Sentences with phrase «to target this pathway»
The phrase "to target this pathway" means focusing on a specific process or route in order to affect or control it. Full definition
So, the difficulty lies in targeting the pathway without causing unwanted side effects.
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A clinical benefit or improved patient outcome of three to eight months was seen in seven of the 19 patients (37 percent) who received drugs targeting this pathway.
«Knowing that these metabolic changes actually drive cancer growth gives us an important rationale to target their pathways as therapy,» he says.
Current therapies for high - risk B - ALL are aimed at targeting the pathways that promote rather than those that fight leukemia.
Surprisingly, the mutant parasites can not be killed by the anti-malarial drug chloroquine, which interferes with hemozoin formation, but yet, remain sensitive to the drug artesunate which targets another pathway of hemoglobin digestion.
«Lastly, our data raise the possibility of therapeutic strategies to overcome chemoresistance by targeting pathways identified in this study,» said Navin.
This uncovers the potential for a diabetes drug under development, which targets this pathway, to be repositioned to aid organ transplantation.
Palovarotene is a class of drug that selectively targets a pathway involved in cartilage formation.
Because SUMOylation affects a variety of molecules, Bernstock believes his group's approach could inspire similar attempts to treat neurological conditions by targeting pathways with wide - ranging effects.
The team is now exploring if targeting these pathways, combined with immunotherapy, can increase the proportion of patients that might respond to such drugs.
Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.
«The fact that the vitamin B12 - taurine - bone pathway affects only bone formation and appears to play the same role in mice and human beings raises the prospect that targeting this pathway through pharmacological means could be a novel approach toward an anabolic treatment of osteoporosis.»
A drug treatment targeting this pathway might be able to get a much greater effect.»
«Pharmacologically targeting these pathways could lead to the development of new drugs to treat communication deficits in humans.»
«Once we can understand what the key pathways are that cause this variability, we can start to think about targeting those pathways, to combat alternate outcomes in cancer treatment, for example.»
In the study, scientists discovered for the first time that antidepressant drugs such as Prozac and tricyclics target a pathway in the hippocampus called the BMP signaling pathway.
If we can therapeutically target that pathway, we may be able to have an impact on this very difficult - to - treat disease,» says the study's senior investigator, Derek Radisky, Ph.D., a researcher with the Mayo Clinic Cancer Center in Jacksonville, Fla..
«Drugs of abuse target the pathways of the pleasure centers very effectively,» said first author Gabriel Bossé, Ph.D., a postdoctoral researcher in Randall Peterson's lab at U of U Health.
«These findings suggest that new therapeutics targeting this pathway could treat a broad range of neurodegenerative and psychiatric disorders,» McAllister says.
«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»
Enzalutamide targets a pathway inside prostate cancer cells that was discovered as a result of over a decade of painstaking laboratory and clinical science.
This suggests that the WNT pathway may be responsible for the observed structural disruption in the DISC1 - mutants, and could be a potential target pathway for future therapies.
Additional inhibitors targeting this pathway are under development by multiple pharmaceutical companies for this genetic disease and other conditions, including diabetic macular edema.
New drugs targeting these pathways may be useful against a variety of different cancers.
«Takinib is unique for its ability to selectively target a pathway, since many inhibitors shut everything down,» Derbyshire said.
«Blocking known cancer driver unexpectedly reveals a new tumor - promoting pathway: Targeting both pathways with drug inhibitors more effective in stopping colorectal cancer growth.»
Research in the Kaeberlein Lab is focused on developing therapies for age - associated diseases by targeting the pathways that regulate aging.
One approach to treating cancer, therefore, is targeting the pathways that cancer cells have adapted to meet these energy needs, thus «starving» the cancer.
For one thing, if an investigator has a hypothesis that a specific CNS system may be involved in a neurobiological disease and designs a drug to target those pathways, then it is essential to ensure that sufficient drug reaches its intended sites of action to adequately test the treatment concept.
The work suggests that changing levels of the PIAS1 protein and targeting this pathway could have a benefit to disease.
They are also looking into ways that clinicians may be able to target the pathways that confer the most benefits.
«You could imagine that you could develop novel antibiotics that could target this pathway,» Rapoport said.»
This webinar is the first in a series (see Part 2 here) focusing on the pathways that allow for cancer development and progression, the emerging research in identifying and targeting these pathways, and the innovations in the development of cancer treatment options.
This webinar is the third in a series focusing on the cancer pathways that support tumor development, the emerging research in identifying and targeting these pathways, and innovations in the development of increasingly effective cancer therapy options.
This webinar is the second in a series (see Part 1 here) focusing on the cancer pathways that support tumor development, the emerging research in identifying and targeting these pathways, and innovations in the development of increasingly effective cancer therapy options.
Researchers are now trying to target these pathways to treat immune diseases.
«Our aim was to identify what changes in a mosquito during infection, so that we can target those pathways and block them to prevent transmission of these mosquito - borne viruses,» said Rushika Perera, assistant professor in the Department of Microbiology, Immunology, and Pathology at CSU.
We believe cancer drugs targeting this pathway could be a viable option for future immunotherapies.»
«This work is a critical step forward in decoding how stress makes us sick and provides a new target pathway in the mast cell for therapies to improve the quality of life of people suffering from common stress - related diseases.»
A variety of drugs that target this pathway are currently undergoing trials for a range of cancers, and we hope to adapt these to target autoimmune conditions in future.
«If you target this pathway, you have a really good chance of preserving the functional aspects of neurons after a variety of types of trauma or injury,» said senior author Marc Freeman, Ph.D., director of the Vollum Institute at OHSU.
Because myostatin normally acts to limit muscle growth, there has been considerable interest in targeting this pathway to attempt to enhance muscle growth in human patients with muscle wasting and muscle degenerative diseases.
Since stem cells are also critical for regeneration in the intestine, therapies that target these pathways may further help to design new drugs that reduce side effects associated with chemotherapy, radiotherapy or other causes of intestinal damage.
Yeast chemical genetics identified the targeted pathway, conserved from yeast to human cells, of one such molecule.
Second, even if these pathways are important, the other effects of drugs targeting these pathways may make it difficult to use them in Huntington's disease.
«We want to see if these tumors might be selectively sensitive to therapies that target the pathways that are disrupted as a result of these fusion genes,» Baker said.
This discovery has inspired the development of approaches to target this pathway in patients being treated with ipilimumab.
Drugs that target these pathways may have broad utility against a wide range of aneuploid cancers, while exhibiting minimal toxicity in euploid tissue.