the impact of one of these variants, called Pro72Arg, on the ability of p53 mutations to promote metastasis.

The recommendation to eat some carbohydrates, plus my statement that it was possible for cancer patients to develop a «glucose deficiency» which might promote metastasis and the cancer phenotype, seems to have stirred a bit of a fuss.

With curcumin, the tumor cells synthesize smaller quantities of cytokines that promote metastasis.

Inflammatory conditions created by cells of the innate immune system, including natural killer and dendritic cells, appear to promote metastasis in inflammatory breast cancer.