His portrait of John E. Sulston, who won the Nobel prize in 2002
for sequencing the human genome on the Human Genome Project, [18] is in the National Portrait Gallery.
The man who
first sequenced the human genome and designed the first synthetic cell explains why simple algae — and some genetic engineering — may hold the key to our future
The move comes in response to the announcement earlier this week of a new U.S. company, launched by sequencing - machine manufacturer Perkin - Elmer and J. Craig Venter of The Institute for Genomic Research, that plans a brute - force approach to
sequencing the human genome within 3 years (ScienceNOW, 12 May).
Even with most of the 3 billion DNA bases lined up in the right order, there was still much that researchers couldn't see in the
newly sequenced human genome in 2001.
The goal is to show that it is possible to
accurately sequence human genomes inexpensively, with the hope that collecting such data will eventually become routine in the clinic.
In the past decade innovation has taken researchers
from sequencing the human genome, in 2001, to synthetically creating a bacteriophage in 2003, to just three years ago, turning one type of bacteria into another by genome transplantation.
The biggest expense in
sequencing a human genome now is the cost of storing it, says Scott Kahn, chief information officer of Illumina, a San Diego biotech company specializing in high - throughput sequencing.
In the same way that the fly genome paved the way for larger projects,
including sequencing the human genome, FlyEM may ultimately contribute to our understanding of the human brain by establishing a fly «connectome» — a map that shows how all neurons in the fly brain are connected to each other.
Montgomery, S.B., Lappalainen, T., Gutierrez - Arcelus, M. & Dermitzakis, E.T. Rare and common regulatory variation in population -
scale sequenced human genomes.
An Animated History of Reproduction Part cloning experiment, part documentary, Stories from the Genome follows an unnamed CEO - geneticist whose
company sequenced the Human Genome in 2003 — a genome that secretly was his own.
The development of molecular genetic methodology started to shift the focus of study towards locating and identifying specific genes underlying genetic effects evident in twin and adoptive studies, even
before sequencing the human genome was completed.
As the cost
of sequencing the human genome has plummeted in recent years, many medical researchers have touted the potential of personalized medicine — exotic therapies and synthetic drugs that are tailored to our individual genetic makeup.
«Understanding the microbiome, just
as sequencing the human genome, is one part of the puzzle on human health and disease,» said study co-author J. Craig Venter, PhD, co-founder and executive chairman of Human Longevity, Inc. «New technologies, such as machine learning, are allowing for tremendous advances to interpret these data.»
IN THE DECADE since researchers
first sequenced the human genome, obvious links between the genes and individual diseases have been slow to appear [see «Revolution Postponed,» by Stephen S. Hall; Scientific American, October].
Venter, who is one of the first people to
sequence the human genome, co-founded the company in effort to discover early genetic markers for a variety of disorders.
Venter explained that when he first
sequenced the human genome 15 years ago, there was nothing for him to compare it to.
Revolutionary breakthroughs have been made over the past few years in
sequencing the human genome, leading to new treatments for cancer and other diseases.
The, members of the workshop believe that knowledge gained from mapping and
sequencing the human genome can have great benefit for human health and well being.
Craig Venter made history in June 2000 when he and Francis Collins, leading different research teams, jointly announced the results of their projects to
sequence the human genome.
«
Sequencing the human genome, device miniaturization, and the advent of combination devices have shifted the focus from engineering to the life sciences in the device industry,» adds Jules Mitchel, president of Target Health Inc. in New York City, a company that conducts clinical trials for MD&D companies.
Not only has the science changed (who would have thought 5 years ago that we'd have
a sequenced human genome?)
Venter — who likes being compared to Galileo — led one of the teams that
sequenced the human genome in the late 1990s.
Yet a third player in the emerging algae fuel market is Synthetic Genomics, the brainchild of genomics guru Craig Venter, who beat the U.S. government in
sequencing the human genome and at a fraction of the cost.
He proposed creating an institute to
sequence the human genome.
Sequencing the human genome cost roughly $ 500 million, and essentially all that scientists had to show for the money was a long string of letters that make up human DNA.
[Haemophilus influenzae is a bacterium, the first organism to have its entire genome sequenced, which Venter completed in 1995; Drosophila is the common fruit fly, whose genome Venter sequenced as a warm - up to
sequencing the human genome.]
In 1998, a mad scramble began after Celera Genomics in Rockville, Maryland, boasted that it would be the first to
sequence the human genome.
The $ 6.5 - million - a-year Genome Data Base (GDB)-- funded mainly (80 %) by the Department of Energy (DOE)-- was initially conceived as a resource for
sequencing the human genome.
A new type of technology has
sequenced a human genome in a month and for less than $ 50,000 worth of reagents, according to a report today in Nature Biotechnology.
When researchers decided to
sequence the human genome in the late 1990s, they were focused on finding those traditional genes so as to identify all the proteins necessary for life.
The $ 10 million Archon X Prize will reward any group or person who can
sequence the human genome in 10 days or less for no more than $ 10,000 per genome.
Herceptin and the her2 test arrived at a heady moment for biology, when the race to
sequence the human genome was close to completion and optimism ran high that more biomarker - targeted cancer drugs were close at hand.
An image of an electrocardiogram alludes to the 1950s invention of the pacemaker, and a twist of DNA represents Canada's role in
sequencing the human genome.
Another attendee was Craig Venter, who led a private effort to
sequence the human genome in the late 1990s that competed with a public effort led by Collins.