Sentences with phrase «to target this receptor»

By understanding how the body's natural hormones operate, they aim to develop synthetic compounds to target these receptors in order to create drugs to treat diseases.

These tiny compounds easily pass through different body systems to target receptor proteins studded in the membranes of our cells.

The trouble is that drugs targeting these receptors can have bad side effects.

«In the near future, we'll likely see more medications specifically targeting receptors on cells involved in allergic reactions, such as tyrosine kinase inhibitors (mast cells), for dermatologic use.»

This could lead to the use of targeted receptor therapy in the treatment of TNBC and, in turn, to better patient outcomes.

We describe ligand - mediated receptor assembly as an early event in receptor signaling and its application to the screening of chemicals for interaction with targeted receptors.

By specifically targeting the receptor subtypes and monitoring their downstream effects, Wang hopes to pinpoint each one's function.

Like many drugs, beta blockers target receptors embedded in the surface of cells.

OCA targets the receptors in the ileum that stimulate the production of FGF19.

Inglis attributes this success to the fact that the bacteriocin targets a receptor on the bacteria's cell surface that is essential to its survival.

Using newly discovered information, the researchers made significant advances in developing a family of drug candidates that target a receptor known as peroxisome proliferator - activated receptors gamma (PPARγ), a key regulator of stem cells controlling bone formation and bone resorption and a master regulator of fat.

The new findings that coupling mechanisms and the receptor are important for keeping the balance may explain why common anti-tumor treatments targeting the receptor have heavy side effects for the skin.

When an LDL particle (carrying cholesterol) binds to the LDLR, the particle is trafficked into the hepatocyte, and PCSK9 targets the receptor for lysosomal degradation.

In the latter area, more than 50 % of drug discovery screens use cell ‑ based assays, predominantly targeting receptors and ion channels using fluorescence ‑ based measurements, in either or both high throughput and high ‑ content formats (1).

The finding had therapeutic implications, since targeting this receptor - hormone interaction could be used for either contraceptive or fertility treatments.

Not only is this a novel way to study basic biological mechanisms of these commonly targeted receptors inside the brain and individual neurons, but it's also a tool scientists can use to study specific effects of drugs in various regions of the brain.

Its small molecule drug conjugates are actively target receptors that are over-expressed on diseased cells.

On their surface, the liposomes are studded with proteins that target receptors on glioma cells.

Experts at the University of Pennsylvania eventually identified the mysterious antibody as a type that targets receptors in the central nervous system that are involved in memory and neuron function.

Since all antibodies of the same family share a common region, a simple alteration of the antibody results in a novel delivery carrier that adjusts to the target receptor of choice.

In principle, he says, a drug developed to target this receptor could stimulate the growth of new spines, with possible implications for altering libido in humans.

For the investigation at the X-ray laser, the researchers grew tiny crystals of the serotonin receptor with the molecule ergotamine attached, which is a migraine drug that targets this receptor.

«The next step in this process is to come up with a drug that can target this receptor,» says Kirill Martemyanov, PhD, co-chair of the TSRI Department of Neuroscience and senior author of the new study, published recently in the journal eLife.

Importantly, this suggests that it may be possible to improve memory and treat Alzheimer's disease using a drug that targets these receptors.

«If further studies validate that these processes are critical in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or treatment of breast cancers.»

Targeting receptor 2, Dawson identified a chemical that reduced a mouse's startle response — a measure of anxiety — without impairing its ability to balance atop a rotating rod.

Furthermore, targeting this receptor with an available drug called CTLA4 - Ig, or abatacept, helped to maintain kidney function in mice with diabetic nephropathy.

Since adiponectin binds to two receptors, AdipoR1 and AdipoR2, Yokoyama, who leads the RIKEN Structural Biology Laboratory, and his team surmised that understanding how this binding takes place could contribute to the creation of drugs that target these receptors.

Targeting this receptor could yield the greatest therapeutic effect in heavy drinkers, while reducing topiramate's common side effects, which commonly include fatigue, dizziness, and memory problems.

In fact, large human liver cancer tumors on comparatively small mice started regressing about 20 days after treatment, and were eradicated by day 41 with the help of one of the targeted receptors.

These observations demonstrate that the D - Tyr - Arg peptide bond is crucial for the peptide conformation and thus for an optimized interaction with the targeted receptor.

One of the viral genes, env, specifies a protein that forms the viral envelope, the outer covering of the virus that interacts with a target receptor on the surface of lung cells.

Direct — this occurs when growth hormone binds to its targeted receptor cells to create an action or effect

Specifically, it targets receptors in the body to increase muscle mass and bone density.

«Establishing an animal model is paramount for testing new treatment and prevention modalities, especially for lesions that express none of the targeted receptors, such as triple - negative types, before human clinical trials,» Mohammed said.