Sentences with word «tomatidine»

According to the team lead by Dr. Adams, apple peels contain ursolic acid, while the skin of green tomatoes contain tomatidine compounds.

It was found that healthy mice who consumed tomatidine experienced greater muscle growth, muscle strength and developed greater endurance when they were put under strenuous physical activity.

Adams» team investigated the molecular effects of ursolic acid and tomatidine in aged skeletal muscle.

After discovering tomatidine's properties, it was tested on skeletal muscle to see its effects.

But it is still unknown how many green tomatoes one needs to eat to get the same tomatidine dose that was given to mice.

Another very attractive property of tomatidine is that it is naturally found in tomatoes.

A team of researchers that had previously found a substance in apple peel which works as a muscle - building agent has recently also discovered that another substance called tomatidine, found in green tomatoes can be even more powerful when it comes to building muscle and preventing muscle wasting, otherwise known as muscle atrophy.

It was found that tomatidine makes changes in the way genes are expressed that are the exact opposite to those changes that are happening in the muscle cells in people who suffer from muscle wasting.

«We also thought we might be able to use ursolic acid and tomatidine as tools to find a root cause of muscle weakness and atrophy during aging.»

«By reducing ATF4 activity, ursolic acid and tomatidine allow skeletal muscle to recover from effects of aging,» says Adams, who also is a member of the Fraternal Order of Eagles Diabetes Research Center and the Pappajohn Biomedical Institute, and is a staff physician with the Iowa City Veterans Affairs Medical Center.

Elderly mice with age - related muscle weakness and atrophy were fed diets lacking or containing either 0.27 percent ursolic acid, or 0.05 percent tomatidine for two months.

The UI study was done in collaboration with Emmyon, Inc., a UI - based biotechnology company founded by Adams, that is now working to translate ursolic acid and tomatidine into foods, supplements, and pharmaceuticals that can help preserve or recover strength and muscle mass as people grow older.

«Based on these results, ursolic acid and tomatidine appear to have a lot of potential as tools for dealing with muscle weakness and atrophy during aging,» Adams says.

The promising results of the study, the research into the effectiveness of ursolic acid and tomatidine compounds is to continue with human trials, ultimately resulting into new supplements for prolonging muscle growth.

In their latest study, Adams» team found that ursolic acid and tomatidine dramatically reduce age - related muscle weakness and atrophy in mice.

The mice were subjected to a two month diet with high concentration of ursolic acid and / or tomatidine.

And what's even more astounding, even though the mice who consumed tomatidine had bigger muscles, the average body weight didn't change because they lost a big amount of fat, which suggests that tomatidine can also have obesity treating properties.

It is widely believed in the scientific community that several natural substances found in common foods, like ursolic acid and tomatidine may, in the near future, be put together in food supplements or incorporated into people's diets to improve their general health.

Primarily via stimulating protein synthesis, although some researchers are even looking for ways to activate it to prevent atrophy (eg, Dyle et al., 2014)(eg, ursolic acid & tomatidine).

Like old muscles that were treated with ursolic acid and tomatidine, old muscles lacking ATF4 were resistant to the effects of aging.

Previously, Adams and his team had identified ursolic acid, which is found in apple peel, and tomatidine, which comes from green tomatoes, as small molecules that can prevent acute muscle wasting caused by starvation and inactivity.

Those studies set the stage for testing whether ursolic acid and tomatidine might be effective in blocking the largest cause of muscle weakness and atrophy: aging.

It's also high in tomatidine, which has been shown to boost muscle mass in mice by reducing the activity of a gene called ATF4, known for inhibiting muscle protein synthesis.