Another surprise is that the nematode genes identified so far are packed much more tightly
together on the chromosome than anyone had previously expected, which suggests that the nematode has many more genes in total than was previously thought.
Genes that are grouped
together on chromosomes in other animals were dispersed in the octopus genome, likely as a result of transposon activity.
Not exact matches
First a
chromosome is catastrophically shattered when it loses the caps
on its ends, known as telomeres, that hold it
together.
So team member Jaebum Kim, now at Konkuk University in Seoul, and colleagues wrote a sophisticated computer program that was able to reconstruct the original eutherian
chromosomes based
on what parts of the
chromosomes are
together today in those 19 species.
After analyzing both scans
together for DNA variants associated with differences between when each patient's movement - associated symptoms first appeared and when they would have been expected based
on the number of CAG repeats, MGH CHGR investigator and lead author Jong - Min Lee, PhD, identified two locations
on chromosome 15 where variants were significantly associated with either early or late symptom onset.
However, some genes are close enough
together on the same
chromosome that they frequently do get passed along
together.
As when he worked
on the human genome, Venter is relying
on a radical technique called shotgun sequencing: He chops up vast amounts of DNA into tiny pieces and then uses sophisticated computer analyzers to piece them back
together into intelligible genes and
chromosomes.
Jim (
on the right), whose Y
chromosome was sequenced,
together with Dolly, his mother, and Binti, his sister.
Biologists and informatics experts are launching a quiet revolution aimed at building better genomes, one made possible by newer sequencing technologies, novel methods for locating sequences
on chromosomes, and improved software for piecing DNA
together.
Genes which lie close to one another
on a
chromosome are usually inherited
together and are said to be linked.
The team focused
on the six best - assembled genomes to put
together a karyotype — organised profile — of the dinosaur ancestor for each
chromosome.
Telomeres are important because they stop
chromosomes from «fraying» or clumping
together and «scrambling» the genetic codes they contain, performing a role similar to the plastic tips
on the end of shoelaces, to which they have been likened.
This inversion prevented genes within it from recombining with corresponding genes
on a sister
chromosome, and so cemented around 125 adjacent genes
together.
Because genes and plant regulatory networks are distinct from one another, closely coordinated genes can be widely separated from one another
on chromosomes and still work
together effectively and in many crop plants (maize for instance) much of the DNA does not contain genes.
They will focus
on how those genes, from different parts of
chromosomes, work
together to determine what type of heart cells will be made, and how these mechanisms are disrupted by gene mutations that cause congenital heart defects.
The authors exploited linkage disequilibrium (the tendency of variants
on the same
chromosome to be inherited
together) to identify, in Europeans, variants that tend to be inherited
together with associated SNPs.
In his lab at UCSD now, Corbett focuses
on the proteins that organize meiotic
chromosomes and control meiotic recombination, the cutting and pasting
together of
chromosomes.
Segments of DNA that are located
on the same
chromosome are «linked» because they are likely to be inherited
together, with the segments in closest proximity being the most likely.