With most of the same genes as humans, but far easier to manipulate and study, mice are essential
tools for studying disease.
These cells could then be used as
a tool for studying these diseases and screening potential drug compounds, says Suzuki.
Stricter safety procedures and new ways to weaken pathogens to reduce their risks are leading investigators in industry, universities, and government to take a new look at human challenge trials, which offer a powerful
tool for studying diseases and potential therapies.
Not exact matches
Because, as Belmonte rightly explains, the new «precisely targeted»
tools can help us «
study species evolution, biology and
disease, and may lead ultimately to the ability to grow human organs
for transplant.»
The
study concludes that comprehensive screening
for canine inherited disorders represents an efficient and powerful diagnostic and research discovery
tool that has a range of applications in veterinary care,
disease research, and dog breeding.
Biomarkers signatures, detected with panels of high - quality antibodies, are another powerful
tool for studying neurological
diseases and conditions.
The
study of viruses far removed from human concerns has brought to light powerful
tools for the
study of human
disease.
As
for the Lund researchers, the method provides a
tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological
diseases.
Preliminary results of the
study were presented at a World Health Organization (WHO) evidence review group meeting, while UNITAID has issued a call
for further research into the use of endectocide class drugs, of which ivermectin is currently the only one registered
for human use, as new vector control
tools in the fight against malaria and other mosquito borne
disease.
The Immunochip
for fine - mapping is an important
tool for conducting genome - wide association
studies of the genetic components of
disease.
«This approach, termed DiceCT, can be widely applied, not just
for evolutionary
studies but also as a powerful
tool for biomedical investigations of brain development in
disease, congenital defects, or injury,» she said.
The
study also examines the use of lentiviral vectors
for cell delivery in treating liver
diseases, a
tool traditionally used in treating blood disorders.
«Reprogramming patients» cells offers powerful new
tool for studying, treating blood
diseases.»
«This
study allowed us to utilize all our
tools — and even though this virus does not appear to affect mammals, we are continuing to refine those
tools so we can be better prepared
for the next outbreak of
disease that could have an impact on human health.»
The
study paves the way
for CRISPR - Cas9 as a powerful gene editing
tool with potential therapeutic applications
for inherited
diseases — leading to more widely available gene therapy techniques.
«Finches offer researchers a new
tool with which to
study Huntington's
disease: Like humans, songbirds learn their vocalizations, suggesting they could be useful as models
for certain disorders.»
Small - animal imaging has become an important research
tool for preclinical
studies of infectious
diseases, according to senior author Thomas M. Bocan, Ph.D., of the U.S. Army Medical Research Institute of Infectious
Diseases (USAMRIID).
But the
study, conducted through the new USTAR Center
for Genetic Discovery at the U of U, shows that Phevor's unique approach allows it to identify
disease - causing genes more precisely than other computational
tools.
For now, they don't have a clue about the virus's origins or why it's suddenly causing an outbreak; in order to speed up the process, they want to share the virus and protocols for detecting it with anyone interested in studying the disease or developing diagnostic tools and vaccin
For now, they don't have a clue about the virus's origins or why it's suddenly causing an outbreak; in order to speed up the process, they want to share the virus and protocols
for detecting it with anyone interested in studying the disease or developing diagnostic tools and vaccin
for detecting it with anyone interested in
studying the
disease or developing diagnostic
tools and vaccines.
It also is an ability that is consistently impaired in patients with Parkinson's
disease (PD), and
for University of Iowa neurologist Nandakumar Narayanan that makes «timing» an ideal
tool to
study cognitive problems in PD.
When epidemiological data are scarce, social media and Internet reports can be reliable
tools for forecasting infectious
disease outbreaks, according to a
study led by an expert in the School of Public Health at Georgia State University.
In theory, the
disease could be halted by limiting people's access to unaffected areas, but that would be a very unpopular policy and perhaps impossible to implement, he says.The rapid spread of sudden oak death is «such a dynamic system that a lot of our
tools in ecology
for understanding and predicting patterns are inadequate,» says Rick Ostfeld of the Institute of Ecosystem
Studies in Millbrook, New York.
A recent
study led by Alice Lam, MD, PhD, also of the MGH Epilepsy Service and lead author of the current
study demonstrated a novel
tool for detecting hippocampal seizures not detectible by scalp EEGs in patients with epilepsy, Cole adds, and his team is working to refine this
tool and apply it to Alzheimer's
disease.
«Additional recordings with FO electrodes in patients with Alzheimer's
disease will help us develop better
tools based on computerized analysis of EEG signals and possibly functional neuroimaging
studies to ascertain how common silent seizures are in Alzheimer's
disease without the need
for the minimally invasive electrodes we used in these patients.»
Scientists
for years have looked
for the biological roots of the problem using
tools such as genome - wide association
studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint
disease - causing genetic variants.
In 2009, he established the Center
for Human
Disease Modeling at Duke University, which aims to facilitate collaboration across disciplines and to develop physiologically relevant, scalable
tools to
study variation among human patient genomes.
the generation of novel mouse models of Cystic Fibrosis by exploring genetically - diverse murine populations that will provide unique
tools for disease modeling and pre-clinical
studies.
Since SCID mice have no natural immunity and can not reject tissue transplants, they have become valuable research
tools for studying many
diseases, including cancer and HIV.
Scientists from the UNC School of Medicine have developed a new
tool for studying a key process in cells called G - protein signaling, which plays a central role in the normal functioning of cells and can go awry to cause severe
disease, including cancers.
Not so long ago, the advent of powerful genomic
tools and genetic engineering techniques made it seem that
studies involving mice engineered to carry human
disease genes would be the best approach
for exploring human disorders, superior to looking at cells isolated in a laboratory.
NIMML researchers employ advanced computational
tools in combination with experimental and clinical
studies to capture variation and diversity of immune responses, and develop safer, more - effective precision medicine treatments
for infectious and immune - mediated
diseases.
«Our method promises to be a powerful
tool for studying the mechanisms of human
diseases and developing new therapies,» they wrote in the journal Nature.
Genetically modified goats are an important
tool for producing valuable therapeutic protein [14]--[16] and
studying human
diseases as ideal biomedical models [17]--[19].
Genome sequencing has become a powerful
tool for studying emerging infectious
diseases; however, genome sequencing directly from clinical samples without isolation remains challenging
for viruses such as Zika, where metagenomic sequencing methods may generate insufficient numbers of viral reads.
This resource constitutes an important infrastructure and
tool for the
study of complex genetic traits, the positional cloning of
disease genes, the cross-referencing of mammalian genomes, and validated human transcribed sequences
for large - scale
studies of gene expression.
Humanized NSG ™ and NSG ™ - SGM3 mouse models are powerful
tools for studying cancer, inflammatory and infectious
disease, and hematopoiesis.
In addition to providing a much - needed diagnostic
tool, this technique will provide a way to monitor lesions
for future
studies assessing new drug therapies
for dogs with this devastating
disease.